Works (12)
Updated: July 7th, 2023 09:30
2017 journal article
Optimizing ultrasound molecular imaging of secreted frizzled related protein 2 expression in angiosarcoma
PLOS ONE, 12(3).
MeSH headings : Animals; Avidin / metabolism; Biomarkers, Tumor / metabolism; Cell Line, Tumor; Contrast Media / metabolism; Hemangiosarcoma / metabolism; Humans; Membrane Proteins / metabolism; Membrane Proteins / ultrastructure; Mice, Nude; Microbubbles; Molecular Imaging / methods; Neoplasm Transplantation; Ultrasonography / methods
TL;DR:
Basing the targeted contrast on NeutrAvidin™-functionalized microbubbles, using IgY antibodies for the authors' control contrast, and optimizing the imaging protocol significantly increased the SFRP2-specific signal returned from angiosarcoma vasculature, and may provide new opportunities for targeted molecular imaging.
(via Semantic Scholar)
open access via journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Ultrasound Molecular Imaging of Secreted Frizzled Related Protein-2 Expression in Murine Angiosarcoma
PLOS ONE, 9(1).
MeSH headings : Animals; Antibodies / chemistry; Biomarkers, Tumor / chemistry; Biomarkers, Tumor / genetics; Biotinylation; Cell Line, Tumor; Contrast Media / pharmacokinetics; Gene Expression; Hemangiosarcoma / blood supply; Hemangiosarcoma / diagnosis; Hemangiosarcoma / diagnostic imaging; Hemangiosarcoma / pathology; Male; Membrane Proteins / chemistry; Membrane Proteins / genetics; Mice; Mice, Nude; Microbubbles; Molecular Imaging / methods; Neoplasm Transplantation; Skin Neoplasms / blood supply; Skin Neoplasms / diagnosis; Skin Neoplasms / diagnostic imaging; Skin Neoplasms / pathology; Streptavidin / chemistry; Ultrasonography
TL;DR:
Molecularly-targeted imaging of SFRP2 visualizes angiosarcoma vessels, but not normal vessels, and intensity increases with tumor size, which may provide a rapid, non-invasive method to monitor tumor regression during therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
A Comparative Evaluation of Ultrasound Molecular Imaging, Perfusion Imaging, and Volume Measurements in Evaluating Response to Therapy in Patient-Derived Xenografts
TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 12(4), 311–321.
author keywords: Ultrasound; 3-D; Microbubbles; Molecular imaging; Perfusion imaging; Response to therapy
MeSH headings : Animals; Azepines / therapeutic use; Contrast Media; Humans; Imaging, Three-Dimensional; Mice; Molecular Imaging / methods; Perfusion Imaging / methods; Pyrimidines / therapeutic use; Tumor Burden; Ultrasonics; Xenograft Model Antitumor Assays
TL;DR:
The data suggests that volumetric USMI and DCE-PI may be used to earlier classify and robustly characterize tumor response in two different types of patient-derived xenografts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
An In Vivo Evaluation of the Effect of Repeated Administration and Clearance of Targeted Contrast Agents on Molecular Imaging Signal Enhancement
THERANOSTICS, 3(2), 93–98.
author keywords: Microbubble; Contrast Agents; Molecular Imaging; Ultrasound; Targeted; cRGD
MeSH headings : Animals; Contrast Media / administration & dosage; Contrast Media / pharmacokinetics; Disease Models, Animal; Fibrosarcoma / diagnosis; Fibrosarcoma / diagnostic imaging; Imaging, Three-Dimensional; Molecular Imaging / methods; Rats; Rats, Inbred F344; Ultrasonography / methods
TL;DR:
Data suggest that multiple injections of targeted microbubbles do not block sufficient binding sites to bias molecular imaging data in serial studies, and repeated administration and clearance of targeted agents has on successive adhesion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Experimental Validation of Displacement Underestimation in ARFI Ultrasound
ULTRASONIC IMAGING, 35(3), 196–213.
author keywords: acoustic radiation force; ARFI; optical tracking; differential motion decorrelation; shearing artifact; displacement underestimation
MeSH headings : Acoustics; Elasticity; Elasticity Imaging Techniques / standards; Image Processing, Computer-Assisted / methods; Microspheres; Motion; Phantoms, Imaging; Reproducibility of Results; Ultrasonics / methods
TL;DR:
Optical tracking was utilized to experimentally measure the displacement underestimation achieved by acoustic tracking using a clinical ultrasound system and sets up a framework for future displacement tracking validation studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
In Vivo Demonstration of Cancer Molecular Imaging with Ultrasound Radiation Force and Buried-Ligand Microbubbles
MOLECULAR IMAGING, 12(6).
TL;DR:
The use of acoustically active buried-ligand microbubbles for ultrasound molecular imaging bridges the demand for low immunogenicity with the necessity of maintaining targeting efficacy and imaging conspicuity in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
TOWARD ULTRASOUND MOLECULAR IMAGING WITH PHASE-CHANGE CONTRAST AGENTS: AN IN VITRO PROOF OF PRINCIPLE
ULTRASOUND IN MEDICINE AND BIOLOGY, 39(5), 893–902.
author keywords: Perfluorocarbon droplet; Acoustic droplet vaporization; Molecular imaging; Contrast agent; Phase-change
MeSH headings : Cells, Cultured; Contrast Media / analysis; Contrast Media / chemical synthesis; Endothelial Cells / diagnostic imaging; Female; Fluorocarbons / chemical synthesis; Humans; Molecular Imaging / methods; Pilot Projects; Ultrasonography / methods
TL;DR:
A PCCA-based platform for molecular imaging using α(v)β(3)-targeted nanoscale PCCAs composed of low-boiling-point perfluorocarbons is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
AN IN VIVO VALIDATION OF THE APPLICATION OF ACOUSTIC RADIATION FORCE TO ENHANCE THE DIAGNOSTIC UTILITY OF MOLECULAR IMAGING USING 3-D ULTRASOUND
ULTRASOUND IN MEDICINE AND BIOLOGY, 38(4), 651–660.
author keywords: Microbubble; Molecular imaging; Targeted imaging; Radiation force
MeSH headings : Animals; Contrast Media / administration & dosage; Contrast Media / chemical synthesis; Elasticity Imaging Techniques / methods; Equipment Design; Fibrosarcoma / diagnostic imaging; Fibrosarcoma / pathology; Image Enhancement / methods; Imaging, Three-Dimensional / methods; Microbubbles; Molecular Imaging / methods; Rats, Inbred F344; Sensitivity and Specificity; Transducers
TL;DR:
This is the first noninvasive in vivo validation of ARF-enhanced MI with an unmodified clinical system and demonstrates that a 78% increase in image intensity from targeted microbubbles can be achieved when using ARF relative to the passive targeting studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 review
Phase-change nanoparticles using highly volatile perfluorocarbons: Toward a platform for extravascular ultrasound imaging
[Review of ]. Theranostics, 2(12), 1185–1198.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Improving sensitivity in ultrasound molecular imaging by tailoring contrast agent size distribution: In vivo studies
Molecular Imaging, 9(2), 87–95.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Optical tracking of acoustic radiation force impulse-induced dynamics in a tissue-mimicking phantom
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 126(5), 2733–2745.
MeSH headings : Artifacts; Elastic Tissue / diagnostic imaging; Elasticity; Gelatin; Microscopy, Acoustic / instrumentation; Microspheres; Models, Biological; Phantoms, Imaging; Transducers; Ultrasonics
TL;DR:
Optical tracking was utilized to investigate the acoustic radiation force impulse (ARFI)-induced response, generated by a 5-MHz piston transducer, in a translucent tissue-mimicking phantom, and provided high-frame-rate, two-dimensional tracking data that could prove useful in the investigation of complex ARFI-induced dynamics in controlled experimental settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
journal article
Assessment of molecular imaging of angiogenesis with three-dimensional ultrasonography
Streeter, J. E., Gessner, R. C., Tsuruta, J., Feingold, S., & Dayton, P. A. Molecular Imaging, 10(6), 460–468.
Source: NC State University Libraries
Added: August 6, 2018
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