Works (1)
Updated: July 5th, 2023 15:50
2009 journal article
Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 297(1), L164–L173.
author keywords: epithelium; interleukin-4; STAT6; IRS-1; IRS-2
MeSH headings : Air; Cell Differentiation / drug effects; Cell Line; Cell Movement / drug effects; DNA, Complementary / genetics; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Genes, Dominant; Humans; Insulin Receptor Substrate Proteins / metabolism; Interleukin-4 / pharmacology; Lung / cytology; Lung / pathology; Phosphorylation / drug effects; RNA, Small Interfering / metabolism; STAT6 Transcription Factor / metabolism
TL;DR:
It is demonstrated that IL-4 can accelerate migration of differentiated AEC after injury, and this reparative response does not require STAT6 activation, but rather requires IRS-1 and/or IRS-2.
(via Semantic Scholar)
open access via ajplung.physiology.org (publisher PDF)
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