Works (2)

Updated: July 5th, 2023 15:51

2010 journal article

Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells


By: M. Cirit n, M. Krajcovic n, C. Choi*, E. Welf n, A. Horwitz* & J. Haugh n

Ed(s): A. Asthagiri

MeSH headings : Animals; CHO Cells; Cell Adhesion / physiology; Cell Movement / physiology; Cell Surface Extensions / metabolism; Computational Biology / methods; Computer Simulation; Cricetinae; Cricetulus; Extracellular Matrix / metabolism; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Integrins / metabolism; Models, Biological; Myosins / metabolism; Paxillin / genetics; Paxillin / metabolism; Signal Transduction / physiology; Stochastic Processes; rac GTP-Binding Proteins / metabolism
TL;DR: This work has formulated a quantitative model of leading edge dynamics combining mechanistic and phenomenological elements and studied its features through classical bifurcation analysis and stochastic simulation, showing that the qualitative behavior of the model is most sensitive to parameters characterizing the influence of stable adhesion and myosin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

JOURNAL OF CELL SCIENCE, 122(3), 313–323.

By: M. Weiger n, C. Wang n, M. Krajcovic n, A. Melvin n, J. Rhoden n & J. Haugh n

author keywords: Cell migration; Phosphoinositide 3-kinase; Integrin; Fibronectin; Adhesion
MeSH headings : Actins / antagonists & inhibitors; Actins / metabolism; Animals; Chemotaxis / physiology; Cytochalasin D / pharmacology; Cytoskeleton / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Fibroblasts / physiology; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Mice; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Pseudopodia / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / physiology
TL;DR: Live-cell imaging using total internal reflection fluorescence (TIRF) microscopy revealed that, in the absence of soluble cues, 3′-phosphoinositides are enriched in a localized and dynamic fashion during active spreading and random migration of mouse fibroblasts on adhesive surfaces. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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