@article{smith_nanda_spears_piper_ribeiro_quiles_briggs_thomas_thomas_brown_et al._2012, title={Testing of Novel Dengue Virus 2 Vaccines in African Green Monkeys: Safety, Immunogenicity, and Efficacy}, DOI={10.4269/ajtmh.2012.12-0004}, abstractNote={The immunogenicity and safety of three novel host-range vaccines containing deletions in the transmembrane domain of dengue virus serotype 2 (DV2) E glycoprotein were evaluated in African green monkeys. The shorter transmembrane domains are capable of functionally spanning an insect but not a mammalian cell membrane, resulting in production of viral mutants that have reduced infectivity in mammalian hosts but efficient growth in insect cells. Groups of four monkeys received one dose each of test vaccine candidate with no booster immunization. After immunization, levels of viremia produced by each vaccine were determined by infectious center assay. Vaccine recipient immune response to wild-type DV2 challenge was measured on Day 57 by enzyme-linked immunosorbent assay and plaque reduction neutralization test. Two vaccines, DV2ΔGVII and DV2G460P, generated neutralizing antibody in the range of 700–900 50% plaque reduction neutralization test units. All three vaccine strains decreased the length of viremia by at least two days. No safety concerns were identified.}, number={4}, journal={American Journal of Tropical Medicine and Hygiene}, author={Smith, Katherine M. and Nanda, Kavita and Spears, Carla J. and Piper, Amanda and Ribeiro, Mariana and Quiles, Michelle and Briggs, Caitlin M. and Thomas, Gwynneth S. and Thomas, Malcolm E. and Brown, Dennis T. and et al.}, year={2012}, month={Sep} } @article{ribeiro_hurd_wu_martino_jones_brighton_boucher_o'neal_2009, title={Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia}, volume={4}, number={6}, journal={PLoS One}, author={Ribeiro, C. M. P. and Hurd, H. and Wu, Y. C. and Martino, M. E. B. and Jones, L. and Brighton, B. and Boucher, R. C. and O'Neal, W. K.}, year={2009} }