Works (1)

Updated: July 5th, 2023 15:49

2010 journal article

Vesicle-associated Membrane Protein (VAMP) Cleavage by a New Metalloprotease from the Brazilian Scorpion Tityus serrulatus


By: P. Fletcher*, M. Fletcher, K. Weninger n, T. Anderson n & B. Martin*

MeSH headings : Amino Acid Sequence; Animals; Guinea Pigs; Immunohistochemistry; Metalloproteases / metabolism; Metalloproteases / ultrastructure; Models, Molecular; Molecular Sequence Data; Pancreas, Exocrine / anatomy & histology; Pancreas, Exocrine / metabolism; Protein Conformation; Protein Isoforms / metabolism; R-SNARE Proteins / metabolism; R-SNARE Proteins / ultrastructure; SNARE Proteins / metabolism; Scorpion Venoms / enzymology; Scorpions / enzymology; Secretory Vesicles / chemistry; Secretory Vesicles / ultrastructure
TL;DR: Evidence is presented that venom from the Brazilian scorpion Tityus serrulatus and a purified fraction selectively cleave essential SNARE proteins within exocrine pancreatic tissue and the unique cleavages of VAMP2 and VAMP8 may be linked to pancreatitis that develops following scorpion envenomation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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