Krystyna L. Tyczkowska

Works (14)

Updated: February 10th, 2025 14:29

1999 journal article

Phase I and pharmacokinetic analysis of high-dose tamoxifen and chemotherapy in normal and tumor-bearing dogs

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 44(1), 74–80.

By: . Waddle n, R. Fine*, B. Case n, M. Trogdon n, K. Tyczkowska n, D. Frazier*, R. Page n

author keywords: P-glycoprotein 170; multidrug resistance; tamoxifen; doxorubicin; canine
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis; ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects; Animals; Antineoplastic Agents, Hormonal / administration & dosage; Antineoplastic Agents, Hormonal / adverse effects; Antineoplastic Agents, Hormonal / pharmacokinetics; Digestive System / drug effects; Dogs; Dose-Response Relationship, Drug; Doxorubicin / adverse effects; Doxorubicin / pharmacokinetics; Drug Interactions; Drug Resistance, Multiple; Female; Male; Neoplasms, Experimental / metabolism; Tamoxifen / administration & dosage; Tamoxifen / adverse effects; Tamoxifen / pharmacokinetics; Tissue Distribution
TL;DR: Concentrations of tamoxifen/NDMT sufficient to inhibit Pgp may be achieved in dogs receiving full-dose chemotherapy with a moderate but acceptable increase in gastrointestinal toxicity. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Pharmacokinetic parameters and milk concentrations of ketoprofen after administration as a single intravenous bolus dose to lactating goats

Journal of Veterinary Pharmacology and Therapeutics, 21(5), 358–363.

By: J. Musser n, K. Anderson n & K. Tyczkowska n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Female; Goats / physiology; Injections, Intravenous; Ketoprofen / administration & dosage; Ketoprofen / pharmacokinetics; Lactation; Milk / chemistry; Milk / metabolism
TL;DR: Six clinically normal lactating does were administered ketoprofen intravenously and the drug was unmeasurable by the method employed (level of detection 25 ng/mL) for all samples. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Quantitative determination of ceftiofur in milk by liquid chromatography electrospray mass spectrometry

JOURNAL OF CHROMATOGRAPHY A, 794(1-2), 57–62.

By: J. Keever*, R. Voyksner * & K. Tyczkowska n

author keywords: mass spectrometry; ceftiofur
MeSH headings : Animals; Cephalosporins / analysis; Chromatography, Liquid; Food Contamination / analysis; Indicators and Reagents; Mass Spectrometry; Milk / chemistry; Solvents
TL;DR: A liquid chromatography-electrospray mass spectrometry (LC-ES-MS) was developed for the quantitation of ceftiofur in milk at the 50 ppb tolerance level set by the US Food and Drug Administration for the drug. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1994 journal article

Simultaneous determination of enrofloxacin and its primary metabolite ciprofloxacin in bovine milk and plasma by ion-pairing liquid chromatography

Journal of Chromatography B: Biomedical Sciences and Applications, 658(2), 341–348.

By: K. Tyczkowska n, R. Voyksner *, K. Anderson  n & M. Papich n 

MeSH headings : Animals; Anti-Infective Agents / analysis; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Biotransformation; Cattle; Chromatography, Ion Exchange; Ciprofloxacin / analysis; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones; Injections, Intravenous; Milk / chemistry; Quinolones / analysis; Quinolones / blood; Quinolones / pharmacokinetics; Spectrophotometry, Ultraviolet; Ultrafiltration
TL;DR: A simple and sensitive high-performance liquid chromatographic method has been developed for the simultaneous determination of enrofloxacin and ciprofl oxacin in bovine milk and plasma. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

1994 journal article

Simultaneous multiresidue analysis of beta-lactam antibiotics in bovine milk by liquid chromatography with ultraviolet detection and confirmation by electrospray mass spectrometry

Journal of AOAC International, 77(5), 1122.

By: K. Tyczkowska, R. Voyksner, R. Straub & A. Aronson

Source: NC State University Libraries
Added: August 6, 2018

1993 journal article

DETERMINATION OF CEFTIOFUR AND ITS METABOLITE DESFUROYLCEFTIOFUR IN BOVINE SERUM AND MILK BY ION-PAIRED LIQUID-CHROMATOGRAPHY

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 614(1), 123–134.

By: K. Tyczkowska n, R. Voyksner *, K. Anderson  n & A. Aronson n

MeSH headings : Animals; Cattle; Cephalosporins / analysis; Cephalosporins / blood; Cephalosporins / metabolism; Chromatography, Liquid / methods; Female; Ions; Mass Spectrometry; Milk / chemistry; Reproducibility of Results; Spectrophotometry, Ultraviolet
TL;DR: The presence of a ceftiofur metabolite in bovine serum under in vitro and in vivo conditions is documents and the limit of detection was estimated to be approximately 50 ppb (ng/ml). (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1991 journal article

DEVELOPMENT OF AN ANALYTICAL METHOD FOR CEPHAPIRIN AND ITS METABOLITE IN BOVINE-MILK AND SERUM BY LIQUID-CHROMATOGRAPHY WITH UV-VIS DETECTION AND CONFIRMATION BY THERMOSPRAY MASS-SPECTROMETRY

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 14(1), 51–60.

By: K. Tyczkowska n, R. Voyksner * & A. Aronson n

MeSH headings : Animals; Cattle; Cephapirin / analysis; Cephapirin / blood; Chromatography, Liquid / methods; Chromatography, Liquid / veterinary; Female; Gas Chromatography-Mass Spectrometry / methods; Gas Chromatography-Mass Spectrometry / veterinary; Milk / chemistry
TL;DR: The principal metabolite was tentatively identified as desacetylcephapirin by liquid chromatography with UV-VIS photodiode array (LC/UV-VIS PDA), and liquid-chromatography-mass-spectrometric (LC-MS) detection. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1990 article

DETERMINATION OF CARBOPLATIN IN CANINE PLASMA BY LIQUID-CHROMATOGRAPHY WITH ULTRAVIOLET VISIBLE DETECTION AND CONFIRMATION BY ATOMIC-ABSORPTION SPECTROSCOPY

TYCZKOWSKA, K., PAGE, R. L., & RIVIERE, J. E. (1990, May 18). JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, Vol. 527, pp. 447–453.

By: K. Tyczkowska n, R. Page n & J. Riviere n

MeSH headings : Animals; Antineoplastic Agents / blood; Carboplatin; Chromatography, High Pressure Liquid / methods; Dogs; Molecular Structure; Organoplatinum Compounds / blood; Protein Binding; Spectrophotometry, Atomic
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1989 journal article

DETERMINATION OF DOXYCYCLINE IN BOVINE-TISSUES AND BODY-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING PHOTODIODE ARRAY ULTRAVIOLET-VISIBLE DETECTION

JOURNAL OF PHARMACEUTICAL SCIENCES, 78(1), 44–47.

By: J. Riond n, K. Hedeen n, K. Tyczkowska n & J. Riviere n

MeSH headings : Animals; Cattle; Chromatography, High Pressure Liquid; Doxycycline / analysis; Doxycycline / blood; Doxycycline / urine; Indicators and Reagents; Kidney Medulla / analysis; Liver / analysis; Muscles / analysis; Spectrophotometry, Ultraviolet
TL;DR: A sensitive and selective high-performance liquid chromatographic assay was developed to quantitate doxycycline concentrations in bovine tissues and body fluids to extract tissue-bound drug. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1989 journal article

Development of an analytical method for penicillin G in bovine milk by liquid chromatography with ultraviolet-visible detection and confirmation by mass spectrometric detection

Journal of Chromatography. A, 490(1), 101.

By: K. Tyczkowska, R. Voyksner & A. Aronson

Source: NC State University Libraries
Added: August 6, 2018

1989 journal article

HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS DETERMINATION OF ENROFLOXACIN AND ITS PRIMARY METABOLITE CIPROFLOXACIN IN CANINE SERUM AND PROSTATIC TISSUE

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 493(2), 337–346.

By: K. Tyczkowska n, K. Hedeen n, D. Aucoin  n & A. Aronson n

MeSH headings : Animals; Anti-Infective Agents / blood; Anti-Infective Agents / metabolism; Chromatography, High Pressure Liquid; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Dogs; Enrofloxacin; Fluoroquinolones; Male; Prostate / analysis; Quinolones; Spectrophotometry, Ultraviolet
TL;DR: A simple and sensitive high-performance liquid chromatographic method was developed for the determination of enrofloxacin and ciprofloxin in canine serum and prostatic tissue and the limits of detection were 4 and 2 ng/ml, respectively. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1989 journal article

Pharmacokinetics and metabolic inertness of doxycycline in calves with mature or immature rumen function

American Journal of Veterinary Research, 50, 1329–1333.

By: J. Riond, K. Tyczkowska & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

1987 journal article

THE DETERMINATION OF PLATINUM IN BIOLOGICAL-MATERIALS BY ELECTROTHERMAL ATOMIC-ABSORPTION SPECTROSCOPY

SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, 42(5), 665–668.

By: M. Mcgahan  n & K. Tyczkowska n

TL;DR: The wet ashing technique is fast and convenient and requires minimal sample treatment, and there was complete recovery of platinum added to the tissues when the tissues were wet ashed. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1986 journal article

Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs

International Journal of Hyperthermia, 2, 351–358.

By: J. Riviere n, R. Page n, M. Dewhirst*, K. Tyczkowska n & D. Thrall n

MeSH headings : Animals; Biotransformation; Cisplatin / blood; Cisplatin / metabolism; Dogs; Half-Life; Hyperthermia, Induced / methods; Kinetics; Platinum / blood; Spectrophotometry, Atomic; Ultrafiltration
TL;DR: Data from in vitro and in vivo cisplatin pharmacokinetic studies in dogs would indicate that at the elevated temperatures encountered in whole body hyperthermia, the rate of formation of reactive metabolites from parent cisPlatin is increased. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2025) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.