Works (13)
Updated: July 14th, 2023 21:14
2014 journal article
Leishmanicidal activity of a daucane sesquiterpene isolated from Eryngium foetidum
PHARMACEUTICAL BIOLOGY, 52(3), 398–401.
Contributors: P. Rojas-Silva *, R. Graziose*, B. Vesely *, A. Poulev*, n, M. Grace n , D. Kyle *, M. Lila n , I. Raskin *
author keywords: Apiaceae; bioassay guided fractionation; cytotoxicity; leishmaniasis; LC-MS; NMR; sesquiterpenoids
MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / isolation & purification; Antiprotozoal Agents / pharmacology; Cell Line; Chromatography / methods; Chromatography, High Pressure Liquid / methods; Eryngium / chemistry; Inhibitory Concentration 50; Leishmania / drug effects; Leishmania donovani / drug effects; Magnetic Resonance Spectroscopy / methods; Mass Spectrometry / methods; Myoblasts / drug effects; Myoblasts / metabolism; Myoblasts, Skeletal / drug effects; Myoblasts, Skeletal / metabolism; Plant Components, Aerial; Rats; Sesquiterpenes / administration & dosage; Sesquiterpenes / isolation & purification; Sesquiterpenes / pharmacology; Toxicity Tests
TL;DR:
The bioassay-guided fractionation with the leishmanicidal and cytotoxicity activities of two compounds isolated for the first time from an Eryngium species were presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2013 journal article
Efficient Quantification of the Health-Relevant Anthocyanin and Phenolic Acid Profiles in Commercial Cultivars and Breeding Selections of Blueberries (Vaccinium spp.)
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(20), 4806–4815.
Contributors: G. Yousef n, A. Brown n, Y. Funakoshi n, n, M. Grace n , J. Ballington n, A. Loraine *, M. Lila n
author keywords: anthocyanins; chlorogenic acid; blueberry; HPLC-DAD-MS; Vaccinium spp.; freeze-drying; health benefits
MeSH headings : Anthocyanins / analysis; Blueberry Plants / chemistry; Breeding; Chromatography, High Pressure Liquid / methods; Food, Preserved / analysis; Frozen Foods / analysis; Fruit / chemistry; Genotype; Glucosides / analysis; Health Promotion; Humans; Hydroxybenzoates / analysis; Plant Extracts / chemistry; Species Specificity; Tandem Mass Spectrometry / methods
TL;DR:
An improved protocol was developed for the accurate, efficient, and rapid comparative screening for large blueberry sample sets and different genotypes frequently had comparable overall levels of total anthocyanins and phenolic acids, but differed dramatically in individual profiles of compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Comparison of Health-Relevant Flavonoids in Commonly Consumed Cranberry Products
JOURNAL OF FOOD SCIENCE, 77(8), H176–H183.
author keywords: anthocyanins; cranberry; flavonoids; proanthocyanidins; processing
MeSH headings : Anthocyanins / analysis; Beverages; Biflavonoids / analysis; Catechin / analysis; Chromatography, High Pressure Liquid; Flavonoids / analysis; Food Handling / methods; Freeze Drying; Fruit / chemistry; Plant Extracts / analysis; Proanthocyanidins / analysis; Vaccinium macrocarpon / chemistry
TL;DR:
As cranberry juices and other products are increasingly consumed for their recognized health benefits (including prophylaxis against urinary tract infection), it is relevant to consider how various degrees of commercial and home processing can alter innate levels of the biologically active flavonoids characteristic to the intact fruits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
In vitro antiplasmodial activity of indole alkaloids from the stem bark of Geissospermum vellosii
JOURNAL OF ETHNOPHARMACOLOGY, 139(2), 471–477.
Contributors: n, M. Grace n , C. Lategan*, P. Smith*, I. Raskin * & M. Lila n
author keywords: Geissospermum vellosii; Apocynaceae; Indole alkaloids; Antiplasmodial activity; Malaria
MeSH headings : Animals; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Antimalarials / toxicity; Apocynaceae / chemistry; CHO Cells; Cell Survival / drug effects; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Indole Alkaloids / chemistry; Indole Alkaloids / isolation & purification; Indole Alkaloids / pharmacology; Indole Alkaloids / toxicity; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Parasitic Sensitivity Tests; Plant Bark; Plants, Medicinal; Plasmodium falciparum / drug effects
TL;DR:
Evidence is provided to support the use of Geissospermum vellosii as an antimalarial agent, as used by the native populations, as part of the ongoing investigations of new bioactive compounds with activity against malaria parasites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Isolation and characterization of flavonols from blackcurrant by high-performance counter-current chromatography and electrospray ionization tandem mass spectrometry
JOURNAL OF SEPARATION SCIENCE, 35(13), 1682–1689.
Contributors: *, M. Grace* , G. Yousef* & M. Ann Lila n
author keywords: Blackcurrant (Ribes nigrum); Flavonols; High-performance counter-current chromatography; Liquid chromatography with tandem mass spectrometry
MeSH headings : Countercurrent Distribution / methods; Flavonols / chemistry; Flavonols / isolation & purification; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Ribes / chemistry; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
The results of these experiments demonstrated that high-performance counter-current chromatography along with ESI-MS(n) is a sensitive, selective, and effective technology for isolation and characterization of minor constituents from a complex mixture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2012 journal article
Isolation and structural elucidation of indole alkaloids from Geissospermum vellosii by mass spectrometry
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 885, 83–89.
Source: NC State University Libraries
Added: August 6, 2018
2012 conference paper
Seeking novel Leishmanicidal natural products from common medicinal plants, the example of Eryngium foetidum L
Planta Medica, 78(11), 1132–1132.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Investigation of solubilization and digestion methods for microsomal membrane proteome analysis using data-independent LC-MSE
PROTEOMICS, 11(5), 898–911.
author keywords: Bottom-up proteomics; Data-independent analysis; Denaturants; LC-MSE; Membrane proteomics; Technology
MeSH headings : Chromatography, Liquid; Guanidine / chemistry; Solanum lycopersicum / chemistry; Membrane Proteins / analysis; Membrane Proteins / chemistry; Membrane Proteins / metabolism; Methanol / chemistry; Microsomes / chemistry; Microsomes / enzymology; Peptide Fragments / analysis; Peptide Fragments / chemistry; Peptide Fragments / metabolism; Plant Roots / chemistry; Plant Roots / cytology; Proteome / analysis; Proteome / chemistry; Proteome / metabolism; Proteomics / methods; Solubility; Surface-Active Agents / chemistry; Tandem Mass Spectrometry; Trypsin / metabolism
TL;DR:
The results reveal the complementary nature of each denaturant method, which can be used in an integrated approach to provide a more effective bottom‐up analysis of membrane proteomes than can be achieved using only a singleDenaturant.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Isolation and identification of antiplasmodial N-alkylamides from Spilanthes acmella flowers using centrifugal partition chromatography and ESI-IT-TOF-MS
Journal of Chromatography B, 879(21), 1886–1892.
Contributors: n, M. Grace n , C. Lategan*, P. Smith*, I. Raskin * & M. Lila n
author keywords: Centrifugal partition chromatography; N-alkylamides; Antiplasmodial activity
MeSH headings : Amides / chemistry; Amides / isolation & purification; Amides / pharmacology; Animals; Antimalarials / chemistry; Antimalarials / isolation & purification; Antimalarials / pharmacology; Asteraceae / chemistry; CHO Cells; Cell Survival / drug effects; Centrifugation; Chromatography, Liquid / methods; Cricetinae; Cricetulus; Flowers / chemistry; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum / drug effects; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
A systematic approach for investigating a suitable centrifugal partition chromatography (CPC) solvent system for N-alkylamides separation was reported, and CPC fractions demonstrated significantly higher antiplasmodial activity compared to corresponding purified N-alkinglamides, thus suggesting that interactions between these N-alklamides may potentiate antiplAsmodial bioactivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2010 journal article
Antiplasmodial and cytotoxic activities of drimane sesquiterpenes from Canella winterana
Natural Product Communications, 5(12), 1869–1872.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Improving Protein and Proteome Coverage through Data-Independent Multiplexed Peptide Fragmentation
JOURNAL OF PROTEOME RESEARCH, 9(7), 3621–3637.
author keywords: Proteomics; mass spectrometry; protein characterization; data-independent acquisition (DIA); data-dependent acquisition (DDA); protein identification; LC/MSE
MeSH headings : Amino Acid Sequence; Animals; Arabidopsis Proteins / chemistry; Arabidopsis Proteins / metabolism; Artifacts; Cattle; Chromatography, Liquid / methods; Ions / chemistry; Solanum lycopersicum; Mass Spectrometry / methods; Molecular Sequence Data; Peptide Fragments / chemistry; Peptide Fragments / metabolism; Plant Leaves; Plant Proteins / chemistry; Plant Proteins / metabolism; Protein Kinases / chemistry; Protein Kinases / metabolism; Proteomics / methods; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / metabolism; Trypsin / metabolism
TL;DR:
The fundamental limitations of serial MS/MS interrogation are revealed and the advantages of parallel fragmentation by DIA for more comprehensive protein identification and characterization are revealed which holds promise for enhanced isoform and post-translational modification analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Proteomic and Bioinformatic Analysis of the Root-Knot Nematode Meloidogyne hapla: The Basis for Plant Parasitism
Journal of Proteome Research, 9(10), 5370–5381.
Contributors: n, E. Scholl n, C. Opperman n, M. Goshe n & D. Bird n
author keywords: LC/MSE; plant-parasite; nematode; data-independent acquisition; computational proteome
MeSH headings : Animals; Chromatography, Liquid; Computational Biology / methods; Databases, Protein; Genome, Helminth / genetics; Helminth Proteins / genetics; Helminth Proteins / metabolism; Humans; Internet; Plant Roots / parasitology; Proteomics / methods; Tandem Mass Spectrometry; Tylenchoidea / genetics; Tylenchoidea / metabolism
TL;DR:
To experimentally confirm the HapPep3 assignments using proteomics, a data-independent LC/MS(E) analysis to M. hapla protein extracts fractionated by SDS-PAGE was applied, and it was concluded that the identified proteins reflect a true and unbiased sampling of Happep3.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2009 review
Cancer and the tumor microenvironment: A review of an essential relationship
[Review of ]. Cancer Chemotherapy and Pharmacology, 63(4), 571–582.
Source: NC State University Libraries
Added: August 6, 2018
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