Works (6)

Updated: July 5th, 2023 15:49

2014 journal article

Photophysical properties and electronic structure of retinylidene-chlorin-chalcones and analogues

Photochemical & Photobiological Sciences, 13(4), 634–650.

By: J. Springer, M. Taniguchi, M. Krayer, C. Ruzie, J. Diers, D. Niedzwiedzki, D. Bocian, J. Lindsey, D. Holten

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Photophysical Properties and Electronic Structure of Bacteriochlorin-Chalcones with Extended Near-Infrared Absorption

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 89(3), 586–604.

MeSH headings : Bacteriochlorophylls / chemistry; Chalcones / chemistry; Dimethyl Sulfoxide; Electrons; Kinetics; Molecular Mimicry; Porphyrins / chemistry; Quantum Theory; Solvents; Spectroscopy, Near-Infrared; Tetrapyrroles / chemistry; Thermodynamics; Toluene
TL;DR: Insight is provided into the fundamental properties of bacteriochlorins and designs for tuning the spectral and photophysical features of these near‐infrared‐absorbing tetrapyrrole chromophores are illustrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

In Vitro Photodynamic Therapy and Quantitative Structure-Activity Relationship Studies with Stable Synthetic Near-Infrared-Absorbing Bacteriochlorin Photosensitizers

JOURNAL OF MEDICINAL CHEMISTRY, 53(10), 4018–4027.

By: Y. Huang, P. Mroz*, T. Zhiyentayev, S. Sharma*, T. Balasubramanian, C. Ruzie*, M. Krayer*, D. Fan* ...

MeSH headings : Cell Death / drug effects; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Infrared Rays; Photochemotherapy; Photosensitizing Agents / chemistry; Photosensitizing Agents / metabolism; Photosensitizing Agents / pharmacology; Porphyrins / chemistry; Porphyrins / metabolism; Porphyrins / pharmacology; Quantitative Structure-Activity Relationship; Quantum Theory
TL;DR: Testing of 12 new stable synthetic bacteriochlorins for PDT activity described, which possess a variety of peripheral substituents and are very potent in killing cancer cells in vitro after illumination, gives them great potential as photosensitizers for treatment of cancer. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Stable Synthetic Cationic Bacteriochlorins as Selective Antimicrobial Photosensitizers

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(9), 3834–3841.

By: L. Huang*, Y. Huang*, P. Mroz*, G. Tegos*, T. Zhiyentayev*, S. Sharma*, Z. Lu*, T. Balasubramanian* ...

MeSH headings : Anti-Infective Agents / adverse effects; Anti-Infective Agents / chemical synthesis; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Candida albicans / drug effects; Candida albicans / radiation effects; Cell Survival / drug effects; Escherichia coli / drug effects; Escherichia coli / radiation effects; HeLa Cells; Humans; Light; Microscopy, Confocal; Molecular Structure; Photosensitizing Agents / adverse effects; Photosensitizing Agents / chemical synthesis; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Porphyrins / adverse effects; Porphyrins / chemical synthesis; Porphyrins / chemistry; Porphyrins / pharmacology; Staphylococcus aureus / drug effects; Staphylococcus aureus / radiation effects
TL;DR: Supporting photochemical and theoretical characterization studies indicate that the four bacteriochlorins have comparable photophysical features in homogeneous solution and the anticipated redox characteristics do not correlate with cell-killing ability, and these results support the interpretation that the disparate biological activities observed stem from cellular binding and localization effects rather than intrinsic electronic properties. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Stable synthetic bacteriochlorins overcome the resistance of melanoma to photodynamic therapy

FASEB JOURNAL, 24(9), 3160–3170.

By: P. Mroz*, Y. Huang*, A. Szokalska*, T. Zhiyentayev*, S. Janjua*, A. Nifli*, M. Sherwood*, C. Ruzie n ...

author keywords: multidrug resistance; melanosomes; electron microscopy
MeSH headings : Animals; Cell Line, Tumor; Male; Melanoma / drug therapy; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Molecular Structure; Photochemotherapy / methods; Porphyrins / chemical synthesis; Porphyrins / chemistry; Porphyrins / therapeutic use
TL;DR: The extent of melanin contribution to melanoma resistance to PDT was investigated in a set of melanoma cell lines that markedly differ in the levels of pigmentation;3 new bacteriochlorins successfully overcame the resistance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Refined syntheses of hydrodipyrrin precursors to chlorin and bacteriochlorin building blocks

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 13(10), 1098–1110.

By: M. Krayer n, T. Balasubramanian n, C. Ruzie n, M. Ptaszek n, D. Cramer n, M. Taniguchi n, J. Lindsey n

Contributors: M. Krayer n, T. Balasubramanian n, C. Ruzié n, M. Ptaszek n, D. Cramer n, M. Taniguchi n, J. Lindsey n

author keywords: chlorin; bacteriochlorin; bromination; dihydrodipyrrin; tetrahydrodipyrrin; McMurry cyclization; Michael addition
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

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