Rebecca Whittlesey

Works (1)

Updated: July 5th, 2023 15:49

2009 journal article

Differential Incorporation of Cholesterol by Sindbis Virus Grown in Mammalian or Insect Cells

JOURNAL OF VIROLOGY, 83(18), 9113–9121.

By: A. Hafer n, R. Whittlesey n, D. Brown n & R. Hernandez n

MeSH headings : Alphavirus Infections / etiology; Animals; Cell Line; Cell Membrane / chemistry; Cholesterol / analysis; Cholesterol / deficiency; Cholesterol / metabolism; Insecta; Lipids / analysis; Mammals; Mass Spectrometry; Sindbis Virus / metabolism; Sindbis Virus / pathogenicity
TL;DR: The cholesterol dependence reported for infectivity and assembly of Sindbis virus is a reflection of differences in the insect cell lines used and the methods of delipidation, and the amount of cholesterol in the host cell membrane in and of itself has no effect on the process of virus assembly or on the ability of virus to infect cells. (via Semantic Scholar)
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