@article{henriquez_house_miller_snow_fisher_ren_schladweiler_ledbetter_wright_kodavanti_2017, title={Adrenal-derived stress hormones modulate ozone-induced lung injury and inflammation}, volume={329}, ISSN={["1096-0333"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85020944922&partnerID=MN8TOARS}, DOI={10.1016/j.taap.2017.06.009}, abstractNote={Ozone-induced systemic effects are modulated through activation of the neuro-hormonal stress response pathway. Adrenal demedullation (DEMED) or bilateral total adrenalectomy (ADREX) inhibits systemic and pulmonary effects of acute ozone exposure. To understand the influence of adrenal-derived stress hormones in mediating ozone-induced lung injury/inflammation, we assessed global gene expression (mRNA sequencing) and selected proteins in lung tissues from male Wistar-Kyoto rats that underwent DEMED, ADREX, or sham surgery (SHAM) prior to their exposure to air or ozone (1 ppm), 4 h/day for 1 or 2 days. Ozone exposure significantly changed the expression of over 2300 genes in lungs of SHAM rats, and these changes were markedly reduced in DEMED and ADREX rats. SHAM surgery but not DEMED or ADREX resulted in activation of multiple ozone-responsive pathways, including glucocorticoid, acute phase response, NRF2, and PI3K-AKT. Predicted targets from sequencing data showed a similarity between transcriptional changes induced by ozone and adrenergic and steroidal modulation of effects in SHAM but not ADREX rats. Ozone-induced increases in lung Il6 in SHAM rats coincided with neutrophilic inflammation, but were diminished in DEMED and ADREX rats. Although ozone exposure in SHAM rats did not significantly alter mRNA expression of Ifnγ and Il-4, the IL-4 protein and ratio of IL-4 to IFNγ (IL-4/IFNγ) proteins increased suggesting a tendency for a Th2 response. This did not occur in ADREX and DEMED rats. We demonstrate that ozone-induced lung injury and neutrophilic inflammation require the presence of circulating epinephrine and corticosterone, which transcriptionally regulates signaling mechanisms involved in this response.}, journal={TOXICOLOGY AND APPLIED PHARMACOLOGY}, author={Henriquez, Andres and House, John and Miller, Desinia B. and Snow, Samantha J. and Fisher, Anna and Ren, Hongzu and Schladweiler, Mette C. and Ledbetter, Allen D. and Wright, Fred and Kodavanti, Urmila P.}, year={2017}, month={Aug}, pages={249–258} }
 @article{barrett_sobsey_house_white_2001, title={Microbial indicator removal in onsite constructed wetlands for wastewater treatment in the southeastern US}, volume={44}, number={11-12}, journal={Water Science and Technology}, author={Barrett, E. C. and Sobsey, M. D. and House, C. H. and White, K. D.}, year={2001}, pages={177–182} }
 @book{liehr_kozub_rash_sloop_doll_rubin_house_hawes_burks_2000, title={Constructed wetlands treatment of high nitrogen landfill leachate}, ISBN={1893664082}, publisher={Alexandria, VA : Water Environment Research Foundation}, author={Liehr, S. K. and Kozub, D. D. and Rash, J. K. and Sloop, G. M. and Doll, B. and Rubin, A. R. and House, C. H. and Hawes, S. and Burks, D.}, year={2000} }
 @article{house_bergmann_stomp_frederick_1999, title={Combining constructed wetlands and aquatic and soil filters for reclamation and reuse of water}, volume={12}, ISSN={["0925-8574"]}, DOI={10.1016/S0925-8574(98)00052-4}, abstractNote={Reclamation and reuse of water and nutrients at their source provide the opportunity to use simple, less costly technologies and lessens potentials for catastrophic effects due to centralized treatment system failures. The combination of multiple treatment environments within constructed wetlands can provide water quality suitable for reuse. A current project in rural Chatham County, NC, uses simple, aesthetically pleasing treatment components constructed both outdoors and indoors to reclaim domestic sewage for toilet flushing, landscape irrigation and aesthetic water features. A courtyard containing constructed wetlands and a solarium with modular soil filter components and aquatic chambers are designed to treat sewage from within a small business facility and to provide recreational space for its 60 employees. The combination of vertical flow and horizontal flow constructed wetlands with fill and draw controls provides the necessary environments for nitrification–denitrification, removal of organic materials and phosphorus adsorption reactions. The system is designed to treat and reuse 4500 l day−1 (1200 gal day−1) of domestic sewage from the business. Some of the plants used are selectively bred or genetically engineered to maximize their water reclamation potential. Utilization of simple treatment and reuse technology has permitted the business owner to renovate an abandoned and deteriorating school building into a home for two thriving and internationally based businesses and to protect the water quality of a nearby reservoir.}, number={1-2}, journal={ECOLOGICAL ENGINEERING}, author={House, CH and Bergmann, BA and Stomp, AM and Frederick, DJ}, year={1999}, month={Jan}, pages={27–38} }
 @book{house_1998, title={Evaluation of domestic wastewater treatment by constructed wetlands}, number={1998 Apr. 1}, journal={Report (Water Resources Research Institute of the University of North Carolina)}, institution={Raleigh, NC: University of North Carolina Water Resources Research Institute}, author={House, H.}, year={1998} }
 @inproceedings{spooner_house_hoover_rubin_silverthorne_steinbeck_harris_uebler_martin_1998, title={Performance evaluation of innovative and alternative on-site wastewater treatment systems in Craven County, NC}, booktitle={On-site wastewater treatment: Proceedings of the eighth national symposium on individual and small community sewage systems, March 8-10, 1998, Orlando, Florida}, publisher={St. Joseph, Mich.: American Society of Agricultural Engineers}, author={Spooner, J. and House, C. H. and Hoover, M. T. and Rubin, A. R. and Silverthorne, R. and Steinbeck, S. J. and Harris, V. and Uebler, R. L. and Martin, B.}, year={1998}, pages={458–469} }
 @article{house_broome_hoover_1994, title={Treatment of nitrogen and phosphorus by a constructed upland-wetland wastewater treatment system}, volume={29}, number={4}, journal={Water Science and Technology}, author={House, C. H. and Broome, S. W. and Hoover, M. T.}, year={1994}, pages={177} }