Amanda D. Piper

Works (8)

Updated: August 8th, 2023 21:15

2016 journal article

The role of the vacuolar ATPase in alphavirus replication.

Molecular Biology of the Cell, 27.

By: R. Schuchman, R. Vancini, A. Piper, D. Breuer, M. Ribeiro, D. Farreira, J. Magliocca, V. Emmerich, R. Hernandez, D. Brown

Source: NC State University Libraries
Added: August 6, 2018

2014 article

Live Attenuated Tetravalent Dengue Virus Host Range Vaccine Is Immunogenic in African Green Monkeys following a Single Vaccination

Briggs, C. M., Smith, K. M., Piper, A., Huitt, E., Spears, C. J., Quiles, M., … Hernandez, R. (2014, April 3). Journal of Virology.

By: C. Briggs*, K. Smith *, A. Piper n, E. Huitt*, C. Spears *, M. Quiles*, M. Ribeiro n, M. Thomas*, D. Brown n, R. Hernandez n

MeSH headings : Animals; Antibodies, Viral / immunology; Chlorocebus aethiops; Dengue / immunology; Dengue / prevention & control; Dengue / virology; Dengue Vaccines / administration & dosage; Dengue Vaccines / genetics; Dengue Vaccines / immunology; Dengue Virus / classification; Dengue Virus / genetics; Dengue Virus / immunology; Dengue Virus / physiology; Host Specificity; Humans; Species Specificity; Vaccination; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / genetics; Vaccines, Attenuated / immunology; Viral Envelope Proteins / administration & dosage; Viral Envelope Proteins / genetics; Viral Envelope Proteins / immunology
topics (OpenAlex): Mosquito-borne diseases and control; Viral Infections and Vectors; Malaria Research and Control
TL;DR: A live attenuated viral (LAV) vaccine capable of eliciting a strong immune response in African green monkeys (AGMs) in a single dose is generated, and this study suggests that viremia and antibody response in AGMs may be similar to those seen in DENV infection in humans. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 article

Chikungunya Virus Host Range E2 Transmembrane Deletion Mutants Induce Protective Immunity against Challenge in C57BL/6J Mice

Piper, A., Ribeiro, M., Smith, K. M., Briggs, C. M., Huitt, E., Nanda, K., … Hernandez, R. (2013, April 4). Journal of Virology.

By: A. Piper n, M. Ribeiro n, K. Smith *, C. Briggs*, E. Huitt*, K. Nanda *, C. Spears *, M. Quiles* ...

MeSH headings : Alphavirus Infections / immunology; Alphavirus Infections / prevention & control; Alphavirus Infections / virology; Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; Cell Line; Chikungunya Fever; Chikungunya virus / genetics; Chikungunya virus / immunology; Chikungunya virus / pathogenicity; Chikungunya virus / physiology; Host Specificity; Humans; Mice; Mice, Inbred C57BL; Mutation; Sequence Deletion; Vaccines, Attenuated / genetics; Vaccines, Attenuated / immunology; Viral Vaccines / genetics; Viral Vaccines / immunology; Virus Replication
topics (OpenAlex): Mosquito-borne diseases and control; Viral Infections and Vectors; Virology and Viral Diseases
TL;DR: This study identified a ChikV HR mutant that grows to high levels in insect cells but was restricted in the ability to assemble virus in mammalian cells in vitro. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

Stowe, S. D., Tucker, A. T., Thompson, R., Piper, A., Richards, J. J., Rogers, S. A., … Cavanagh, J. (2012, January 31). Drug and Chemical Toxicology.

By: S. Stowe n, A. Tucker*, R. Thompson*, A. Piper*, J. Richards*, S. Rogers*, L. Mathies n, C. Melander*, J. Cavanagh*

author keywords: 2-aminoimidazole; adjuvant; biofilm; Caenorhabditis elegans; toxicity; Toxicity of 2-aminoimidazole; antibiofilm agents
MeSH headings : Adjuvants, Pharmaceutic / toxicity; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / toxicity; Biofilms / drug effects; Caenorhabditis elegans; Cell Line; Dose-Response Relationship, Drug; Environmental Exposure; Fertility / drug effects; Humans; Imidazoles / pharmacology; Imidazoles / toxicity; Keratinocytes / metabolism; Tetrazolium Salts; Thiazoles; Toxicity Tests
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Nanoparticles: synthesis and applications
TL;DR: The most effective antibiofilm compound had significant effects when used in conjunction with several standard antibiotics against resistant bacteria and was found to maintain the same low level of toxicity as when acting alone, bolstering its candidacy for further testing as an adjuvant. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Testing of Novel Dengue Virus 2 Vaccines in African Green Monkeys: Safety, Immunogenicity, and Efficacy

Smith, K. M., Nanda, K., Spears, C. J., Piper, A., Ribeiro, M., Quiles, M., … McCarl, V. (2012, September 21). American Journal of Tropical Medicine and Hygiene.

By: K. Smith, K. Nanda, C. Spears, A. Piper*, M. Ribeiro, M. Quiles, C. Briggs, G. Thomas ...

MeSH headings : Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; Cells, Cultured; Chlorocebus aethiops; Dengue / immunology; Dengue / prevention & control; Dengue / virology; Dengue Vaccines / adverse effects; Dengue Vaccines / genetics; Dengue Vaccines / immunology; Dengue Vaccines / therapeutic use; Dengue Virus / genetics; Dengue Virus / immunology; Immunization; Neutralization Tests; Viral Envelope Proteins / genetics; Viral Envelope Proteins / immunology; Viral Plaque Assay
topics (OpenAlex): Mosquito-borne diseases and control; Viral Infections and Vectors; Malaria Research and Control
TL;DR: Three novel host-range vaccines containing deletions in the transmembrane domain of dengue virus serotype 2 (DV2) E glycoprotein were evaluated in African green monkeys, and all three vaccine strains decreased the length of viremia by at least two days. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 article

Conformational Changes in Sindbis Virus Induced by Decreased pH Are Revealed by Small-Angle Neutron Scattering

He, L., Piper, A., Meilleur, F., Hernandez, R., Heller, W. T., & Brown, D. T. (2011, December 8). Journal of Virology, Vol. 86, pp. 1982–1987.

By: L. He *, A. Piper n, F. Meilleur n , R. Hernandez n, W. Heller * & D. Brown n

Contributors: L. He *, A. Piper n, F. Meilleur n , R. Hernandez n, W. Heller * & D. Brown n

MeSH headings : Hydrogen-Ion Concentration; RNA, Viral / chemistry; RNA, Viral / genetics; RNA, Viral / metabolism; Scattering, Small Angle; Sindbis Virus / chemistry; Sindbis Virus / genetics; Sindbis Virus / metabolism; Viral Proteins / chemistry; Viral Proteins / genetics; Virion / chemistry; Virion / genetics; Virion / metabolism
topics (OpenAlex): Viral gastroenteritis research and epidemiology; Bacteriophages and microbial interactions; Viral Infections and Outbreaks Research
TL;DR: Small-angle neutron scattering with contrast variation is employed to probe how the structure of a mammalian-grown Sindbis virus responds to moderately acidic pH and improves the understanding of the pH-driven alteration of Sind Bis virus structure. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 article

Structural mutants of dengue virus 2 transmembrane domains exhibit host-range phenotype

Smith, K. M., Nanda, K., Spears, C. J., Ribeiro, M., Vancini, R., Piper, A., … Hernandez, R. (2011, June 9). Virology Journal.

By: K. Smith *, K. Nanda *, C. Spears *, M. Ribeiro n, R. Vancini n, A. Piper n, G. Thomas*, M. Thomas*, D. Brown n, R. Hernandez n

MeSH headings : Aedes; Amino Acid Sequence; Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; Cell Line; Dengue Virus / genetics; Dengue Virus / immunology; Dengue Virus / pathogenicity; Dengue Virus / physiology; Host Specificity; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Sequence Data; Mutant Proteins / genetics; Mutant Proteins / immunology; Mutant Proteins / metabolism; Sequence Deletion; Viral Envelope Proteins / genetics; Viral Envelope Proteins / immunology; Viral Envelope Proteins / metabolism
topics (OpenAlex): Mosquito-borne diseases and control; Viral Infections and Vectors; Viral Infections and Outbreaks Research
TL;DR: Novel host-range mutants of DV2 were created that have preferential growth in insect cells and impaired infectivity in mammalian cells and may be applied to many other insect-borne viral diseases for which no current effective therapies exist. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

The Structure of Sindbis Virus Produced from Vertebrate and Invertebrate Hosts as Determined by Small-Angle Neutron Scattering

He, L., Piper, A., Meilleur, F., Myles, D. A. A., Hernandez, R., Brown, D. T., & Heller, W. T. (2010, March 11). Journal of Virology, Vol. 84, pp. 5270–5276.

By: L. He *, A. Piper n, F. Meilleur n , D. Myles *, R. Hernandez n, D. Brown n, W. Heller *

Contributors: L. He *, A. Piper n, F. Meilleur n , D. Myles *, R. Hernandez n, D. Brown n, W. Heller *

MeSH headings : Animals; Cell Line; Cricetinae; Culicidae; Scattering, Small Angle; Sindbis Virus / chemistry; Sindbis Virus / growth & development; Virion / chemistry; Virion / isolation & purification
topics (OpenAlex): Mosquito-borne diseases and control; Viral Infections and Vectors; Viral gastroenteritis research and epidemiology
TL;DR: The first study of the structural differences between Sindbis viruses grown in mammalian and insect cells are reported, which were determined by small-angle neutron scattering (SANS), a nondestructive technique that did not decrease the infectivity of the Sindbis virus particles studied. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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