Works (2)

Updated: July 5th, 2023 15:50

2010 journal article

Congenital Hepatic Fibrosis in 5 Dogs


By: D. Brown n, T. Van Winkle*, T. Cecere n, S. Rushton*, C. Brachelente* & J. Cullen n

author keywords: bile ducts; biliary tract diseases; canine; embryonic development; liver
MeSH headings : Animals; Bile Ducts / pathology; Dog Diseases / congenital; Dog Diseases / pathology; Dogs; Female; Liver / pathology; Liver Cirrhosis / congenital; Liver Cirrhosis / pathology; Liver Cirrhosis / veterinary; Male; Proliferating Cell Nuclear Antigen / metabolism
TL;DR: Congenital hepatic fibrosis should be considered in the differential diagnosis in young dogs that present with portal hypertension and lesions that may have been interpreted as bridging biliary hyperplasia or extrahepatic biliary obstruction. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 journal article

Aflatoxin B1 and/or Hepatitis B Virus Induced Tumor Spectrum in a Genetically Engineered Hepatitis B Virus Expression and Trp53 Haploinsufficient Mouse Model System for Hepatocarcinogenesis


By: J. Cullen n, D. Brown n, G. Kissling*, J. Foley*, J. Rizzo n, P. Marion*, V. Parron*, J. French*

author keywords: aflatoxin B-1; hepatitis B virus; hepatocellular carcinoma; p53; transgenic; Trp53; tumorigenesis; FVB/N strain
MeSH headings : Aflatoxin B1 / genetics; Animals; Disease Models, Animal; Female; Genetic Engineering / adverse effects; Hepatitis B Surface Antigens / genetics; Hepatitis B virus / genetics; Immunohistochemistry; Kaplan-Meier Estimate; Ki-67 Antigen / genetics; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / pathology; Liver Neoplasms, Experimental / virology; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Sex Factors; Survival Analysis; Tumor Suppressor Protein p53 / genetics
TL;DR: In this model system, HBV expression affected only hepatocellular neoplasia in association with both aflatoxin B1 initiation and p53 haploinsufficiency, and the HBV transgene increased the risk of sarcoma in males and females. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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