R. Aaron Garner

Works (2)

Updated: July 5th, 2023 15:51

2010 journal article

Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos

Journal of the American Chemical Society, 132(44), 15644–15650.

By: A. Deiters n, R. Garner n, H. Lusic n, J. Govan n, M. Dush n, N. Nascone-Yoder n , J. Yoder n 

MeSH headings : Animals; Cells, Cultured; Embryo, Nonmammalian / metabolism; Gene Expression; Morpholines / chemistry; Oligonucleotides / genetics; Oligonucleotides / metabolism; Ultraviolet Rays; Xenopus laevis / genetics; Xenopus laevis / metabolism; Zebrafish / genetics; Zebrafish / metabolism
TL;DR: A novel and efficient synthetic route for incorporating photocaged monomeric building blocks directly into morpholino oligomers is reported and the utility of these caged morpholinos in the light-activated control of gene function in both cell culture and living embryos is demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2008 journal article

Light-activation of gene function in mammalian cells via ribozymes

Chem. Commun., (5), 568–570.

By: D. Young n, R. Garner n, J. Yoder n  & A. Deiters n

MeSH headings : Cell Line; Gene Expression / radiation effects; Humans; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; RNA, Messenger / metabolism; Toyocamycin / chemistry; Toyocamycin / radiation effects; Ultraviolet Rays
TL;DR: A ribozyme based gene control element enabled the spatio-temporal regulation of gene function in mammalian cell culture with light. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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