Kiyonori Kai

author keywords: Mesothelioma; Side population; Cancer stem cell; Hoechst 33342; Tumorigenicity; Flow cytometry

MeSH headings : Animals; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cisplatin / pharmacology; Feasibility Studies; Flow Cytometry; Gene Expression Regulation, Developmental; Humans; Mesothelioma / diagnosis; Mesothelioma / drug therapy; Mesothelioma / pathology; Mice; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells / drug effects; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology; Side-Population Cells / drug effects; Side-Population Cells / metabolism; Side-Population Cells / pathology

TL;DR: The data indicated that SP assay may not be appropriate for enriching putative CSCs in HMM cell lines, and thus warrants the development of a novel tool for mesothelial CSC study. (via Semantic Scholar)

author keywords: Malignant mesothelioma; Insulin-like growth factor 1 receptor; AG1024; Cisplatin; Chemoresistance

MeSH headings : Antineoplastic Agents / therapeutic use; Apoptosis / drug effects; Cell Division / drug effects; Cell Line, Tumor / drug effects; Cisplatin / therapeutic use; Humans; Mesothelioma / drug therapy; Pleural Neoplasms / drug therapy; Receptor, IGF Type 1 / antagonists & inhibitors; Signal Transduction / drug effects; Tyrphostins / therapeutic use

TL;DR: This study supports the conjecture that inhibition of the IGF-1R pathway may be a useful target for reducing toxicity and alleviating chemoresistance to traditional anticancer drugs in HMM patients. (via Semantic Scholar)