Thomas B. Kepler

A linear two-state model with complex dynamics

PHYSICS LETTERS A, 280(4), 204–208.

Improved inference of mutation rates - II. Generalization of the Luria-Delbruck distribution for realistic cell-cycle time distributions

THEORETICAL POPULATION BIOLOGY, 59(1), 49–59.

Stochasticity in transcriptional regulation: Origins, consequences, and mathematical representations

BIOPHYSICAL JOURNAL, 81(6), 3116–3136.

Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood

Mathematical Biosciences, 170(1), 59–77.

Quantitative evaluation of alternative mechanisms of blood disposition of di(n-butyl) phthalate and mono(n-butyl) phthalate in rats

TOXICOLOGICAL SCIENCES, 53(2), 173–184.

The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation

JOURNAL OF IMMUNOLOGY, 164(4), 1971–1976.

Enhanced evolvability in immunoglobulin V genes under somatic hypermutation

JOURNAL OF MOLECULAR EVOLUTION, 49(1), 23–26.

Genetic plasticity of V genes under somatic hypermutation: Statistical analyses using a new resampling-based methodology

GENOME RESEARCH, 9(12), 1294–1304.

Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors

AIDS RESEARCH AND HUMAN RETROVIRUSES, 15(13), 1219–1228.

Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination

JOURNAL OF CLINICAL INVESTIGATION, 103(6), 833–841.

Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats

TOXICOLOGICAL SCIENCES, 49(2), 172–185.

Density-dependent prenatal androgen exposure as an endogenous mechanism for the generation of cycles in small mammal populations

JOURNAL OF THEORETICAL BIOLOGY, 190(1), 93–106.

Drug concentration heterogeneity facilitates the evolution of drug resistance

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(20), 11514–11519.

Plasticity under somatic mutation in antigen receptors

In G. Kelsoe & M. F. Flajnik (Eds.), Somatic diversification of immune responses (Current topics in microbiology and immunology ; 229) (Vol. 229, pp. 149–162). Berlin; New York: Springer.

Predicted and inferred waiting times for key mutations in the germinal centre reaction: Evidence for stochasticity in selection

IMMUNOLOGY AND CELL BIOLOGY, 76(4), 373–381.

The distribution of variation in regulatory gene segments, as present in MHC class II promoters

GENOME RESEARCH, 8(2), 124–134.

Codon bias and plasticity in immunoglobulins

MOLECULAR BIOLOGY AND EVOLUTION, 14(6), 637–643.

Interdependence of N nucleotide addition and recombination site choice in V(D)J rearrangement

Journal of Immunology, 157(10), 4451.

Cellular interaction in germinal-centers - roles of cd40 ligand and b7-2 in established germinal-centers

Journal of Immunology, 155(2), 556–567.