Robert R. Maronpot

author keywords: liver; lung; mammary gland; rodent; microarray gene expression analysis; genomics; cancer; review; gene expression profiling; neoplasia

MeSH headings : Animals; Humans; Microarray Analysis; Neoplasms / etiology; Neoplasms / genetics; Neoplasms / pathology

TL;DR: It is clear that pathologists and toxicologists, in collaboration with molecular biologists, bioinformatists, and other scientists are making great strides in the design, analysis, and interpretation of microarray data for cancer studies. (via Semantic Scholar)

author keywords: liver neoplasia; mice; hemangiosarcoma; cell proliferation; H-ras; hepatitis

MeSH headings : Animals; Carcinogenicity Tests; Cell Cycle / physiology; Female; Genes, ras; Helicobacter; Helicobacter Infections / complications; Hepatitis / microbiology; Liver Neoplasms, Experimental / genetics; Liver Neoplasms, Experimental / microbiology; Male; Mice; Mice, Inbred Strains; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Rats; Rats, Inbred F344

TL;DR: Data support the hypothesis that the increased incidence of liver neoplasms is associated with H. hepaticus and that hepatitis may be important in the pathogenesis and interpretation of carcinogenic effects in the liver of B6C3F1 mice may be confounded if there is H. liveraticus-associaled hepatitis. (via Semantic Scholar)

TL;DR: The results suggest that mirex may have highly specific effects on the proliferation of initiated cells and support the existence of a unique mirez mechanism and/or distinct population of mireX‐promotable mutant Ha‐ras epidermal cells. (via Semantic Scholar)

MeSH headings : Acetates / administration & dosage; Acetates / toxicity; Administration, Oral; Animals; Cells, Cultured; Corpus Luteum / drug effects; Corpus Luteum / pathology; Estradiol / biosynthesis; Estradiol / blood; Estrus / drug effects; Ethylene Glycols / administration & dosage; Ethylene Glycols / toxicity; Female; Follicle Stimulating Hormone / metabolism; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / toxicity; Luteinizing Hormone / drug effects; Luteinizing Hormone / metabolism; Progesterone / biosynthesis; Progesterone / blood; Rats; Rats, Sprague-Dawley; Solvents / administration & dosage; Solvents / toxicity; Vagina / cytology; Vagina / drug effects

TL;DR: It is established that the ovarian luteal cell is a target of EGME and MAA in vivo and in vitro and that the effect on lutesal cell progesterone production is likely independent of LH-stimulated cAMP pathways. (via Semantic Scholar)