Works (19)

2001 journal article

A linear two-state model with complex dynamics

Physics Letters. A, 280(4), 204–208.

By: T. Elston & T. Kepler

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Improved inference of mutation rates - II. Generalization of the Luria-Delbruck distribution for realistic cell-cycle time distributions

Theoretical Population Biology, 59(1), 49–59.

By: M. Oprea & T. Kepler

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Stochasticity in transcriptional regulation: Origins, consequences, and mathematical representations

Biophysical Journal, 81(6), 3116–3136.

By: T. Kepler & T. Elston

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood

Mathematical Biosciences, 170(1), 59–77.

By: M. Radmacher & T. Kepler

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Quantitative evaluation of alternative mechanisms of blood disposition of di(n-butyl) phthalate and mono(n-butyl) phthalate in rats

Toxicological Sciences, 53(2), 173–184.

By: D. Keys, D. Wallace, T. Kepler & R. Conolly

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation

Journal of Immunology, 164(4), 1971–1976.

By: L. Cowell & T. Kepler

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Enhanced evolvability in immunoglobulin V genes under somatic hypermutation

Journal of Molecular Evolution, 49(1), 23–26.

By: L. Cowell, H. Kim, T. Humaljoki, C. Berek & T. Kepler

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Genetic plasticity of V genes under somatic hypermutation: Statistical analyses using a new resampling-based methodology

Genome Research, 9(12), 1294–1304.

By: M. Oprea & T. Kepler

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors

AIDS Research and Human Retroviruses, 15(13), 1219–1228.

By: M. Betts, J. Krowka, T. Kepler, M. Davidian, C. Christopherson, S. Kwok, L. Louie, J. Eron, H. Sheppard, J. Frelinger

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination

Journal of Clinical Investigation, 103(6), 833–841.

By: L. Gangi-Peterson, D. Sorscher, J. Reynolds, T. Kepler & B. Mitchell

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2- ethylhexyl) phthalate in rats

Toxicological Sciences, 49(2), 172–185.

By: D. Keys, D. Wallace, T. Kepler & R. Conolly

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Density-dependent prenatal androgen exposure as an endogenous mechanism for the generation of cycles in small mammal populations

Journal of Theoretical Biology, 190(1), 93–106.

By: L. Cowell, L. Crowder & T. Kepler

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Drug concentration heterogeneity facilitates the evolution of drug resistance

Proceedings of the National Academy of Sciences of the United States of America, 95(20), 11514–11519.

By: T. Kepler & A. Perelson

Source: NC State University Libraries
Added: August 6, 2018

1998 chapter

Plasticity under somatic mutation in antigen receptors

In G. Kelsoe & M. F. Flajnik (Eds.), Somatic diversification of immune responses (Current topics in microbiology and immunology ; 229) (Vol. 229, pp. 149–162). Berlin; New York: Springer.

By: T. Kepler & S. Bartl

Ed(s): . G. Kelsoe & M. Flajnik

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Predicted and inferred waiting times for key mutations in the germinal centre reaction: Evidence for stochasticity in selection

Immunology and Cell Biology, 76(4), 373–381.

By: M. Radmacher, G. Kelsoe & T. Kepler

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

The distribution of variation in regulatory gene segments, as present in MHC class II promoters

Genome Research, 8(2), 124–134.

By: L. Cowell, T. Kepler, M. Janitz, R. Lauster & N. Mitchison

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Codon bias and plasticity in immunoglobulins

Molecular Biology and Evolution, 14(6), 637–643.

By: T. Kepler

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Interdependence of N nucleotide addition and recombination site choice in V(D)J rearrangement

Journal of Immunology, 157(10), 4451.

By: T. Kepler, M. Borrero, B. Rugerio, S. McCray & S. Clarke

Source: NC State University Libraries
Added: August 6, 2018

1995 journal article

Cellular interaction in germinal-centers - roles of cd40 ligand and b7-2 in established germinal-centers

Journal of Immunology, 155(2), 556–567.

By: S. Han, K. Hathcock, B. Zheng, T. Kepler, R. Hodes & G. Kelsoe

Source: NC State University Libraries
Added: August 6, 2018