Works (1)
Updated: July 5th, 2023 15:50
2009 journal article
Functional implications of multistage copper binding to the prion protein
Proceedings of the National Academy of Sciences, 106(28), 11576–11581.
author keywords: copper attachment; hybrid DFT; misfolding; neurodegenerative diseases; metalloprotein
TL;DR:
The results show that copper attachment leads to rearrangement of the structure of the Cu-bonded octarepeat region and to development of turns in areas separating copper-bound residues that make the flexible N-terminal domain more rigid and thus more resistant to misfolding, suggesting that copper binding plays a beneficial role in the initial stages of prion diseases.
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www.pnas.org (publisher PDF)
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Added: August 6, 2018
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