Thomas B. Kepler

Elston, T. C., & Kepler, T. B. (2001). A linear two-state model with complex dynamics. PHYSICS LETTERS A, 280(4), 204–208. https://doi.org/10.1016/S0375-9601(01)00052-4

Oprea, M., & Kepler, T. B. (2001). Improved inference of mutation rates - II. Generalization of the Luria-Delbruck distribution for realistic cell-cycle time distributions. THEORETICAL POPULATION BIOLOGY, 59(1), 49–59. https://doi.org/10.1006/tpbi.2000.1504

Kepler, T. B., & Elston, T. C. (2001). Stochasticity in transcriptional regulation: Origins, consequences, and mathematical representations. BIOPHYSICAL JOURNAL, 81(6), 3116–3136. https://doi.org/10.1016/S0006-3495(01)75949-8

Radmacher, M. D., & Kepler, T. B. (2001). Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood. Mathematical Biosciences, 170(1), 59–77.

Keys, D. A., Wallace, D. G., Kepler, T. B., & Conolly, R. B. (2000). Quantitative evaluation of alternative mechanisms of blood disposition of di(n-butyl) phthalate and mono(n-butyl) phthalate in rats. TOXICOLOGICAL SCIENCES, 53(2), 173–184. https://doi.org/10.1093/toxsci/53.2.173

Cowell, L. G., & Kepler, T. B. (2000). The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation. JOURNAL OF IMMUNOLOGY, 164(4), 1971–1976. https://doi.org/10.4049/jimmunol.164.4.1971

Cowell, L. G., Kim, H. J., Humaljoki, T., Berek, C., & Kepler, T. B. (1999). Enhanced evolvability in immunoglobulin V genes under somatic hypermutation. JOURNAL OF MOLECULAR EVOLUTION, 49(1), 23–26. https://doi.org/10.1007/PL00006530

Oprea, M., & Kepler, T. B. (1999). Genetic plasticity of V genes under somatic hypermutation: Statistical analyses using a new resampling-based methodology. GENOME RESEARCH, 9(12), 1294–1304. https://doi.org/10.1101/gr.9.12.1294

Betts, M. R., Krowka, J. F., Kepler, T. B., Davidian, M., Christopherson, C., Kwok, S., … Frelinger, J. A. (1999). Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors. AIDS RESEARCH AND HUMAN RETROVIRUSES, 15(13), 1219–1228. https://doi.org/10.1089/088922299310313

Gangi-Peterson, L., Sorscher, D. H., Reynolds, J. W., Kepler, T. B., & Mitchell, B. S. (1999). Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination. JOURNAL OF CLINICAL INVESTIGATION, 103(6), 833–841. https://doi.org/10.1172/JCI4320

Keys, D. A., Wallace, D. G., Kepler, T. B., & Conolly, R. B. (1999). Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats. TOXICOLOGICAL SCIENCES, 49(2), 172–185. https://doi.org/10.1093/toxsci/49.2.172

Cowell, L. G., Crowder, L. B., & Kepler, T. B. (1998). Density-dependent prenatal androgen exposure as an endogenous mechanism for the generation of cycles in small mammal populations. JOURNAL OF THEORETICAL BIOLOGY, 190(1), 93–106. https://doi.org/10.1006/jtbi.1997.0543

Kepler, T. B., & Perelson, A. S. (1998). Drug concentration heterogeneity facilitates the evolution of drug resistance. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(20), 11514–11519. https://doi.org/10.1073/pnas.95.20.11514

Kepler, T. B., & Bartl, S. (1998). Plasticity under somatic mutation in antigen receptors. In G. Kelsoe & M. F. Flajnik (Eds.), Somatic diversification of immune responses (Current topics in microbiology and immunology ; 229) (Vol. 229, pp. 149–162). Berlin; New York: Springer.

Radmacher, M. D., Kelsoe, G., & Kepler, T. B. (1998). Predicted and inferred waiting times for key mutations in the germinal centre reaction: Evidence for stochasticity in selection. IMMUNOLOGY AND CELL BIOLOGY, 76(4), 373–381. https://doi.org/10.1046/j.1440-1711.1998.00753.x

Cowell, L. G., Kepler, T. B., Janitz, M., Lauster, R., & Mitchison, N. A. (1998). The distribution of variation in regulatory gene segments, as present in MHC class II promoters. GENOME RESEARCH, 8(2), 124–134. https://doi.org/10.1101/gr.8.2.124

Kepler, T. B. (1997). Codon bias and plasticity in immunoglobulins. MOLECULAR BIOLOGY AND EVOLUTION, 14(6), 637–643. https://doi.org/10.1093/oxfordjournals.molbev.a025803

Kepler, T. B., Borrero, M., Rugerio, B., McCray, S. K., & Clarke, S. H. (1996). Interdependence of N nucleotide addition and recombination site choice in V(D)J rearrangement. Journal of Immunology, 157(10), 4451.

Han, S. H., Hathcock, K., Zheng, B., Kepler, T. B., Hodes, R., & Kelsoe, G. (1995). Cellular interaction in germinal-centers - roles of cd40 ligand and b7-2 in established germinal-centers. Journal of Immunology, 155(2), 556–567.