Works (4)

Updated: July 5th, 2023 16:02

2005 journal article

Expression of the cercosporin transporter, CFP, in tobacco reduces frog-eye lesion size

BIOTECHNOLOGY LETTERS, 27(20), 1543–1550.

By: R. Upchurch n, M. Rose n, M. Eweida n & W. Zuo n

author keywords: cercosporin; frog-eye leaf spot; major facilitator; plant genetic engineering; toxin efflux
MeSH headings : Ascomycota / genetics; Fungal Proteins / biosynthesis; Fungal Proteins / genetics; Membrane Transport Proteins / biosynthesis; Membrane Transport Proteins / genetics; Plant Diseases / genetics; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism; Tobacco / genetics; Tobacco / metabolism
TL;DR: It is concluded that transgenic expression of CFP may have relevance for a disease control strategy in Cercospora-plant pathosystems where cercosporin is implicated in pathogen virulence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Transgenic assessment of CFP-mediated cercosporin export and resistance in a cercosporin-sensitive fungus

CURRENT GENETICS, 41(1), 25–30.

By: R. Upchurch n, M. Rose n, M. Eweida n & T. Callahan n

author keywords: cercosporin resistance; major facilitator; heterologous gene expression
MeSH headings : Antifungal Agents / pharmacology; Ascomycota / genetics; Ascomycota / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Drug Resistance, Fungal / genetics; Fungal Proteins; Membrane Transport Proteins; Organisms, Genetically Modified; Perylene / analogs & derivatives; Perylene / pharmacology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Over-expression of the cercosporin facilitator protein, CFP, in Cercospora kikuchii up-regulates production and secretion of cercosporin

FEMS MICROBIOLOGY LETTERS, 204(1), 89–93.

By: R. Upchurch n, M. Rose n & M. Eweida n

author keywords: cercosporin; CFP; major facilitator; over-expression; resistance; Cercospora kikuchii
MeSH headings : Ascomycota / drug effects; Ascomycota / genetics; Ascomycota / pathogenicity; Ascomycota / physiology; Carrier Proteins / genetics; Carrier Proteins / metabolism; Drug Resistance, Fungal; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Fungal Proteins; Gene Deletion; Gene Dosage; Gene Expression Regulation, Fungal; Immunoblotting; Membrane Transport Proteins; Perylene / analogs & derivatives; Perylene / metabolism; Perylene / pharmacology; Soybeans / microbiology; Transcription, Genetic; Up-Regulation
TL;DR: The three-fold increase in toxin accumulation, predominantly associated with the mycelium fraction of these CFP multi-copy strains, suggests that CFP may also have a significant, but unknown, role in regulating toxin production. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

CFP, the putative cercosporin transporter of Cercospora kikuchii, is required for wild type cercosporin production, resistance, and virulence on soybean

MOLECULAR PLANT-MICROBE INTERACTIONS, 12(10), 901–910.

By: T. Callahan, M. Rose*, M. Meade, M. Ehrenshaft* & R. Upchurch*

author keywords: drug/proton antiporter
MeSH headings : Amino Acid Sequence; Ascomycota / genetics; Ascomycota / pathogenicity; Ascomycota / physiology; Base Sequence; Carrier Proteins / genetics; Carrier Proteins / metabolism; DNA, Fungal / genetics; Fungal Proteins / genetics; Fungal Proteins / metabolism; Genetic Complementation Test; Membrane Transport Proteins; Molecular Sequence Data; Open Reading Frames; Perylene / analogs & derivatives; Perylene / metabolism; Sequence Alignment; Sequence Homology, Amino Acid; Soybeans / microbiology; Virulence
TL;DR: It is proposed that CFP (cercosporin facilitator protein) encodes a cercosporin transporter that contributes resistance to cercOSporin by actively exporting cercsporin, thus maintaining low cellular concentrations of the toxin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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