Akinobu Kajikawa

Works (5)

Updated: August 3rd, 2023 21:15

2011 journal article

Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector

CLINICAL AND VACCINE IMMUNOLOGY, 18(11), 1834–1844.

By: L. Stoeker n, S. Nordone n, S. Gunderson n, L. Zhang  n, A. Kajikawa n, A. LaVoy n, M. Miller n, T. Klaenhammer n, G. Dean n

MeSH headings : Adjuvants, Immunologic / genetics; Administration, Oral; Animals; B-Lymphocytes / immunology; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Blood / immunology; Colon / immunology; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers / administration & dosage; Female; Flagellin / genetics; Genetic Vectors; Humans; Intestinal Mucosa / immunology; Lactobacillus / genetics; Lactobacillus / immunology; Mice; Mice, Inbred BALB C; Plasmids; Toll-Like Receptor 5 / immunology
TL;DR: In vivo studies established that treatment with L. gasseri led to a diversification of B-cell populations in the lamina propria of the murine colon and a significant decrease in the percentage of FoxP3+ colonic lymphocytes, and in vivo data clarify the interaction of L. Gasseri with the host immune system and support further investigation of the in vivo immunogenicity of the vector. (via Semantic Scholar)
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Added: August 6, 2018

2011 journal article

Dissimilar Properties of Two Recombinant Lactobacillus acidophilus Strains Displaying Salmonella FliC with Different Anchoring Motifs

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77(18), 6587–6596.

By: A. Kajikawa n, S. Nordone, L. Zhang*, L. Stoeker*, A. LaVoy*, T. Klaenhammer n, G. Dean*

MeSH headings : Acids / metabolism; Antigens, Bacterial / genetics; Antigens, Bacterial / metabolism; Cells, Cultured; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers; Drug Stability; Flagellin / genetics; Flagellin / metabolism; Genetic Vectors; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Peptide Hydrolases / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Salmonella Vaccines / genetics; Salmonella Vaccines / immunology; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology
TL;DR: Two recombinant L. acidophilus derivatives displaying Salmonella flagellin were constructed using different anchor motifs, and the surface-associated antigen was highly sensitive to simulated gastric and small intestinal juices. (via Semantic Scholar)
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Added: August 6, 2018

2010 journal article

Adjuvant Effects for Oral Immunization Provided by Recombinant Lactobacillus casei Secreting Biologically Active Murine Interleukin-1 beta

CLINICAL AND VACCINE IMMUNOLOGY, 17(1), 43–48.

By: A. Kajikawa*, K. Masuda  n, M. Katoh n & S. Igimi n

MeSH headings : Adjuvants, Immunologic / genetics; Adjuvants, Immunologic / metabolism; Animals; Antibodies, Bacterial / blood; Female; Ileum / immunology; Immunization / methods; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Interleukin-6 / metabolism; Lacticaseibacillus casei / genetics; Lacticaseibacillus casei / immunology; Mice; Mice, Inbred BALB C; Peyer's Patches / immunology; Salmonella Vaccines / administration & dosage; Salmonella Vaccines / genetics; Salmonella Vaccines / immunology; Salmonella enteritidis / immunology
TL;DR: It was demonstrated that recombinant L. casei secreting bioactive murine IL-1β provided adjuvant effects for intragastric immunization. (via Semantic Scholar)
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Added: August 6, 2018

2010 journal article

Development of a highly efficient protein-secreting system in recombinant Lactobacillus casei

Journal of Microbiology and Biotechnology, 20(2), 375–382.

By: A. Kajikawa, E. Ichikawa & S. Igimi

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Innate and acquired immune responses induced by recombinant Lactobacillus casei displaying flagellin-fusion antigen on the cell-surface

VACCINE, 28(19), 3409–3415.

By: A. Kajikawa n & S. Igimi*

author keywords: Lactobacillus; Flagellin; TLR5
MeSH headings : Animals; Antigens, Bacterial / genetics; Antigens, Bacterial / immunology; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Caco-2 Cells; Female; Flagellin / genetics; Flagellin / immunology; Genetic Vectors; Humans; Lacticaseibacillus casei / genetics; Mice; Mice, Inbred C3H; Salmonella Vaccines / genetics; Salmonella Vaccines / immunology; Th1 Cells / immunology; Th2 Cells / immunology
TL;DR: The results showed that the outside epitope of the heterologous antigen was recognized more easily by the immune system than the inside epitope, although some of the responses were mixed. (via Semantic Scholar)
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