Michael C. Weiger

Works (3)

Updated: July 5th, 2023 15:51

2011 journal article

Poly(vinylmethylsiloxane) Elastomer Networks as Functional Materials for Cell Adhesion and Migration Studies

BIOMACROMOLECULES, 12(4), 1265–1271.

By: S. Ahmed n, H. Yang n, A. Ozcam n, K. Efimenko n , M. Weiger n, J. Genzer n , J. Haugh n 

MeSH headings : Amino Acid Sequence; Animals; Cell Adhesion; Cell Movement; Mice; Microscopy, Fluorescence; Molecular Sequence Data; NIH 3T3 Cells; Oligopeptides / chemistry; Polyvinyls / chemistry; Siloxanes / chemistry
TL;DR: These experiments show that a peptide containing the synergy sequence of fibronectin (PHSRN) in addition to RGD promotes more productive cell migration without markedly enhancing cell adhesion strength. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 journal article

Directional Persistence of Cell Migration Coincides with Stability of Asymmetric Intracellular Signaling

BIOPHYSICAL JOURNAL, 98(1), 67–75.

By: M. Weiger n, S. Ahmed n, E. Welf n & J. Haugh n 

MeSH headings : Animals; Cell Movement / physiology; Computer Simulation; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Signal Transduction / physiology
TL;DR: Analysis of phosphoinositide 3-kinase signaling in randomly migrating fibroblasts shows that hot spots of intense signaling coincide with localized cell protrusion and endure with characteristic lifetimes that correspond to those of cell migration persistence, and shows that distant hot spots are dynamically and stochastically coupled. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

JOURNAL OF CELL SCIENCE, 122(3), 313–323.

By: M. Weiger n, C. Wang n, M. Krajcovic n, A. Melvin n, J. Rhoden n & J. Haugh n 

author keywords: Cell migration; Phosphoinositide 3-kinase; Integrin; Fibronectin; Adhesion
MeSH headings : Actins / antagonists & inhibitors; Actins / metabolism; Animals; Chemotaxis / physiology; Cytochalasin D / pharmacology; Cytoskeleton / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Fibroblasts / physiology; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Mice; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Pseudopodia / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / physiology
TL;DR: Live-cell imaging using total internal reflection fluorescence (TIRF) microscopy revealed that, in the absence of soluble cues, 3′-phosphoinositides are enriched in a localized and dynamic fashion during active spreading and random migration of mouse fibroblasts on adhesive surfaces. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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