James A. Raleigh

Works (4)

Updated: July 5th, 2023 16:04

1997 article

Hypoxia marker labeling in tumor biopsies: quantification of labeling variation and criteria for biopsy sectioning

Thrall, D. E., Rosner, G. L., Azuma, C., McEntee, M. C., & Raleigh, J. A. (1997, August 1). Radiotherapy and Oncology.

By: D. Thrall n, G. Rosner *, C. Azuma n, M. McEntee n & J. Raleigh*

author keywords: hypoxia; canine tumors; nitroimidazole markers; hypoxia markers; CCI-103F; sampling error
MeSH headings : Animals; Biopsy; Cell Hypoxia; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Neoplasms / metabolism; Neoplasms / pathology; Neoplasms / veterinary; Nitroimidazoles
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Virus-based gene therapy research; Cancer Research and Treatments
TL;DR: Comparing the intrabiopsy distribution of CCI-103F, a 2-nitroimidazole hypoxia marker, in dogs bearing spontaneous solid tumors found quantification of the labeled area in four randomly selected slides from a biopsy can provide an estimate of the labeling area in the biopsy within an absolute range of +/-0.05. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 article

Longevity of Pimonidazole Adducts in Spontaneous Canine Tumors as an Estimate of Hypoxic Cell Lifetime

Azuma, C., Raleigh, J. A., & Thrall, D. E. (1997, July 1). Radiation Research.

By: C. Azuma n, J. Raleigh* & D. Thrall*

topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Virus-based gene therapy research; Cancer Research and Treatments
TL;DR: The longevity of pimonidazole adducts in tumors was quantified as an estimate of the lifetime of hypoxic cells and there was no relationship in individual tumors between the relative change in antigen concentration and therelative change in labeled area fraction. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 article

Proliferation and hypoxia in human squamous cell carcinoma of the cervix: First report of combined immunohistochemical assays

Kennedy, A. S., Raleigh, J. A., Perez, G. M., Calkins, D. P., Thrall, D. E., Novotny, D. B., & Varia, M. A. (1997, March 1). International Journal of Radiation Oncology*Biology*Physics.

By: A. Kennedy, J. Raleigh*, G. Perez*, D. Calkins*, D. Thrall*, D. Novotny n, M. Varia*

author keywords: hypoxia; proliferation; hypoxia marker; pimonidazole; MIB-1; PCNA; cervix carcinoma
MeSH headings : Adult; Antigens, Nuclear; Biomarkers; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / pathology; Carcinoma, Squamous Cell / physiopathology; Cell Division; Cell Hypoxia / physiology; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Nitroimidazoles / metabolism; Nuclear Proteins / metabolism; Proliferating Cell Nuclear Antigen / metabolism; Radiation-Sensitizing Agents / metabolism; Uterine Cervical Neoplasms / metabolism; Uterine Cervical Neoplasms / pathology; Uterine Cervical Neoplasms / physiopathology
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; RNA modifications and cancer; Cancer-related molecular mechanisms research
TL;DR: Investigation of immunohistochemical staining for pimonidazole binding in primary squamous cell carcinoma of the cervix uteri found it consistent with the presence of hypoxic cells in human tumors and may be useful for estimating tumor hypoxia before radiation therapy. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 article

Quantification of CCI-103F labeling heterogeneity in canine solid tumors

Cline, J. M., Rosner, G. L., Raleigh, J. A., & Thrall, D. E. (1997, February 1). International Journal of Radiation Oncology*Biology*Physics.

By: J. Cline  n, G. Rosner *, J. Raleigh* & D. Thrall n

author keywords: hypoxia; canine tumors; nitroimidazole markers; hypoxia markers; CCI-103F; sampling error
MeSH headings : Analysis of Variance; Animals; Biomarkers; Cell Hypoxia; Dog Diseases / pathology; Dogs; Neoplasms / pathology; Neoplasms / veterinary; Nitroimidazoles; Oxygen / analysis; Reproducibility of Results
topics (OpenAlex): Cancer, Hypoxia, and Metabolism; Virus-based gene therapy research; Cancer Research and Treatments
TL;DR: Despite intratumor variation, acceptable estimates of nitroimidazole-labeled cells in a tumor may be obtained from a clinically feasible number of biopsies. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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