Works (1)

Updated: July 5th, 2023 15:50

2009 journal article

Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells


By: S. White, L. Martin*, M. Abe, B. Marroquin, R. Stern & X. Fu*

author keywords: epithelium; interleukin-4; STAT6; IRS-1; IRS-2
MeSH headings : Air; Cell Differentiation / drug effects; Cell Line; Cell Movement / drug effects; DNA, Complementary / genetics; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Genes, Dominant; Humans; Insulin Receptor Substrate Proteins / metabolism; Interleukin-4 / pharmacology; Lung / cytology; Lung / pathology; Phosphorylation / drug effects; RNA, Small Interfering / metabolism; STAT6 Transcription Factor / metabolism
TL;DR: It is demonstrated that IL-4 can accelerate migration of differentiated AEC after injury, and this reparative response does not require STAT6 activation, but rather requires IRS-1 and/or IRS-2. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.