@article{briley_williams_freire_griffith_lascelles_2014, title={Feasibility and repeatability of cold and mechanical quantitative sensory testing in normal dogs}, volume={199}, ISSN={["1532-2971"]}, url={https://dx.doi.org/10.1016/j.tvjl.2013.10.025}, DOI={10.1016/j.tvjl.2013.10.025}, abstractNote={Feasibility and inter-session repeatability of cold and mechanical quantitative sensory testing (QST) were assessed in 24 normal dogs. Cold thermal latencies were evaluated using a thermal probe (0°C) applied to three pelvic limb sites. Mechanical thresholds were measured using an electronic von Frey anesthesiometer (EVF) and a blunt-probed pressure algometer (PA) applied to the dorsal aspect of the metatarsus. All QST trials were performed with dogs in lateral recumbency. Collection of cold QST data was easy (feasible) in 19/24 (79%) dogs. However, only 18.4%, 18.9% and 13.2% of cold QST trials elicited a response at the medial tibia, third digital pad and plantar metatarsal regions, respectively. Collection of mechanical QST data was easy (feasible) in 20/24 (83%) dogs for both EVF and PA. At consecutive sampling times, approximately 2 weeks apart, the average EVF sensory thresholds were 414 ± 186 g and 379 ± 166 g, respectively, and the average PA sensory thresholds were 1089 ± 414 g and 1028 ± 331 g, respectively. There was no significant difference in inter-session or inter-limb threshold values for either mechanical QST device. The cold QST protocol in this study was achievable, but did not provide consistently quantifiable results. Both mechanical QST devices tested provided repeatable, reliable sensory threshold measurements in normal, client-owned dogs. These findings contribute to the validation of the EVF and PA as tools to obtain repeated QST data over time in dogs to assess somatosensory processing changes.}, number={2}, journal={VETERINARY JOURNAL}, author={Briley, Jessica D. and Williams, Morika D. and Freire, Mila and Griffith, Emily H. and Lascelles, B. Duncan X.}, year={2014}, month={Feb}, pages={245–250} }
 @article{freire_meuten_lascelles_2014, title={Pathology of Articular Cartilage and Synovial Membrane From Elbow Joints With and Without Degenerative Joint Disease in Domestic Cats}, volume={51}, ISSN={["1544-2217"]}, url={https://dx.doi.org/10.1177/0300985813516648}, DOI={10.1177/0300985813516648}, abstractNote={ The elbow joint is one of the feline appendicular joints most commonly and severely affected by degenerative joint disease. The macroscopic and histopathological lesions of the elbow joints of 30 adult cats were evaluated immediately after euthanasia. Macroscopic evidence of degenerative joint disease was found in 22 of 30 cats (39 elbow joints) (73.33% cats; 65% elbow joints), and macroscopic cartilage erosion ranged from mild fibrillation to complete ulceration of the hyaline cartilage with exposure of the subchondral bone. Distribution of the lesions in the cartilage indicated the presence of medial compartment joint disease (most severe lesions located in the medial coronoid process of the ulna and medial humeral epicondyle). Synovitis scores were mild overall and correlated only weakly with macroscopic cartilage damage. Intra-articular osteochondral fragments either free or attached to the synovium were found in 10 joints. Macroscopic or histologic evidence of a fragmented coronoid process was not found even in those cases with intra-articular osteochondral fragments. Lesions observed in these animals are most consistent with synovial osteochondromatosis secondary to degenerative joint disease. The pathogenesis for the medial compartmentalization of these lesions has not been established, but a fragmented medial coronoid process or osteochondritis dissecans does not appear to play a role. }, number={5}, journal={VETERINARY PATHOLOGY}, publisher={SAGE Publications Sage CA: Los Angeles, CA}, author={Freire, M. and Meuten, D. and Lascelles, D.}, year={2014}, month={Sep}, pages={968–978} }
 @article{charlton_benito_simpson_freire_lascelles_2013, title={Evaluation of the clinical use of tepoxalin and meloxicam in cats}, volume={15}, ISSN={["1532-2750"]}, url={https://dx.doi.org/10.1177/1098612x12473994}, DOI={10.1177/1098612x12473994}, abstractNote={ Medical records where tepoxalin (Zubrin) or meloxicam (Metacam) were prescribed in cats were reviewed and data extracted. Comparisons were performed for exploring changes between pre- and post-non-steroidal anti-inflammatory drug course laboratory tests. Seventy-nine medical records fit the inclusion criteria (n = 57 and n = 22, tepoxalin and meloxicam, respectively). The median dosages administered were 13 and 0.029 mg/kg/day (tepoxalin and meloxicam, respectively). Median prescription durations were 11 (2–919) and 93 (4–1814) days for tepoxalin and meloxicam, respectively. Suspected adverse events were reported for tepoxalin (9%, 5/57 cats) and meloxicam (18%, 4/22 cats) a median of 774 and 448 days, respectively, after the prescription started. For cats prescribed meloxicam, there were several statistically significant changes for serum biochemistry and hematology parameters, but median values were within normal limits. These valuable clinical data suggest that tepoxalin and meloxicam are well tolerated in the clinical setting at the doses prescribed in this study. }, number={8}, journal={JOURNAL OF FELINE MEDICINE AND SURGERY}, author={Charlton, Anna N. and Benito, Javier and Simpson, Wendy and Freire, Mila and Lascelles, B. Duncan X.}, year={2013}, month={Aug}, pages={678–690} }
 @article{freire_robertson_bondell_brown_hash_pease_lascelles_2011, title={RADIOGRAPHIC EVALUATION OF FELINE APPENDICULAR DEGENERATIVE JOINT DISEASE VS. MACROSCOPIC APPEARANCE OF ARTICULAR CARTILAGE}, volume={52}, ISSN={["1058-8183"]}, url={https://dx.doi.org/10.1111/j.1740-8261.2011.01803.x}, DOI={10.1111/j.1740-8261.2011.01803.x}, abstractNote={Degenerative joint disease (DJD) is common in domesticated cats. Our purpose was to describe how radiographic findings thought to indicate feline DJD relate to macroscopic cartilage degeneration in appendicular joints. Thirty adult cats euthanized for reasons unrelated to this study were evaluated. Orthogonal digital radiographs of the elbow, tarsus, stifle, and coxofemoral joints were evaluated for the presence of DJD. The same joints were dissected for visual inspection of changes indicative of DJD and macroscopic cartilage damage was graded using a Total Cartilage Damage Score. When considering all joints, there was statistically significant fair correlation between cartilage damage and the presence of osteophytes and joint‐associated mineralizations, and the subjective radiographic DJD score. Most correlations were statistically significant when looking at the different joints individually, but only the correlation between the presence of osteophytes and the subjective radiographic DJD score with the presence of cartilage damage in the elbow and coxofemoral joints had a value above 0.4 (moderate correlation). The joints most likely to have cartilage damage without radiographic evidence of DJD are the stifle (71% of radiographically normal joints) followed by the coxofemoral joint (57%), elbow (57%), and tarsal joint (46%). Our data support radiographic findings not relating well to cartilage degeneration, and that other modalities should be evaluated to aid in making a diagnosis of feline DJD.}, number={3}, journal={VETERINARY RADIOLOGY & ULTRASOUND}, author={Freire, Mila and Robertson, Ian and Bondell, Howard D. and Brown, James and Hash, Jon and Pease, Anthony P. and Lascelles, B. Duncan X.}, year={2011}, pages={239–247} }
 @article{lascelles_freire_roe_depuy_smith_marcellin-little_2010, title={Evaluation of Functional Outcome After BFX (R) Total Hip Replacement Using a Pressure Sensitive Walkway}, volume={39}, ISSN={["0161-3499"]}, url={https://dx.doi.org/10.1111/j.1532-950X.2009.00607.x}, DOI={10.1111/j.1532-950X.2009.00607.x}, abstractNote={OBJECTIVE
To evaluate stance phase limb use after cementless (BFX) total hip replacement (THR) in dogs and to relate postoperative radiographic variables to static bodyweight distribution after surgery.


STUDY DESIGN
Prospective clinical study.


ANIMALS
Dogs (n=35) that had THR.


METHODS
THR was performed using the BFX THR technique. Postoperative pain management regimens were similar for all dogs. Standing bodyweight distribution (%BW(distrib)) was measured using a pressure sensitive walkway and radiographs made before surgery and at 3, 6, and 12 months after surgery. Repeated measures models (with backwards-stepping to obtain the final model) were used for statistical analysis.


RESULTS
Temporally, %BW(distrib) to the operated limb increased (P<.0001; normal by 3 months) and decreased to the unoperated limb (P=.0001) and also increased to the pelvic limbs and decreased to the thoracic limbs. %BW(distrib) to the unoperated limb was significantly less than the operated limb at 3, 6, and 12 months after surgery. Postoperative canal fill and femur flare were significantly negatively correlated with change in %BW(distrib) (estimate=-0.24, P=.0413).


CONCLUSION
BFX THR results in normal %BW(distrib) to the operated limb by 3 months after surgery. A greater fill of the proximal femur may be associated with a suboptimal outcome.


CLINICAL RELEVANCE
BFX THR normalizes standing bodyweight distribution dogs with hip osteoarthritis. Objective evaluation of THR outcome and radiographic features may reveal factors that could be improved through changes in prosthesis design or surgical technique.}, number={1}, journal={VETERINARY SURGERY}, publisher={Blackwell Publishing Inc Malden, USA}, author={Lascelles, B. Duncan X. and Freire, Mila and Roe, Simon C. and DePuy, Venita and Smith, Eric and Marcellin-Little, Denis J.}, year={2010}, month={Jan}, pages={71–77} }