@article{silver_dauterman_1989, title={THE TOXICOKINETICS OF (1R, CIS)-TETRAMETHRIN AND (1R, TRANS)-TETRAMETHRIN IN THE ISOLATED PERFUSED RAT-LIVER}, volume={19}, ISSN={["0049-8254"]}, DOI={10.3109/00498258909042290}, abstractNote={1. The toxicokinetics of cis- and trans-tetramethrin isomers were investigated using the isolated perfused rat liver preparation. 2. The concentration of cis- and trans-tetramethrin decreased rapidly in the plasma perfusate and was initially replaced by N-(hydroxymethyl)3,4,5,6-tetrahydrophthalimide (MTI) and then by 3,4,5,6-tetrahydrophthalimide (TPI). Plasma perfusate concentrations of the intact cis-isomer were higher than those of the trans-isomer. Concentrations of MTI and TPI were higher in livers treated with the trans-isomer. 3. Tetramethrin and its metabolites were rapidly excreted in the bile. Bile from livers perfused with trans-isomer contained higher concentrations of parent isomer and metabolites MTI and TPI, than did bile from livers treated with the cis-isomer.}, number={5}, journal={XENOBIOTICA}, author={SILVER, IS and DAUTERMAN, WC}, year={1989}, month={May}, pages={509–519} }