Works (3)
Updated: July 5th, 2023 15:51
2011 article
PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk (vol 5, pg 246, 2009)
Wang, C.-C., Cirit, M., & Haugh, J. M. (2011, August). MOLECULAR SYSTEMS BIOLOGY, Vol. 7.
TL;DR:
The effects of expressing wild-type and genuine G12V H-Ras in the authors' cells, using the samemethods as in the published article, are presented.
(via Semantic Scholar)
msb.embopress.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (ERK) Signaling Network
JOURNAL OF BIOLOGICAL CHEMISTRY, 285(47), 36736–36744.
MeSH headings : Animals; Extracellular Signal-Regulated MAP Kinases / metabolism; Feedback, Physiological; Humans; Immunoblotting; Kinetics; Mice; Mitogen-Activated Protein Kinases / metabolism; NIH 3T3 Cells; Phosphorylation; Signal Transduction; ras Proteins / metabolism
TL;DR:
This work takes a systematic approach to parse the magnitudes of multiple regulatory mechanisms that attenuate ERK activation through canonical (Ras- dependent) and non-canonical (PI3K-dependent) pathways and demonstrates that kinetic models of signaling networks, trained on a sufficient diversity of quantitative data, can be reasonably comprehensive, accurate, and predictive in the dynamical sense.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts
JOURNAL OF CELL SCIENCE, 122(3), 313–323.
author keywords: Cell migration; Phosphoinositide 3-kinase; Integrin; Fibronectin; Adhesion
MeSH headings : Actins / antagonists & inhibitors; Actins / metabolism; Animals; Chemotaxis / physiology; Cytochalasin D / pharmacology; Cytoskeleton / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Fibroblasts / physiology; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Mice; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Pseudopodia / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / physiology
TL;DR:
Live-cell imaging using total internal reflection fluorescence (TIRF) microscopy revealed that, in the absence of soluble cues, 3′-phosphoinositides are enriched in a localized and dynamic fashion during active spreading and random migration of mouse fibroblasts on adhesive surfaces.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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