P. Nelson

Works (1)

Updated: July 20th, 2023 21:16

1995 journal article

Therapeutic effects of diethylcarbamazine and 3′-azido-3′-deoxythymidine on feline leukemia virus lymphoma formation

Veterinary Immunology and Immunopathology, 46(1-2), 181–194.

By: P. Nelson n, R. Sellon n, C. Novotney n, C. Devera n, M. Davidian n , R. English n, M. Tompkins n, W. Tompkins n

MeSH headings : Animals; Antibodies, Viral / blood; Cat Diseases / drug therapy; Cat Diseases / immunology; Cats; Diethylcarbamazine / administration & dosage; Diethylcarbamazine / therapeutic use; Enzyme-Linked Immunosorbent Assay / veterinary; Flow Cytometry / veterinary; Gene Products, gag / immunology; Leukemia Virus, Feline / drug effects; Leukemia Virus, Feline / immunology; Leukocyte Count / veterinary; Leukopenia / drug therapy; Leukopenia / immunology; Lymphocytes / immunology; Lymphoma / drug therapy; Lymphoma / immunology; Lymphoma / veterinary; Random Allocation; Retroviridae Infections / drug therapy; Retroviridae Infections / immunology; Retroviridae Infections / veterinary; Retroviridae Proteins, Oncogenic / immunology; Specific Pathogen-Free Organisms; Survival Rate; Tumor Virus Infections / drug therapy; Tumor Virus Infections / immunology; Tumor Virus Infections / veterinary; Viral Envelope Proteins / immunology; Zidovudine / administration & dosage; Zidovudine / therapeutic use
TL;DR: DEC as well as AZT therapy delays the development of lymphomas associated with FeLV infection and significantly improves survival, suggesting FeLVR-induced immunosuppression. (via Semantic Scholar)
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Added: August 6, 2018

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