Thomas B. Kepler

Works (19)

Updated: July 5th, 2023 16:04
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2001 journal article

A linear two-state model with complex dynamics

PHYSICS LETTERS A, 280(4), 204–208.

By: T. Elston n & T. Kepler*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Improved inference of mutation rates - II. Generalization of the Luria-Delbruck distribution for realistic cell-cycle time distributions

THEORETICAL POPULATION BIOLOGY, 59(1), 49–59.

By: M. Oprea & T. Kepler*

MeSH headings : Algorithms; Bias; Cell Cycle / genetics; Confidence Intervals; Data Interpretation, Statistical; Genetics, Population; Models, Genetic; Mutation / genetics; Phenotype; Phylogeny; Population Density; Statistical Distributions; Time Factors
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Stochasticity in transcriptional regulation: Origins, consequences, and mathematical representations

BIOPHYSICAL JOURNAL, 81(6), 3116–3136.

By: T. Kepler n & T. Elston n

co-author countries: United States of America 🇺🇸
MeSH headings : Feedback, Physiological; Gene Expression Regulation; Models, Theoretical; Monte Carlo Method; Promoter Regions, Genetic; Stochastic Processes; Time Factors; Transcription, Genetic
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood

Mathematical Biosciences, 170(1), 59–77.

By: M. Radmacher & T. Kepler

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Quantitative evaluation of alternative mechanisms of blood disposition of di(n-butyl) phthalate and mono(n-butyl) phthalate in rats

TOXICOLOGICAL SCIENCES, 53(2), 173–184.

By: D. Keys n, D. Wallace, T. Kepler* & R. Conolly

co-author countries: United States of America 🇺🇸
author keywords: phthalates; DBP; MBP; PBPK; model; flow-limited; diffusion-limited; pH trapping; enterohepatic circulation; log-likelihood ratio test
MeSH headings : Administration, Oral; Animals; Dibutyl Phthalate / analysis; Dibutyl Phthalate / pharmacokinetics; Environmental Pollutants / blood; Environmental Pollutants / pharmacokinetics; Injections, Intravenous; Male; Models, Biological; Phthalic Acids / blood; Phthalic Acids / pharmacokinetics; Rats; Rats, Sprague-Dawley; Rats, Wistar
Source: Web Of Science
Added: August 6, 2018

2000 journal article

The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation

JOURNAL OF IMMUNOLOGY, 164(4), 1971–1976.

By: L. Cowell  n & T. Kepler n

co-author countries: United States of America 🇺🇸
MeSH headings : Adenine / immunology; Animals; Base Composition; Base Sequence; DNA Mutational Analysis / methods; DNA Mutational Analysis / statistics & numerical data; Gene Rearrangement; Germ-Line Mutation / immunology; Humans; Immunoglobulin Variable Region / genetics; Mice; Nucleotides / genetics; Nucleotides / immunology; Pseudogenes / immunology; Thymine / immunology
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Enhanced evolvability in immunoglobulin V genes under somatic hypermutation

JOURNAL OF MOLECULAR EVOLUTION, 49(1), 23–26.

By: L. Cowell  n, H. Kim*, T. Humaljoki*, C. Berek* & T. Kepler n

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
author keywords: genome evolution; adaptability; somatic hypermutation; affinity maturation
MeSH headings : Arthritis / genetics; Arthritis / immunology; Arthritis, Rheumatoid / genetics; Arthritis, Rheumatoid / immunology; DNA, Complementary / genetics; Evolution, Molecular; Gene Frequency; Genes, Immunoglobulin; Humans; Immunoglobulin Variable Region / genetics; Mutation; Selection, Genetic; Serine / genetics
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Genetic plasticity of V genes under somatic hypermutation: Statistical analyses using a new resampling-based methodology

GENOME RESEARCH, 9(12), 1294–1304.

By: M. Oprea & T. Kepler*

MeSH headings : Base Sequence; Codon; Computational Biology; Genes, T-Cell Receptor / genetics; Humans; Immunoglobulin Variable Region / genetics; Molecular Sequence Data; Mutation; Phylogeny; Sequence Analysis, DNA
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors

AIDS RESEARCH AND HUMAN RETROVIRUSES, 15(13), 1219–1228.

By: M. Betts, J. Krowka, T. Kepler*, M. Davidian* , C. Christopherson, S. Kwok, L. Louie, J. Eron, H. Sheppard, J. Frelinger

MeSH headings : CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes / immunology; Cross-Sectional Studies; Cytotoxicity Tests, Immunologic; Gene Products, pol / genetics; Gene Products, pol / metabolism; HIV Infections / immunology; HIV Infections / virology; HIV Long-Term Survivors; HIV-1 / immunology; HIV-1 / physiology; Histocompatibility Antigens Class I / classification; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Humans; Longitudinal Studies; Male; Receptors, CCR5 / genetics; T-Lymphocytes, Cytotoxic / immunology; Viral Load
Sources: Web Of Science, ORCID
Added: August 6, 2018

1999 journal article

Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination

JOURNAL OF CLINICAL INVESTIGATION, 103(6), 833–841.

By: L. Gangi-Peterson, D. Sorscher, J. Reynolds, T. Kepler* & B. Mitchell

MeSH headings : Adenosine Deaminase / deficiency; Adenosine Deaminase Inhibitors; Adenosine Triphosphate / metabolism; Cells, Cultured; DNA Nucleotidylexotransferase / metabolism; Deoxyadenosines / pharmacology; Deoxyguanine Nucleotides / metabolism; Deoxyribonucleotides / metabolism; Gene Rearrangement, B-Lymphocyte; Humans; Immunoglobulin M / genetics; Purine-Pyrimidine Metabolism, Inborn Errors / enzymology; Recombination, Genetic; Sequence Analysis, DNA
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats

TOXICOLOGICAL SCIENCES, 49(2), 172–185.

By: D. Keys, D. Wallace, T. Kepler & R. Conolly

author keywords: phthalates; DEHP; MEHP; PBPK; model; flow-limited; diffusion-limited; pH trapping; enterohepatic circulation; log-likelihood ratio test
MeSH headings : Animals; Diffusion; Enterohepatic Circulation / physiology; Hydrogen-Ion Concentration; Male; Models, Biological; Phthalic Acids / blood; Phthalic Acids / pharmacokinetics; Plasticizers / metabolism; Rats; Rats, Sprague-Dawley; Solubility; Testis / metabolism
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Density-dependent prenatal androgen exposure as an endogenous mechanism for the generation of cycles in small mammal populations

JOURNAL OF THEORETICAL BIOLOGY, 190(1), 93–106.

By: L. Cowell  n, L. Crowder* & T. Kepler n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Drug concentration heterogeneity facilitates the evolution of drug resistance

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(20), 11514–11519.

By: T. Kepler n & A. Perelson  n

co-author countries: United States of America 🇺🇸
author keywords: sanctuary sites; HIV
MeSH headings : Anti-HIV Agents / administration & dosage; Anti-HIV Agents / pharmacokinetics; Anti-HIV Agents / pharmacology; Biological Evolution; Drug Resistance, Microbial / genetics; HIV Infections / drug therapy; HIV Infections / metabolism; HIV Infections / virology; HIV-1 / drug effects; HIV-1 / genetics; HIV-1 / physiology; Humans; Mathematics; Models, Biological; Mutation; Virus Replication
Source: Web Of Science
Added: August 6, 2018

1998 chapter

Plasticity under somatic mutation in antigen receptors

In G. Kelsoe & M. F. Flajnik (Eds.), Somatic diversification of immune responses (Current topics in microbiology and immunology ; 229) (Vol. 229, pp. 149–162). Berlin; New York: Springer.

By: T. Kepler & S. Bartl

Ed(s): . G. Kelsoe & M. Flajnik

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Predicted and inferred waiting times for key mutations in the germinal centre reaction: Evidence for stochasticity in selection

IMMUNOLOGY AND CELL BIOLOGY, 76(4), 373–381.

By: M. Radmacher n, G. Kelsoe * & T. Kepler n

co-author countries: United States of America 🇺🇸
author keywords: b-lymphocytes; germinal centre; immunoglobulins; maximum likelihood estimates; statistical models
MeSH headings : Animals; Cell Differentiation; Germinal Center; Humans; Mutation; Stochastic Processes; Time Factors
Source: Web Of Science
Added: August 6, 2018

1998 journal article

The distribution of variation in regulatory gene segments, as present in MHC class II promoters

GENOME RESEARCH, 8(2), 124–134.

By: L. Cowell *, T. Kepler n, M. Janitz *, R. Lauster* & N. Mitchison*

co-author countries: Belgium 🇧🇪 Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Animals; Binding Sites / genetics; Binding Sites / immunology; Chickens; Genes, MHC Class II; Genetic Variation / genetics; Genetic Variation / immunology; Humans; Mice; Mole Rats; Promoter Regions, Genetic / immunology; Regulatory Sequences, Nucleic Acid / immunology; Selection, Genetic; Sequence Analysis, DNA; Species Specificity; Zebrafish
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Codon bias and plasticity in immunoglobulins

MOLECULAR BIOLOGY AND EVOLUTION, 14(6), 637–643.

By: T. Kepler*

author keywords: codon bias; immunoglobulin; somatic mutation; hypermutation; immunity
MeSH headings : Amino Acids / genetics; Binding Sites; Codon; Genetic Variation; Humans; Immunoglobulin Variable Region / genetics; Immunoglobulins / physiology; Linear Models; Models, Genetic; Molecular Sequence Data; Mutation; Selection, Genetic; Sequence Alignment
Source: Web Of Science
Added: August 6, 2018

1996 journal article

Interdependence of N nucleotide addition and recombination site choice in V(D)J rearrangement

Journal of Immunology, 157(10), 4451.

By: T. Kepler, M. Borrero, B. Rugerio, S. McCray & S. Clarke

Source: NC State University Libraries
Added: August 6, 2018

1995 journal article

Cellular interaction in germinal-centers - roles of cd40 ligand and b7-2 in established germinal-centers

Journal of Immunology, 155(2), 556–567.

By: S. Han, K. Hathcock, B. Zheng, T. Kepler, R. Hodes & G. Kelsoe

Source: NC State University Libraries
Added: August 6, 2018