I. Caballero

Works (1)

Updated: July 5th, 2023 15:49

2009 journal article

EVALUATION OF THE SERRATIA MARCESCENS NUCLEASE (NucA) AS A TRANSGENIC CELL ABLATION SYSTEM IN PORCINE

ANIMAL BIOTECHNOLOGY, 20(4), 177–185.

By: I. Caballero n & J. Piedrahita n 

author keywords: Ablation; DTA; Fibroblasts; NucA; Porcine
MeSH headings : Animals; Cell Separation / methods; Cells, Cultured; Electroporation / methods; Endodeoxyribonucleases / analysis; Endodeoxyribonucleases / genetics; Endodeoxyribonucleases / metabolism; Endoribonucleases / analysis; Endoribonucleases / genetics; Endoribonucleases / metabolism; Fibroblasts / metabolism; Gene Expression; Gene Transfer Techniques; Rabbits; Serratia / enzymology; Swine
TL;DR: Gene expression analysis of surviving colonies indicated that survival is related to low or absent expression of the toxic genes, and results indicate that the NucA gene, while capable of mammalian cell ablation, is less efficient than DTA. (via Semantic Scholar)
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Added: August 6, 2018

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