Patricia E. Levi

Works (8)

Updated: July 5th, 2023 16:04

2001 journal article

Modulation of mouse P450 isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the environmental chemicals mirex, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene, vinclozolin, and flutamide

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 70(3), 127–141.

By: D. Dai*, Y. Cao n, G. Falls*, P. Levi n, E. Hodgson n & R. Rose n

TL;DR: It is demonstrated that structurally diverse environmental chemicals including mirex, 2,2-Bis( p -chlorophenyl)-1,1-dichloroethylene (DDE), vinclozolin, and flutamide are capable of inducing several mouse liver CYP isozymes that may significantly impact testosterone metabolism and this may be a contributing factor in their antiandrogenic effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5)

Journal of Biochemical and Molecular Toxicology, 12(1998), 205–212.

By: N. Cherrington n, J. Falls n, R. Rose n, K. Clements n, R. Philpot*, P. Levi n, E. Hodgson n

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Regulation of hepatic CYP1A isozymes by piperonyl butoxide and acenaphthylene in the mouse

CHEMICO-BIOLOGICAL INTERACTIONS, 105(1), 53–63.

By: D. Ryu n, P. Levi n & E. Hodgson n

author keywords: piperonyl butoxide; acenaphthylene; CYP1A1; CYP1A2; Ah receptor; C57BL/6; DBA/2; Ah receptor knockout (AHR(-/-)) mouse
MeSH headings : Acenaphthenes / pharmacology; Animals; Blotting, Northern; Blotting, Western; Cycloheximide / pharmacology; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 Enzyme System / genetics; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Isoenzymes / genetics; Liver / enzymology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperonyl Butoxide / pharmacology; Polychlorinated Dibenzodioxins / pharmacology; Polymerase Chain Reaction / methods; RNA, Heterogeneous Nuclear / analysis; RNA-Directed DNA Polymerase; Teratogens / pharmacology
TL;DR: The results suggest that PBO, but not ACN, induces CYP1A1 through a weak activation of AHR, and it is assumed that the transcriptional induction of CYP 1A2 by PBO and ACN is AHR-independent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 article

Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids

Falls, J. G., Ryu, D. Y., Cao, Y., Levi, P. E., & Hodgson, E. (1997, June 15). ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol. 342, pp. 212–223.

By: J. Falls n, D. Ryu n, Y. Cao n, P. Levi n & E. Hodgson n

author keywords: flavin-containing monooxygenases; FM01; FM03; FM05; FMO expression; hormonal regulation; testosterone; 17 beta-estradiol; progesterone
MeSH headings : Animals; Blotting, Western; Castration; Estradiol / blood; Estradiol / pharmacology; Female; Gene Expression Regulation, Enzymologic; Isoenzymes / metabolism; Liver / drug effects; Liver / enzymology; Male; Mice; Mice, Inbred Strains; Microsomes, Liver / metabolism; Organ Size / drug effects; Ovariectomy; Oxygenases / metabolism; Progesterone / blood; Progesterone / pharmacology; RNA, Messenger / metabolism; Seminal Vesicles / drug effects; Testosterone / blood; Testosterone / pharmacology; Uterus / drug effects
TL;DR: In males and females, F MO5 levels were unaffected by gonadectomy or hormone administration, thus indicating a sex hormone-independent mechanism of regulation for this isoform, and Interestingly, FMO1 protein levels were increased in sexually intact males following treatment with 17 beta-estradiol; however, only a slight increase in FMO3 protein level was observed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 book

Textbook of modern toxicology

Stamford, Conn.: Appleton & Lange.

By: E. Hodgson & P. Levi

Source: NC State University Libraries
Added: August 6, 2018

1992 journal article

ENZYMATIC AND IMMUNOHISTOCHEMICAL STUDIES ON THE ROLE OF CYTOCHROME-P450 AND THE FLAVIN-CONTAINING MONOOXYGENASE OF MOUSE SKIN IN THE METABOLISM OF PESTICIDES AND OTHER XENOBIOTICS

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 43(1), 53–66.

By: K. Venkatesh n, P. Levi n, A. Inman n, N. Monteiroriviere  n, R. Misra  n & E. Hodgson n

Contributors: K. Venkatesh n, P. Levi n, A. Inman n, N. Monteiroriviere  n, R. Misra  n & E. Hodgson n

TL;DR: Although the overall phorate sulfoxidation rate in mouse skin microsomes was only 3 to 4% of the rate seen in liver, FMO appears to assume a greater relative role to P450 in the metabolic processes in skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1992 journal article

INDUCTION OF CYTOCHROME-P450-4A1 IN MOUSE-LIVER BY THE HERBICIDE SYNERGIST TRIDIPHANE

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 44(1), 9–14.

By: P. Levi n, R. Rose n, N. Adams n & E. Hodgson n

TL;DR: There was a 10-fold elevation in microsomal hydroxylation of lauric acid, an activity specifically associated with induction of P450 4A1, and Western blot analysis using an antibody specific for P450 3A1 showed a dramatic increase in P4504A1. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1988 journal article

DIFFERENCES IN OXIDATIVE DEARYLATION AND DESULFURATION OF FENITROTHION BY CYTOCHROME-P-450 ISOZYMES AND IN THE SUBSEQUENT INHIBITION OF MONOOXYGENASE ACTIVITY

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 32(3), 224–231.

By: P. Levi n, R. Hollingworth* & E. Hodgson n

TL;DR: Microsomes prepared from mice treated in vivo with organophosphates, such as fenitrothion, have reduced levels of cytochrome P -450 and associated monooxygenase activities Presumably, this reduction is due to destruction of P - 450 caused by the release of active sulfur occurring during desulfuration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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