Nicholas J. H. Sharp

Works (35)

Updated: March 10th, 2025 12:14

2005 article

Stringhalt associated with a pasture infested with Hypochoeris radicata

Gardner, S. Y., Cook, A. G., Jortner, B. S., Troan, B. V., Sharp, N. J. H., Campbell, N. B., & Brownie, C. F. (2005, June 1). Equine Veterinary Education.

By: S. Gardner n, A. Cook*, B. Jortner *, B. Troan  n, N. Sharp n, N. Campbell n, C. Brownie n

topics (OpenAlex): Plant and fungal interactions; Helminth infection and control; Diphtheria, Corynebacterium, and Tetanus
Source: NC State University Libraries
Added: August 6, 2018

2004 article

Recovery of Pelvic Limb Function in Dogs following Acute Intervertebral Disc Herniations

Olby, N., Harris, T., Burr, J., Muñana, K., Sharp, N., & Keene, B. (2004, January 1). Journal of Neurotrauma, Vol. 21, pp. 49–59.

By: N. Olby n , T. Harris n, J. Burr n, K. Muñana n , N. Sharp n & B. Keene n

Contributors: N. Olby n , T. Harris n, J. Burr n, K. Muñana n , N. Sharp n & B. Keene n

author keywords: dog; disc herniation; functional recovery; spinal cord compression; spinal cord trauma
MeSH headings : Animals; Disease Models, Animal; Dogs; Hindlimb / physiopathology; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / physiopathology; Lumbosacral Region / physiopathology; Pelvis / pathology; Recovery of Function; Spinal Cord Injuries / etiology; Spinal Cord Injuries / physiopathology; Thoracic Vertebrae / physiopathology
topics (OpenAlex): Veterinary Orthopedics and Neurology; Spinal Cord Injury Research; Spine and Intervertebral Disc Pathology
TL;DR: It is concluded that dogs with spontaneous disc herniations provide a useful model of acute spinal cord injury for clinical trials and are suitable for use in clinical trials on neuroprotective drugs. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 article

A model of mucopolysaccharidosis IIIB (Sanfilippo syndrome type IIIB): N‐acetyl‐α‐D‐glucosaminidase deficiency in Schipperke dogs

Ellinwood, N. M., Wang, P., Skeen, T., Sharp, N. J. H., Cesta, M., Decker, S., … Giger, U. (2003, July 1). Journal of Inherited Metabolic Disease.

By: N. Ellinwood *, P. Wang*, T. Skeen n, N. Sharp*, M. Cesta n, S. Decker n, N. Edwards *, I. Bublot n ...

MeSH headings : Acetylglucosaminidase / deficiency; Animals; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Female; Glycosaminoglycans / urine; Male; Mucopolysaccharidosis III / genetics; Mucopolysaccharidosis III / metabolism; Mucopolysaccharidosis III / pathology
topics (OpenAlex): Lysosomal Storage Disorders Research; Glycogen Storage Diseases and Myoclonus; Trypanosoma species research and implications
TL;DR: Dogs with naturally occurring MPS IIIB are reported on, detailing the clinical signs, diagnosis, histopathology, tissue enzymology and substrate levels, and an obligate heterozygote has been established to aid in understanding the pathogenesis of MPSIIIB and testing of potential therapies. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

Long-term functional outcome of dogs with severe injuries of the thoracolumbar spinal cord: 87 cases (1996–2001)

Journal of the American Veterinary Medical Association, 222(6), 762–769.

By: N. Olby n , J. Levine n , T. Harris*, K. Muñana n , T. Skeen n & N. Sharp n

Contributors: N. Olby n , J. Levine n , T. Harris*, K. Muñana n , T. Skeen n & N. Sharp n

MeSH headings : Age Factors; Animals; Body Weight; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Displacement / physiopathology; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Laminectomy / veterinary; Lumbar Vertebrae; Male; Pain / veterinary; Paraplegia / etiology; Paraplegia / surgery; Paraplegia / veterinary; Prognosis; Recovery of Function; Retrospective Studies; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Thoracic Vertebrae; Treatment Outcome
topics (OpenAlex): Veterinary Orthopedics and Neurology; Spinal Cord Injury Research; Nerve Injury and Rehabilitation
TL;DR: Results suggested that the prognosis for paraplegic dogs without DPP because of trauma was guarded, while dogs with disk herniation had a better chance of recovering motor function. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2003 journal article

Molecular genetic and expression analysis of alpha-tocopherol transfer protein mRNA in German shepherd dogs with degenerative myelopathy

Berliner Und Munchener Tierarztliche Wochenschrift (Berlin, Germany : 1949), 116(1-2), 31–36.

By: H. Fechner, P. Johnston, N. Sharp, P. Montague, I. Griffiths, X. Wang, N. Olby , A. Looman, W. Poller, T. Flegel

Source: NC State University Libraries
Added: August 6, 2018

2003 article

RELATIONSHIP AMONG BASILAR ARTERY RESISTANCE INDEX, DEGREE OF VENTRICULOMEGALY, AND CLINICAL SIGNS IN HYDROCEPHALIC DOGS

Saito, M., Olby, N. J., Spaulding, K., Mun̄ana Karen, & Sharp, N. J. H. (2003, November 1). Veterinary Radiology & Ultrasound, Vol. 44, pp. 687–694.

By: M. Saito n, N. Olby n , K. Spaulding n, K. Mun̄ana n  & N. Sharp n

Contributors: M. Saito n, N. Olby n , K. Spaulding n, K. Muñana n  & N. Sharp n

author keywords: hydrocephalus; resistance index; ventriculomegaly; ultrasound
MeSH headings : Animals; Basilar Artery / physiopathology; Blood Flow Velocity / veterinary; Cerebrovascular Circulation; Dog Diseases / diagnostic imaging; Dog Diseases / physiopathology; Dogs; Female; Hydrocephalus / physiopathology; Hydrocephalus / veterinary; Male; Predictive Value of Tests; Pulsatile Flow; Sensitivity and Specificity; Severity of Illness Index; Ultrasonography, Doppler, Transcranial / methods; Vascular Resistance
topics (OpenAlex): Cerebrospinal fluid and hydrocephalus; Traumatic Brain Injury and Neurovascular Disturbances; Fetal and Pediatric Neurological Disorders
TL;DR: The results suggest that ultrasonographic measurement of VB ratio and basilar artery RI may allow identification of dogs with symptomatic hydrocephalus or dogs that are at risk of developing symptomatic Hydrocephalus. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 article

Spinal Arachnoid Cysts in 17 Dogs

Skeen, T. M., Olby, N. J., Muñana Karen R., & Sharp, N. J. (2003, May 1). Journal of the American Animal Hospital Association, Vol. 39, pp. 271–282.

By: T. Skeen n, N. Olby n , K. Muñana n  & N. Sharp n

Contributors: T. Skeen n, N. Olby n , K. Muñana n  & N. Sharp n

MeSH headings : Animals; Arachnoid Cysts / epidemiology; Arachnoid Cysts / veterinary; Cervical Vertebrae; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / etiology; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Female; Magnetic Resonance Imaging / veterinary; Male; Myelography / veterinary; North Carolina / epidemiology; Records / veterinary; Retrospective Studies; Spinal Diseases / epidemiology; Spinal Diseases / veterinary; Spinal Fusion / veterinary; Thoracic Vertebrae
topics (OpenAlex): Spinal Dysraphism and Malformations; Veterinary Orthopedics and Neurology; Cerebrospinal fluid and hydrocephalus
TL;DR: The medical records of 17 dogs diagnosed with spinal arachnoid cysts at North Carolina State University Veterinary Teaching Hospital were retrospectively examined to identify trends in signalment, history, neurological status, treatment, and short- and long-term prognosis. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2003 article

Use of a multiplex polymerase chain reaction assay in the antemortem diagnosis of toxoplasmosis and neosporosis in the central nervous system of cats and dogs

Schatzberg, S. J., Haley, N. J., Barr, S. C., deLahunta, A., Olby, N., Munana, K., & Sharp, N. J. H. (2003, December 1). American Journal of Veterinary Research, Vol. 64, pp. 1507–1513.

By: S. Schatzberg, N. Haley  n, S. Barr n, A. deLahunta n, N. Olby n , K. Munana n , N. Sharp n

Contributors: S. Schatzberg, N. Haley  n, S. Barr n, A. deLahunta n, N. Olby n , K. Munana n , N. Sharp n

MeSH headings : Animals; Cats; Central Nervous System / parasitology; Coccidiosis / diagnosis; Coccidiosis / veterinary; DNA Primers; Dogs; Electrophoresis, Agar Gel; Neospora / genetics; Polymerase Chain Reaction / methods; Sequence Analysis, DNA; Toxoplasma / genetics; Toxoplasmosis, Animal / diagnosis
topics (OpenAlex): Toxoplasma gondii Research Studies; Rabies epidemiology and control; Herpesvirus Infections and Treatments
TL;DR: The multiplex PCR assay with built-in control reactions could be a complementary clinical tool for the antemortem diagnosis of toxoplasmosis or neosporosis associated with the CNS. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2002 article

CT FINDINGS OF INTRACRANIAL BLASTOMYCOSIS IN A DOG

Saito, M., Sharp, N. J. H., Munana, K., Troan, B. V., Tokuriki, M., & Thrall, D. E. (2002, January 1). Veterinary Radiology & Ultrasound, Vol. 43, pp. 16–21.

By: M. Saito*, N. Sharp*, K. Munana* , B. Troan *, M. Tokuriki n & D. Thrall n

Contributors: M. Saito*, N. Sharp*, K. Munana* , B. Troan *, M. Tokuriki n & D. Thrall n

MeSH headings : Animals; Blastomycosis / diagnostic imaging; Blastomycosis / pathology; Blastomycosis / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Male; Tomography, X-Ray Computed
topics (OpenAlex): Veterinary Oncology Research; Glycosylation and Glycoproteins Research; Milk Quality and Mastitis in Dairy Cows
TL;DR: Computed tomography findings in a dog with intracranial blastomycosis were marked periventricular contrast enhancement of the lateral ventricles, the 3rd ventricle, and the mesencephalic aqueduct. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2002 article

Dorsal Laminectomy for Caudal Cervical Spondylomyelopathy: Postoperative Recovery and Long‐Term follow‐up in 20 Dogs

Risio, L. D., Muñana, K., Murray, M., Olby, N., Sharp, N. J. H., & Cuddon, P. (2002, September 1). Veterinary Surgery, Vol. 31, pp. 418–427.

By: L. Risio  n, K. Muñana n , M. Murray n, N. Olby n , N. Sharp n & P. Cuddon n

Contributors: L. De Risio  n, K. Muñana n , M. Murray n, N. Olby n , N. Sharp n & P. Cuddon n

MeSH headings : Animals; Cervical Vertebrae / surgery; Colorado / epidemiology; Dog Diseases / mortality; Dog Diseases / surgery; Dogs; Female; Follow-Up Studies; Laminectomy / veterinary; Male; Neurologic Examination / veterinary; North Carolina / epidemiology; Postoperative Complications / veterinary; Records / veterinary; Recurrence; Retrospective Studies; Spinal Osteophytosis / mortality; Spinal Osteophytosis / surgery; Spinal Osteophytosis / veterinary; Treatment Outcome
topics (OpenAlex): Veterinary Orthopedics and Neurology; Cervical and Thoracic Myelopathy; Spine and Intervertebral Disc Pathology
TL;DR: Dorsal cervical laminectomy is an effective treatment for CCSM in those dogs with dorsal compression or multiple sites of involvement and long-term outcome and recurrence rates were comparable to those seen with other surgical techniques for C CSM. (via Semantic Scholar)
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Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2002 article

MAGNETIC RESONANCE IMAGING FEATURES OF LISSENCEPHALY IN 2 LHASA APSOS

Saito, M., Sharp, N. J. H., Kortz, G. D., Lahunta, A. D., Leventer, R. J., Tokuriki, M., & Thrall, D. E. (2002, July 1). Veterinary Radiology & Ultrasound.

By: M. Saito n, N. Sharp n, G. Kortz*, A. Lahunta*, R. Leventer *, M. Tokuriki*, D. Thrall n

MeSH headings : Animals; Brain / abnormalities; Brain / pathology; Breeding; Diagnosis, Differential; Dog Diseases / pathology; Dogs; Female; Humans; Magnetic Resonance Imaging / veterinary
topics (OpenAlex): Fetal and Pediatric Neurological Disorders; Congenital heart defects research; Hedgehog Signaling Pathway Studies
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Source: Web Of Science
Added: August 6, 2018

2002 article

Use of vagal nerve stimulation as a treatment for refractory epilepsy in dogs

Muñana, K. R., Vitek, S. M., Tarver, W. B., Saito, M., Skeen, T. M., Sharp, N. J. H., … Haglund, M. M. (2002, October 1). Journal of the American Veterinary Medical Association, Vol. 221, pp. 977–983.

By: K. Muñana* , S. Vitek n, W. Tarver n, M. Saito n, T. Skeen n, N. Sharp n, N. Olby n , M. Haglund  n

Contributors: K. Muñana* , S. Vitek n, W. Tarver n, M. Saito n, T. Skeen n, N. Sharp n, N. Olby n , M. Haglund  n

MeSH headings : Animals; Cross-Over Studies; Dog Diseases / therapy; Dogs; Electric Stimulation Therapy / adverse effects; Electric Stimulation Therapy / methods; Electric Stimulation Therapy / veterinary; Epilepsy / therapy; Epilepsy / veterinary; Female; Male; Pacemaker, Artificial / veterinary; Safety; Seizures / prevention & control; Seizures / veterinary; Treatment Outcome; Vagus Nerve / physiopathology
topics (OpenAlex): Vagus Nerve Stimulation Research; EEG and Brain-Computer Interfaces; Neuroscience and Neural Engineering
TL;DR: Vagal nerve stimulation is a potentially safe approach to seizure control that appears to be efficacious in certain dogs and should be considered a possible treatment option when antiepileptic medications are ineffective. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2002 article

What Is Your Neurologic Diagnosis?

Higgins, M. A., & Sharp, N. J. H. (2002, November 1). Journal of the American Veterinary Medical Association.

By: M. Higgins  n & N. Sharp*

MeSH headings : Animals; Cerebral Hemorrhage / diagnosis; Cerebral Hemorrhage / drug therapy; Cerebral Hemorrhage / veterinary; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dogs; Hemophilia A / complications; Hemophilia A / veterinary; Male; Meninges / pathology; Pain / etiology; Pain / veterinary; Prognosis; Treatment Outcome
topics (OpenAlex): Neurological diseases and metabolism; Hereditary Neurological Disorders; Veterinary Orthopedics and Neurology
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Source: Web Of Science
Added: August 6, 2018

2001 journal article

Characterization of a canine model of mucopolysaccharidosis IIIB.

American Journal of Human Genetics, 69(4), 1760.

By: N. Ellinwood, P. Wang, T. Skeen, N. Sharp, M. Cesta, W. Bush, E. Hardam, M. Haskins, U. Giger

Source: NC State University Libraries
Added: August 6, 2018

2001 article

Development of a functional scoring system in dogs with acute spinal cord injuries

Olby, N. J., Risio, L. D., Muñana, K. R., Wosar, M. A., Skeen, T. M., Sharp, N. J. H., & Keene, B. W. (2001, October 1). American Journal of Veterinary Research, Vol. 62, pp. 1624–1628.

By: N. Olby* , L. Risio  n, K. Muñana n , M. Wosar n, T. Skeen n, N. Sharp n, B. Keene n

Contributors: N. Olby* , L. De Risio  n, K. Muñana n , M. Wosar n, T. Skeen n, N. Sharp n, B. Keene n

MeSH headings : Animals; Dog Diseases / physiopathology; Dogs; Gait / physiology; Hindlimb / physiopathology; Intervertebral Disc Displacement / physiopathology; Intervertebral Disc Displacement / veterinary; Observer Variation; Paraplegia / etiology; Paraplegia / veterinary; Reproducibility of Results; Severity of Illness Index; Spinal Cord Diseases / complications; Spinal Cord Diseases / physiopathology; Spinal Cord Diseases / veterinary; Statistics, Nonparametric; Videotape Recording
topics (OpenAlex): Veterinary Orthopedics and Neurology; Spinal Cord Injury Research; Shoulder Injury and Treatment
TL;DR: Pelvic limb gait of dogs recovering from thoracolumbar spinal cord injuries can be reliably quantified, using a numeric scale, and this scale will facilitate the performance of clinical trials aimed at improving the outcome of acute spinal Cord injuries. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2001 article

Evaluation of the dystrophin–glycoprotein complex, α-actinin, dysferlin and calpain 3 in an autosomal recessive muscular dystrophy in Labrador retrievers

Olby, N. J., Sharp, N. J. H., Anderson, L. V. B., Kunkel, L. M., & Bönnemann, C. G. (2001, January 1). Neuromuscular Disorders, Vol. 11, pp. 41–49.

By: N. Olby n , N. Sharp n, L. Anderson*, L. Kunkel * & C. Bönnemann *

author keywords: autosomal recessive muscular dystrophy in Labrador retrievers; limb-girdle muscular dystrophy; congenital muscular dystrophy; sarcoglycan; merosin; calpain 3; dysferlin
MeSH headings : Actinin / metabolism; Animals; Calpain / metabolism; Dog Diseases / metabolism; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Dysferlin; Dystrophin / metabolism; Female; Genes, Recessive / genetics; Glycoproteins / metabolism; Male; Membrane Proteins; Muscle Proteins / metabolism; Muscle, Skeletal / metabolism; Muscle, Skeletal / pathology; Muscle, Skeletal / physiopathology; Muscular Dystrophy, Animal / metabolism; Muscular Dystrophy, Animal / pathology; Muscular Dystrophy, Animal / physiopathology
topics (OpenAlex): Muscle Physiology and Disorders; Calpain Protease Function and Regulation; Nerve injury and regeneration
TL;DR: The results demonstrate that dystrophin, the sarcoglycans, alpha-actinin, dysferlin and calpain 3 are present in the normal and affected dogs, and it is concluded that this autosomal recessive muscular dystrophy is not due to a deficiency ofalpha-act inin, or any of the known autosome recessive limb-girdle muscular dystroke proteins, although it cannot rule out a malfunction of any of these proteins. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 article

Intervertebral disk disease in 10 cats

Munana, K. R., Olby, N. J., Sharp, N. J., & Skeen, T. M. (2001, July 1). Journal of the American Animal Hospital Association, Vol. 37, pp. 384–389.

By: K. Munana n , N. Olby* , N. Sharp* & T. Skeen*

Contributors: K. Muñana n , N. Olby* , N. Sharp* & T. Skeen*

MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cat Diseases / epidemiology; Cat Diseases / pathology; Cats; Female; Intervertebral Disc; Lumbar Vertebrae; Male; North Carolina / epidemiology; Radiography; Records / veterinary; Retrospective Studies; Spinal Diseases / diagnostic imaging; Spinal Diseases / epidemiology; Spinal Diseases / pathology; Spinal Diseases / veterinary
topics (OpenAlex): Veterinary Orthopedics and Neurology; Spine and Intervertebral Disc Pathology; Veterinary Equine Medical Research
TL;DR: The medical records of 10 cats diagnosed with intervertebral disk disease were reviewed, and all cats judged to have an excellent outcome had undergone surgical decompression. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2001 article

Predictors of outcome after dorsal decompressive laminectomy for degenerative lumbosacral stenosis in dogs: 69 cases (1987–1997)

Risio, L. D., Sharp, N. J., Olby, N. J., Muñana, K. R., & Thomas, W. B. (2001, September 1). Journal of the American Veterinary Medical Association, Vol. 219, pp. 624–628.

By: L. Risio *, N. Sharp*, N. Olby* , K. Muñana*  & W. Thomas

Contributors: L. De Risio *, N. Sharp*, N. Olby* , K. Muñana*  & W. Thomas

MeSH headings : Animals; Decompression, Surgical / veterinary; Dog Diseases / surgery; Dogs; Female; Follow-Up Studies; Laminectomy / veterinary; Lumbosacral Region / surgery; Male; Medical Records; Prognosis; Retrospective Studies; Spinal Stenosis / complications; Spinal Stenosis / surgery; Spinal Stenosis / veterinary; Surveys and Questionnaires; Treatment Outcome; Urinary Incontinence / complications; Urinary Incontinence / veterinary
topics (OpenAlex): Veterinary Orthopedics and Neurology; Veterinary Equine Medical Research; Spine and Intervertebral Disc Pathology
TL;DR: Decompressive laminectomy is an effective treatment for DLSS, although dogs with urinary or fecal incontinence have a worse prognosis than dogs that are continent before surgery. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2001 article

Risk factors for development of status epilepticus in dogs with idiopathic epilepsy and effects of status epilepticus on outcome and survival time: 32 cases (1990–1996)

Saito, M., Muñana, K. R., Sharp, N. J. H., & Olby, N. J. (2001, September 1). Journal of the American Veterinary Medical Association, Vol. 219, pp. 618–623.

By: M. Saito*, K. Muñana n , N. Sharp n & N. Olby n 

Contributors: M. Saito*, K. Muñana n , N. Sharp n & N. Olby n 

MeSH headings : Animals; Anticonvulsants / therapeutic use; Body Weight; Dog Diseases / diagnosis; Dog Diseases / etiology; Dog Diseases / mortality; Dogs; Epilepsy / complications; Epilepsy / mortality; Epilepsy / veterinary; Female; Male; Records / veterinary; Retrospective Studies; Risk Factors; Seizures / complications; Seizures / mortality; Seizures / veterinary; Status Epilepticus / etiology; Status Epilepticus / mortality; Status Epilepticus / veterinary; Treatment Outcome
topics (OpenAlex): Epilepsy research and treatment; Pharmacological Effects and Toxicity Studies; Metabolism and Genetic Disorders
TL;DR: Results suggest that a substantial percentage of dogs with idiopathic epilepsy will have episodes of SE, and dogs with greater body weights were more likely to have episodes, and early appropriate seizure treatment did not appear to decrease the risk that dogs would have episodes. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2000 article

Degenerative Lumbosacral Stenosis

Risio, L. D., Thomas, W. B., & Sharp, N. J. H. (2000, January 1). Veterinary Clinics of North America Small Animal Practice.

By: L. Risio  n, W. Thomas n & N. Sharp n

MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / therapy; Cats; Diagnosis, Differential; Dog Diseases / diagnosis; Dog Diseases / therapy; Dogs; Magnetic Resonance Imaging / veterinary; Myelography / veterinary; Polyradiculopathy / diagnosis; Polyradiculopathy / therapy; Polyradiculopathy / veterinary; Spinal Stenosis / diagnosis; Spinal Stenosis / therapy; Spinal Stenosis / veterinary; Tomography, X-Ray Computed / veterinary
topics (OpenAlex): Veterinary Orthopedics and Neurology; Spine and Intervertebral Disc Pathology; Veterinary Equine Medical Research
TL;DR: This article reviews the management of degenerative lumbosacral stenosis in dogs of medium to large breed and concludes that decompressive surgery is effective in most patients. (via Semantic Scholar)
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2000 chapter

Molecular biology of infectious disease

In Kirk's current veterinary therapy : small animal practice (13th Ed.) (p. 246). Philadelphia, PA : W.B. Saunders.

By: N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

2000 article

PRIMARY IRRADIATION OF CANINE INTRACRANIAL MASSES

Spugnini, E. P., Thrall, D. E., Price, G. S., Sharp, N. J., Munana, K., & Page, R. L. (2000, July 1). Veterinary Radiology & Ultrasound, Vol. 41, pp. 377–380.

By: E. Spugnini, D. Thrall*, G. Price n, N. Sharp n, K. Munana n  & R. Page n

Contributors: E. Spugnini, D. Thrall*, G. Price n, N. Sharp n, K. Munana n  & R. Page n

author keywords: dog; brain tumor; radiation therapy
MeSH headings : Animals; Brain Neoplasms / diagnostic imaging; Brain Neoplasms / mortality; Brain Neoplasms / radiotherapy; Brain Neoplasms / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Female; Glioma / diagnostic imaging; Glioma / mortality; Glioma / radiotherapy; Glioma / veterinary; Male; Meningeal Neoplasms / diagnostic imaging; Meningeal Neoplasms / mortality; Meningeal Neoplasms / radiotherapy; Meningeal Neoplasms / veterinary; Radiography; Radiotherapy / veterinary
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Hepatocellular Carcinoma Treatment and Prognosis; Veterinary Oncology Research
TL;DR: Radiation therapy is superior to medical treatment of brain tumors in dogs with steroids, is useful for tumors that are not currently operable and may be preferable to surgical resection in dogs if the mass appears infiltrative, however, 22/29 (76%) dogs died of recurrent progressive neuropathy suggestive of tumor regrowth or progression. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2000 journal article

The computed tomographic appearance of acute thoracolumbar intervertebral disk herniations in dogs.

Veterinary Radiology Ultrasound, 41(5), 396–402.

By: N. Olby* , K. Muntana* , N. Sharp* & D. Thrall n

Contributors: N. Olby* , K. Muñana* , N. Sharp* & D. Thrall n

author keywords: intervertebral disc herniation; computed tomography; myelography; epidural hemorrhage; dog
MeSH headings : Animals; Diskectomy; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs; Hematoma, Epidural, Cranial / veterinary; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Myelography; Spinal Cord / pathology; Tomography, X-Ray Computed
topics (OpenAlex): Veterinary Orthopedics and Neurology; Spine and Intervertebral Disc Pathology; Shoulder Injury and Treatment
TL;DR: In dogs with a long standing history of disc herniations, disc material identified in the vertebral canal had a more hyperattenuating and homogeneous appearance than recently herniated disc material. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
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2000 journal article

Urinary incontinence on dogs and cats. I. Measurement of urethral pressure. A review / L'incontinenza urinaria nel cane e nel gatto. Parte I -- profilometria della pressione uretrale

Veterinaria, 14(2), 33.

By: J. Gookin , E. Stone & N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Urinary incontinence on dogs and cats. II. Diagnosis and treatment. A review / L'incontinenza urinaria nel cane e nel gatto. Parte II -- diagnosi e trattamento

Veterinaria, 14(2), 43.

By: J. Gookin , E. Stone & N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

1999 article

A description of cutaneous-subcutaneous pythiosis in fifteen dogs

Dykstra, M. J., Sharp, N. J. H., Olivry, T., Hillier, A., Murphy, K. M., Kaufman, L., … Pucheu-Haston, C. (1999, December 1). Medical Mycology, Vol. 37, pp. 427–433.

By: M. Dykstra n, N. Sharp*, T. Olivry* , A. Hillier, K. Murphy* , L. Kaufman, G. Kunkle, C. Pucheu-Haston

Contributors: M. Dykstra n, N. Sharp*, T. Olivry* , A. Hillier, K. Murphy* , L. Kaufman, G. Kunkle, C. Pucheu-Haston

author keywords: canine; diagnosis; pythiosis; therapy
MeSH headings : Animals; Dermatomycoses / diagnosis; Dermatomycoses / pathology; Dermatomycoses / veterinary; Dog Diseases / diagnosis; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Female; Male; Pythium / isolation & purification
topics (OpenAlex): Infectious Diseases and Mycology; Veterinary Oncology Research; Mycobacterium research and diagnosis
TL;DR: The prognosis for cutaneous pythiosis in the dog is poor and Histopathological evaluation using the Gomori Methenamine-Silver (GMS) stain was the most useful test for providing presumptive evidence of cutaneouspythiosis. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1999 journal article

A polymerase chain reaction screening strategy for the promoter of the canine dystrophin gene

American Journal of Veterinary Research, 60(9), 1040–1046.

By: S. Schatzberg, N. Olby , S. Steingold, B. Keene, C. Atkins, K. Meurs, G. Solomon, S. Goedegebuure, S. Wilton, N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Chronic and Acute Compressive Spinal Cord Lesions in Dogs due to Intervertebral Disc Herniation Are Associated With Elevation in Lumbar Cerebrospinal Fluid Glutamate Concentration

Journal of Neurotrauma, 16(12), 1215–1224.

By: N. Olby n , N. Sharp*, K. Muñana*  & M. Papich* 

Contributors: N. Olby n , N. Sharp*, K. Muñana*  & M. Papich* 

author keywords: cerebrospinal fluid; dog; excitotoxicity; glutamate; spinal-cord compression; spinal cord injury
MeSH headings : Acute Disease; Animals; Chronic Disease; Dogs; Glutamic Acid / cerebrospinal fluid; Intervertebral Disc Displacement / complications; Lumbar Vertebrae; Lumbosacral Region; Osmolar Concentration; Reference Values; Spinal Cord Injuries / cerebrospinal fluid; Spinal Cord Injuries / etiology; Thoracic Vertebrae
topics (OpenAlex): Veterinary Orthopedics and Neurology; Spinal Cord Injury Research; Spinal Dysraphism and Malformations
TL;DR: Dogs with chronic compressive thoracolumbar lesions have a two-fold elevation of CSF glutamate concentration, suggesting that excitotoxicity may also be a component of chronic spinal cord compression. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

1999 article

Hydranencephaly and Cerebellar Hypoplasia in Two Kittens Attributed to Intrauterine Parvovirus Infection

Sharp, N. J. H., Davis, B. J., Guy, J. S., Cullen, J. M., Steingold, S. F., & Kornegay, J. N. (1999, July 1). Journal of Comparative Pathology, Vol. 121, pp. 39–53.

By: N. Sharp n, B. Davis *, J. Guy n , J. Cullen n, S. Steingold n & J. Kornegay*

MeSH headings : Animals; Brain / abnormalities; Brain / virology; Cat Diseases / pathology; Cat Diseases / virology; Cats; Cerebellum / pathology; Cerebellum / virology; Cytopathogenic Effect, Viral; Female; Hydranencephaly / pathology; Hydranencephaly / veterinary; Hydranencephaly / virology; Parvoviridae Infections / complications; Parvoviridae Infections / pathology; Parvoviridae Infections / veterinary; Parvovirus; Polymerase Chain Reaction / veterinary; Pregnancy; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / adverse effects; Viral Vaccines / administration & dosage; Viral Vaccines / adverse effects
topics (OpenAlex): Fetal and Pediatric Neurological Disorders; Urological Disorders and Treatments; Parvovirus B19 Infection Studies
TL;DR: Six weeks after vaccination with modified live feline parvovirus vaccine, a cat gave birth to five kittens, three of which died soon afterwards, and two kittens survived, but at 8 weeks of age were unable to walk and showed abnormal behaviour, which suggested multifocal disease associated with the cerebrum and cerebellum. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 article

Molecular analysis of a spontaneous dystrophin `knockout' dog

Schatzberg, S. J., Olby, N. J., Breen, M., Anderson, L. V. B., Langford, C. F., Dickens, H. F., … Sharp, N. J. H. (1999, July 1). Neuromuscular Disorders, Vol. 9, pp. 289–295.

By: S. Schatzberg n, N. Olby n , M. Breen* , L. Anderson*, C. Langford*, H. Dickens*, S. Wilton *, C. Zeiss * ...

Contributors: S. Schatzberg n, N. Olby n , M. Breen* , L. Anderson*, C. Langford*, H. Dickens*, S. Wilton *, C. Zeiss * ...

author keywords: dystrophin; Duchenne muscular dystrophy; canine; animal models; fluorescence in situ hybridization; polymerase chain reaction
MeSH headings : Animals; Biopsy; Blotting, Western; Chromosome Deletion; Creatine Kinase / blood; DNA / genetics; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Dystrophin / genetics; In Situ Hybridization, Fluorescence; Male; Muscle, Skeletal / metabolism; Muscle, Skeletal / pathology; Muscular Dystrophy, Animal / genetics; Muscular Dystrophy, Animal / pathology; Mutation; Polymerase Chain Reaction; X Chromosome / genetics
topics (OpenAlex): Muscle Physiology and Disorders; Adipose Tissue and Metabolism; Silk-based biomaterials and applications
TL;DR: The molecular basis for skeletal myopathy and dilated cardiomyopathy in two male German short-haired pointer (GSHP) littermates is determined and a visible deletion in the p21 region of the affected canine X chromosome is confirmed. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

1998 journal article

A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer

Cancer Research, 58(15), 3353–3361.

By: S. Dunn, M. Ehrlich, N. Sharp, K. Reiss, G. Solomon, R. Hawkins, R. Baserga, C. Barrett

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Alternative dystrophin gene transcripts in golden retriever muscular dystrophy

Muscle and Nerve, 21(8), 991–998.

By: S. Schatzberg, L. Anderson, S. Wilton, J. Kornegay, C. Mann, G. Solomon, N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Characterization of canine MDR1 mRNA: Its abundance in drug resistant cell lines and in vivo

Anticancer Research, 18(1A), 393–400.

By: S. Steingold, N. Sharp, M. McGahan, C. Hughes, S. Dunn & R. Page

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Putting "wobblers" back on track - Part II

Veterinary Technician, 19(8), 519–526.

By: J. Osborne & N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Cytologic and Histologic Features of a Poorly Differentiated Glioma in a Dog

Fernandez, F. R., Grindem, C. B., Brown, T. T., Sharp, N. J. H., & Saulnier, M. (1997, December 1). Veterinary Clinical Pathology.

By: F. Fernandez*, C. Grindem n, T. Brown n, N. Sharp n & M. Saulnier n

author keywords: cytology; immunocytochemistry; glioma; spinal cord; ependymoma; dog
topics (OpenAlex): Glioma Diagnosis and Treatment; Hedgehog Signaling Pathway Studies; Neurological diseases and metabolism
TL;DR: A 5-year old female Boxer with a 1-week history of progressive paresis and paraplegia had a T10-13 subarachnoid filling defect on myelography, which was subsequently diagnosed as a poorly differentiated glioma, most likely an anaplastic ependymoma. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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