Pharmacokinetics of carbetocin, a long-acting oxytocin analogue, following intravenous administration in horses
EQUINE VETERINARY JOURNAL, 40(7), 658–661.
author keywords: horse; oxytocin; pharmacokinetics; carbetocin
MeSH headings : Animals; Area Under Curve; Female; Half-Life; Heart Rate / drug effects; Horse Diseases / blood; Horse Diseases / drug therapy; Horses / blood; Injections, Intravenous / veterinary; Oxytocin / adverse effects; Oxytocin / analogs & derivatives; Oxytocin / pharmacokinetics; Oxytocin / therapeutic use; Pain / chemically induced; Pain / epidemiology; Pain / veterinary; Radioimmunoassay / veterinary; Respiration / drug effects
TL;DR:
The half-life of carbetocin is greater than that previously reported for oxytocin (6.8 min) and is an attractive alternative to Oxytocin therapy in broodmare management.
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