Works (1)
Updated: July 5th, 2023 15:48
2010 journal article
Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(23), 7976–7981.
MeSH headings : Apoptosis / drug effects; Base Sequence; Carcinoma, Hepatocellular / drug therapy; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Enoxacin / pharmacology; HeLa Cells; Hepatitis C / drug therapy; Hepatitis C / genetics; Humans; Liver Neoplasms / drug therapy; Liver Neoplasms / genetics; Liver Neoplasms / pathology; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; MicroRNAs / metabolism; Oligonucleotides, Antisense / genetics; Oligonucleotides, Antisense / pharmacology; Virus Replication / drug effects; Virus Replication / genetics
TL;DR:
The authors' small molecule inhibitors reduce viral replication in liver cells and represent a new approach to the treatment of HCV infections and small molecule activation of miR-122 in liver cancer cells selectively induced apoptosis through caspase activation, thus having implications in cancer chemotherapy.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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