Michael R. Zalutsky

Works (9)

Updated: July 5th, 2023 16:00

2004 journal article

Enhanced tumour uptake of radiolabelled antibodies by hyperthermia. Part II: Application of the thermal equivalency equation

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 21(1), 13–27.

By: M. Hauck n & M. Zalutsky*

author keywords: hyperthermia; monoclonal antibody; thermal isodose; combined modality therapies; radioimmunotherapy
MeSH headings : Animals; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Neoplasm / pharmacology; Brain Neoplasms / therapy; Cell Line, Tumor; Combined Modality Therapy; Glioma / therapy; Humans; Hyperthermia, Induced / methods; Iodine Radioisotopes / pharmacology; Mice; Mice, Inbred BALB C; Mice, Nude; Radiation Dosage; Radioimmunotherapy / methods; Temperature; Xenograft Model Antitumor Assays
TL;DR: Differences in absolute tumour and normal tissue uptake were seen, suggesting that the thermal isodose formula has limited usefulness in the design and comparison of hyperthermia protocols for enhancing the tumour uptake of radiolabelled mAbs. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 journal article

Enhanced tumour uptake of radiolabelled antibodies by hyperthermia: Part I: Timing of injection relative to hyperthermia

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 21(1), 1–11.

By: M. Hauck n & M. Zalutsky*

author keywords: hyperthermia; monoclonal antibody; combined modality therapies; radioimmunotherapy
MeSH headings : Animals; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Neoplasm / pharmacology; Brain Neoplasms / therapy; Cell Line, Tumor; Combined Modality Therapy; Glioma / therapy; Humans; Hyperthermia, Induced / methods; Iodine Radioisotopes / pharmacology; Mice; Mice, Inbred BALB C; Mice, Nude; Radioimmunotherapy / methods; Tenascin / immunology; Xenograft Model Antitumor Assays
TL;DR: Tumour targeting mAbs administered in combination with heat may be injected either prior to or immediately following hyperthermia treatment, with the expectation that levels of uptake in tumour will be relatively equivalent. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Imaging of Pheochromocytoma in 2 dogs using p-[18F] Fluorobenzylguanidine

Veterinary Radiology and Ultrasound, 43(2), 183–186.

By: C. Berry n, T. Degrado*, F. Nutter n, P. Garg*, E. Breitschwerdt n , K. Spaulding n, K. Concannon n, M. Zalutsky*, R. Edward Coleman*

author keywords: canine; p-[F-18]fluorobenzylguanidine; pheochromocytoma
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dogs; Female; Fluorine Radioisotopes / metabolism; Pheochromocytoma / diagnostic imaging; Pheochromocytoma / veterinary; Tomography, Emission-Computed
TL;DR: The results indicate that [18F]PFBG may be useful for imaging canine pheochromocytomas and aid in differentiating adrenal masses. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1998 journal article

Cytotoxicity of alpha-particle emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia

BRITISH JOURNAL OF CANCER, 77(5), 753–759.

By: M. Hauck*, R. Larsen *, P. Welsh & M. Zalutsky*

author keywords: monoclonal antibody; hyperthermia; spheroid; astatine-211; alpha-emitter
MeSH headings : Alpha Particles; Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / metabolism; Antibodies, Monoclonal / therapeutic use; Antibody Specificity; Astatine / therapeutic use; Biological Transport; Gliosarcoma / pathology; Humans; Hyperthermia, Induced; Immunoglobulin G / immunology; Immunoglobulin G / metabolism; Immunoglobulin G / therapeutic use; Mice; Organoids / immunology; Organoids / metabolism; Organoids / radiation effects; Radioimmunotherapy; Recombinant Fusion Proteins / immunology; Recombinant Fusion Proteins / metabolism; Recombinant Fusion Proteins / therapeutic use; Tenascin / immunology; Tumor Cells, Cultured / radiation effects
TL;DR: Results and those from autoradiographs indicate that hyperthermia at 42 degrees C for 1 h had no significant effect on the uptake or distribution of this antitenascin MAb in D-247 MG spheroids. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 journal article

The effects of local hyperthermia on the catabolism of a radioiodinated chimeric monoclonal antibody

Clinical Cancer Research, 4, 2071–2077.

By: M. Hauck & M. Zalutsky

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 13(3), 307–316.

By: M. Hauck*, D. Coffin*, R. Dodge*, M. Dewhirst*, J. Mitchell * & M. Zalutsky*

author keywords: interstitial fluid pressure; xenograft; hyperthermia
MeSH headings : Animals; Antibodies, Monoclonal / pharmacokinetics; Antibodies, Monoclonal / therapeutic use; Biological Transport, Active; Combined Modality Therapy; Extracellular Space / physiology; Glioma / immunology; Glioma / physiopathology; Glioma / therapy; Humans; Hyperthermia, Induced / methods; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Pressure; Time Factors; Transplantation, Heterologous
TL;DR: It is demonstrated that local hyperthermia (4 h, 41.8 degrees C) is capable of significantly enhancing the uptake of radiolabelled monoclonal antibodies (mAbs) in D-54 MG glioma xenografts grown subcutaneously in athymic mice. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model

Clinical Cancer Research, 3, 63–70.

By: M. Hauck, M. Dewhirst, D. Bigner & M. Zaultsky

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

The effects of clinically relevant hyperthermic temperatures on the kinetic binding parameters of a monoclonal antibody

NUCLEAR MEDICINE AND BIOLOGY, 23(4), 551–557.

By: M. Hauck*, M. Dewhirst* & M. Zalutsky*

author keywords: monoclonal antibodies; hyperthermia; antibody binding kinetics; radiotherapy
MeSH headings : Animals; Antibodies, Monoclonal / metabolism; Antibodies, Monoclonal / pharmacokinetics; Dogs; Glioma / metabolism; Humans; Hyperthermia, Induced; Kinetics; Mice; Mice, Nude; Osteosarcoma / metabolism; Tumor Cells, Cultured
TL;DR: The effects of clinically relevant levels of hyperthermia on the kinetic binding parameters were investigated for 81C6, an antibody undergoing Phase I/II clinical trials for the treatment of brain tumors and neoplastic meningitis. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1995 chapter

Enhancement of radiolabeled monoclonal antibody uptake in tumors with local hyperthermia

In Handbook of targeted delivery of imaging agents (pp. 333–359).

By: M. Hauck, M. Dewhirst & M. Zalutsky

Source: NC State University Libraries
Added: August 6, 2018

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