@article{s. d'costa_yoon_kim_motsinger-reif_williams_kim_2012, title={Morphologic and Molecular Analysis of 39 Spontaneous Feline Pulmonary Carcinomas}, volume={49}, ISSN={["1544-2217"]}, url={http://dx.doi.org/10.1177/0300985811419529}, DOI={10.1177/0300985811419529}, abstractNote={The present study was performed to determine the morphologic change and selected molecular features of spontaneous lung tumors in cats examined at the North Carolina State University Veterinary Teaching Hospital. Thirty-nine primary lung carcinomas represented 0.69% of all feline cases admitted to the hospital. Most lung tumors were observed in aged cats ( P < .0001), and no sex predilection was found ( P < .4241). Persian cats with pulmonary carcinoma were overrepresented in the data set, at least 4 times more frequently than other breeds. The histologic tumor types included adenocarcinoma (64.1%), bronchioloalveolar carcinoma (20.5%), and adenosquamous carcinoma (15.4%). Metastasis was observed in about 80% of 39 cases, with decreasing order of intrapulmonary metastasis, intrathoracic carcinomatosis, regional lymph nodes, and distant organs, including digits. The size of the largest tumor mass was significantly associated with metastatic potential ( P < .001). Based on immunohistochemistry, more than 80% (20 of 24) of feline lung tumors were positively labeled with either surfactant protein A or thyroid transcription factor 1. Epidermal growth factor receptor mutant and p53 proteins were detected in approximately 20% (5 of 24) and 25% (6 of 24) of the feline lung tumor cases, respectively. Limited sequencing analysis of K-ras and p53 genes in 3 selected normal and neoplastic lung tissues did not reveal any alteration. Results indicate that primary lung carcinomas are rare but aggressive tumors in cats, thereby warranting further studies on molecular carcinogenesis.}, number={6}, journal={VETERINARY PATHOLOGY}, author={S. D'Costa and Yoon, B. -I. and Kim, D. -Y. and Motsinger-Reif, A. A. and Williams, M. and Kim, Y.}, year={2012}, month={Nov}, pages={971–978} }
 @article{kai_d'costa_yoon_brody_sills_kim_2010, title={Characterization of side population cells in human malignant mesothelioma cell lines}, volume={70}, ISSN={["1872-8332"]}, DOI={10.1016/j.lungcan.2010.04.020}, abstractNote={Side population (SP) assay composed of Hoechst 33342 staining and subsequent flow cytometric analysis has been widely utilized for characterizing putative cancer stem cells (CSCs) in various human malignancies. The present study was designed to evaluate the SP assay as a research tool for mesothelial CSCs. A distinct fraction of SP cells was identified in various human malignant mesothelioma (HMM) cell lines, ranging from 0.05 to 1.32%. The sorted mesothelial SP cells exhibited enhanced proliferation potentials and higher expression of stem-cell genes, compared to non-SP (NSP) cells. Cisplatin treatment increased percentage of SP cells in the HMM cell lines. However, tumorigenic potential of SP cells in immunodeficient mice was similar to that of the NSP cells. These data indicated that SP assay may not be appropriate for enriching putative CSCs in HMM cell lines, and thus warrants the development of a novel tool for mesothelial CSC study.}, number={2}, journal={LUNG CANCER}, author={Kai, Kiyonori and D'Costa, Susan and Yoon, Byung-Il and Brody, Arnold R. and Sills, Robert C. and Kim, Yongbaek}, year={2010}, month={Nov}, pages={146–151} }
 @article{yoon_kim_yi_kang_jang_joo_kim_law_kim_2010, title={Expression of thioredoxin during progression of hamster and human cholangiocarcinoma}, volume={101}, ISSN={["1349-7006"]}, DOI={10.1111/j.1349-7006.2009.01353.x}, abstractNote={Thioredoxin (Trx) is a multifunctional redox protein that has growth‐promoting and anti‐apoptotic effects on cells and protects cells from endogenous and exogenous free radicals. Recently, altered expression of Trx has been reported in various cancers. In the present study, we investigated altered expression of Trx at the precancerous and carcinogenic phases during cholangiocarcinogenesis in a hamster cholangiocarcinoma (ChC) model, using semiquantitative immunohistochemical and Western blot analyses. Moreover, to determine if the results correlated well with those in human ChCs, we carried out a comparative immunohistochemical study for Trx in tissue‐arrayed human ChCs with different grades of tumor cell differentiation. Trx was found highly expressed in the cytoplasm of dysplastic bile ducts with highly abnormal growth patterns and ChCs irrespective of tumor type or tumor cell differentiation. Overexpression of Trx at the precancerous and carcinogenic phases was further supported by significant elevation of Trx protein in Western blotting. The results from the hamster ChCs were in good agreement with those from human ChCs. Our results strongly suggested that the redox regulatory function of Trx plays an important role in bile duct cell transformation and tumor progression during cholangiocarcinogenesis. (Cancer Sci 2009)}, number={1}, journal={CANCER SCIENCE}, author={Yoon, Byung-Il and Kim, Yeong-Hun and Yi, Jung-Yeon and Kang, Min-Soo and Jang, Ja-June and Joo, Kyoung-Hwan and Kim, Yongbaek and Law, J. McHugh and Kim, Dae-Yong}, year={2010}, month={Jan}, pages={281–288} }
 @article{yi_kim_kim_hahn_jeong_choi_woo_kim_han_yoon_2010, title={Prevalence of Hepatic Parasites in Korean Wild Rats (Rattus norvegicus) and Their Association With Pulmonary Arteriolar Medial Hypertrophy}, volume={47}, ISSN={["1544-2217"]}, DOI={10.1177/0300985809359306}, abstractNote={ C hepatica, an important zoonotic parasite, and C fasciolaris are common parasites in rodents. In rodent livers, C hepatica causes sequential morphologic changes that are designated as early, intermediate, or late phase, and C fasciolaris forms cysts surrounded by fibroplasia and granulomatous inflammation. The present study describes the prevalence of these parasites and associated liver and lung lesions in wild rats ( Rattus norvegicus) living around pig farms in South Korea. Selected parenchymal organs, including liver and lung, of 89 wild rats were examined. Of 89 rats, 28 (31.5%) were infected with either C hepatica or C fasciolaris or with both parasites. Severe medial hypertrophy of small arterioles was observed in the lungs of 11 of the 28 parasite-infected rats ( P < .01). The pulmonary arteriolar hypertrophy in the rats infected with C hepatica was strongly associated with early and/or intermediate phases (88.8%) of morphologic change in the livers ( P < .01). As such, this report is the first to suggest a significant association between parasite-induced hepatitis and pulmonary arteriolar hypertrophy in rodents. Further studies are warranted for the use of C hepatica–infected rats as an animal model to explore the underlying mechanisms of portopulmonary hypertension in humans. }, number={2}, journal={VETERINARY PATHOLOGY}, author={Yi, J. -Y. and Kim, Y. -H. and Kim, H. -C. and Hahn, T. -W. and Jeong, H. and Choi, C. -U. and Woo, G. -H. and Kim, Y. -B. and Han, J. -H. and Yoon, B. -I.}, year={2010}, month={Mar}, pages={292–297} }