@article{merrill_ni_yoon_tirmenstein_narayanan_benavides_easton_creech_hu_mcfarland_et al._2002, title={Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically}, volume={68}, ISSN={["1096-6080"]}, DOI={10.1093/toxsci/68.1.93}, abstractNote={Although they are known to be effective antidiabetic agents, little is published about the toxic effects of carnitine palmitoyltransferase-1 (CPT-1) inhibitors, such as etomoxir (ET). These compounds inhibit mitochondrial fatty acid beta-oxidation by irreversibly binding to CPT-1 and preventing entry of long chain fatty acids into the mitochondrial matrix. Treatment of HepG2 cells with 1 mM etomoxir for 6 h caused significant modulations in the expression of several redox-related and cell cycle mRNAs as measured by microarray analysis. Upregulated mRNAs included heme oxygenase 1 (HO1), 8-oxoguanine DNA glycosylase 1 (OGG1), glutathione reductase (GSR), cyclin-dependent kinase inhibitor 1A (CDKN1 [p21(waf1)]) and Mn+ superoxide dismutase precursor (SOD2); while cytochrome P450 1A1 (CYP1A1) and heat shock 70kD protein 1 (HSPA1A) were downregulated. Real time quantitative PCR (RT-PCR) confirmed the significant changes in 4 of 4 mRNAs assayed (CYP1A1, HO1, GSR, CDKN1), and identified 3 additional mRNA changes; 2 redox-related genes, gamma-glutamate-cysteine ligase modifier subunit (GCLM) and thioredoxin reductase (TXNRD1) and 1 DNA replication gene, topoisomerase IIalpha (TOP2A). Temporal changes in selected mRNA levels were examined by RT-PCR over 11 time points from 15 min to 24 h postdosing. CYP1A1 exhibited a 38-fold decrease by 4 h, which rebounded to a 39-fold increase by 20 h. GCLM and TXNRD1 exhibited 13- and 9-fold increases, respectively at 24 h. Etomoxir-induced oxidative stress and impaired mitochondrial energy metabolism were confirmed by a significant decrease in reduced glutathione (GSH), reduced/oxidized glutathione ratio (GSH/GSSG), mitochondrial membrane potential (MMP), and ATP levels, and by concurrent increase in oxidized glutathione (GSSG) and superoxide generation. This is the first report of oxidative stress caused by etomoxir.}, number={1}, journal={TOXICOLOGICAL SCIENCES}, author={Merrill, CL and Ni, H and Yoon, LW and Tirmenstein, MA and Narayanan, P and Benavides, GR and Easton, MJ and Creech, DR and Hu, CX and McFarland, DC and et al.}, year={2002}, month={Jul}, pages={93–101} }
 @article{tocidlowski_merrill_loomis_wright_2001, title={Teratoma in desert grassland whiptail lizards (Cnemidophorus uniparens)}, volume={32}, number={2}, journal={Journal of Zoo and Wildlife Medicine}, author={Tocidlowski, M. E. and Merrill, C. L. and Loomis, M. R. and Wright, J. F.}, year={2001}, pages={257–259} }
 @article{marcellin-little_deyoung_thrall_merrill_1999, title={Osteosarcoma at the site of bone infarction associated with total hip arthroplasty in a dog}, volume={28}, ISSN={["0161-3499"]}, DOI={10.1053/jvet.1999.0054}, abstractNote={Objective— To report the occurrence of medullary bone infarction in both femoral canals after bilateral total hip arthroplasty (THA) and the subsequent unilateral development of an osteosarcoma at the site of bone infarction.}, number={1}, journal={VETERINARY SURGERY}, author={Marcellin-Little, DJ and DeYoung, DJ and Thrall, DE and Merrill, CL}, year={1999}, pages={54–60} }
 @article{powers_merrill_degernes_miller_latimer_barnes_1998, title={Axillary cystadenocarcinoma in a Moluccan cockatoo (Cacatua moluccensis)}, volume={42}, ISSN={["0005-2086"]}, DOI={10.2307/1592495}, abstractNote={An adult Moluccan cockatoo (Cacatua moluccensis) was diagnosed with a cystadenocarcinoma in the right axillary region that was treated symptomatically with surgical debulking and periodic drainage. The bird eventually died and a necropsy was performed. The neoplasm extended through the humerus, and small neoplastic foci were seen within the ipsilateral lung parenchyma. Rare groupings of microvilli were observed lining intercellular canalicular lumens on electron microscopy within the axillary tumor. These findings suggest a respiratory neoplasm, although the tissue of origin remained undetermined.}, number={2}, journal={AVIAN DISEASES}, author={Powers, LV and Merrill, CL and Degernes, LA and Miller, R and Latimer, KS and Barnes, HJ}, year={1998}, pages={408–412} }