Christoph Grohmann

Works (1)

Updated: July 5th, 2023 15:48

2010 journal article

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(23), 7976–7981.

By: D. Young n, C. Connelly n, C. Grohmann n & A. Deiters n

MeSH headings : Apoptosis / drug effects; Base Sequence; Carcinoma, Hepatocellular / drug therapy; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Enoxacin / pharmacology; HeLa Cells; Hepatitis C / drug therapy; Hepatitis C / genetics; Humans; Liver Neoplasms / drug therapy; Liver Neoplasms / genetics; Liver Neoplasms / pathology; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; MicroRNAs / metabolism; Oligonucleotides, Antisense / genetics; Oligonucleotides, Antisense / pharmacology; Virus Replication / drug effects; Virus Replication / genetics
TL;DR: The authors' small molecule inhibitors reduce viral replication in liver cells and represent a new approach to the treatment of HCV infections and small molecule activation of miR-122 in liver cancer cells selectively induced apoptosis through caspase activation, thus having implications in cancer chemotherapy. (via Semantic Scholar)
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