Patricia E. Levi

Works (8)

Updated: February 10th, 2025 16:10

2001 article

Modulation of Mouse P450 Isoforms CYP1A2, CYP2B10, CYP2E1, and CYP3A by the Environmental Chemicals Mirex, 2,2-Bis(p-chlorophenyl)-1,1-dichloroethylene, Vinclozolin, and Flutamide

Dai, D., Cao, Y., Falls, G., Levi, P. E., Hodgson, E., & Rose, R. L. (2001, July 1). Pesticide Biochemistry and Physiology.

By: D. Dai*, Y. Cao n, G. Falls*, P. Levi n, E. Hodgson n & R. Rose n

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Effects and risks of endocrine disrupting chemicals; Hormonal and reproductive studies
TL;DR: It is demonstrated that structurally diverse environmental chemicals including mirex, 2,2-Bis( p -chlorophenyl)-1,1-dichloroethylene (DDE), vinclozolin, and flutamide are capable of inducing several mouse liver CYP isozymes that may significantly impact testosterone metabolism and this may be a contributing factor in their antiandrogenic effects. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 article

Molecular Cloning, Sequence, and Expression of Mouse Flavin‐Containing Monooxygenases 1 and 5 (FMO1 and FMO5)

Cherrington, N. J., Falls, J. G., Rose, R. L., Clements, K. M., Philpot, R. M., Levi, P. E., & Hodgson, E. (1998, January 1). Journal of Biochemical and Molecular Toxicology.

By: N. Cherrington n, J. Falls n, R. Rose n, K. Clements n, R. Philpot*, P. Levi n, E. Hodgson n

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Pesticide and Herbicide Environmental Studies
Source: NC State University Libraries
Added: August 6, 2018

1997 article

Regulation of Mouse Liver Flavin-Containing Monooxygenases 1 and 3 by Sex Steroids

Falls, J. G., Ryu, D.-Y., Cao, Y., Levi, P. E., & Hodgson, E. (1997, June 1). Archives of Biochemistry and Biophysics.

By: J. Falls*, D. Ryu  n, Y. Cao n, P. Levi n & E. Hodgson n

author keywords: flavin-containing monooxygenases; FM01; FM03; FM05; FMO expression; hormonal regulation; testosterone; 17 beta-estradiol; progesterone
MeSH headings : Animals; Blotting, Western; Castration; Estradiol / blood; Estradiol / pharmacology; Female; Gene Expression Regulation, Enzymologic; Isoenzymes / metabolism; Liver / drug effects; Liver / enzymology; Male; Mice; Mice, Inbred Strains; Microsomes, Liver / metabolism; Organ Size / drug effects; Ovariectomy; Oxygenases / metabolism; Progesterone / blood; Progesterone / pharmacology; RNA, Messenger / metabolism; Seminal Vesicles / drug effects; Testosterone / blood; Testosterone / pharmacology; Uterus / drug effects
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Estrogen and related hormone effects; Neuroscience and Neuropharmacology Research
TL;DR: In males and females, F MO5 levels were unaffected by gonadectomy or hormone administration, thus indicating a sex hormone-independent mechanism of regulation for this isoform, and Interestingly, FMO1 protein levels were increased in sexually intact males following treatment with 17 beta-estradiol; however, only a slight increase in FMO3 protein level was observed. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 article

Regulation of hepatic CYP1A isozymes by piperonyl butoxide and acenaphthylene in the mouse

Ryu, D.-Y., Levi, P. E., & Hodgson, E. (1997, June 1). Chemico-Biological Interactions.

By: D. Ryu, P. Levi n & E. Hodgson n

author keywords: piperonyl butoxide; acenaphthylene; CYP1A1; CYP1A2; Ah receptor; C57BL/6; DBA/2; Ah receptor knockout (AHR(-/-)) mouse
MeSH headings : Acenaphthenes / pharmacology; Animals; Blotting, Northern; Blotting, Western; Cycloheximide / pharmacology; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A2 / genetics; Cytochrome P-450 Enzyme System / genetics; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Isoenzymes / genetics; Liver / enzymology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperonyl Butoxide / pharmacology; Polychlorinated Dibenzodioxins / pharmacology; Polymerase Chain Reaction / methods; RNA, Heterogeneous Nuclear / analysis; RNA-Directed DNA Polymerase; Teratogens / pharmacology
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Toxic Organic Pollutants Impact
TL;DR: The results suggest that PBO, but not ACN, induces CYP1A1 through a weak activation of AHR, and it is assumed that the transcriptional induction of CYP 1A2 by PBO and ACN is AHR-independent. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 book

Textbook of modern toxicology

Stamford, Conn.: Appleton & Lange.

By: E. Hodgson & P. Levi

Source: NC State University Libraries
Added: August 6, 2018

1992 article

Enzymatic and immunohistochemical studies on the role of cytochrome P450 and the flavin-containing monooxygenase of mouse skin in the metabolism of pesticides and other xenobiotics

Venkatesh, K., Levi, P. E., Inman, A. O., Monteiro-Riviere, N. A., Misra, R., & Hodgson, E. (1992, May 1). Pesticide Biochemistry and Physiology, Vol. 43, pp. 53–66.

By: K. Venkatesh n, P. Levi n, A. Inman n, N. Monteiro-Riviere n , R. Misra  n & E. Hodgson n

Contributors: K. Venkatesh n, P. Levi n, A. Inman n, N. Monteiroriviere n , R. Misra  n & E. Hodgson n

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Pesticide and Herbicide Environmental Studies
TL;DR: Although the overall phorate sulfoxidation rate in mouse skin microsomes was only 3 to 4% of the rate seen in liver, FMO appears to assume a greater relative role to P450 in the metabolic processes in skin. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1992 article

Induction of cytochrome P450 4A1 in mouse liver by the herbicide synergist tridiphane

Levi, P. E., Rose, R. L., Adams, N. H., & Hodgson, E. (1992, September 1). Pesticide Biochemistry and Physiology.

By: P. Levi n, R. Rose n, N. Adams n & E. Hodgson n

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Drug Transport and Resistance Mechanisms; Drug-Induced Hepatotoxicity and Protection
TL;DR: There was a 10-fold elevation in microsomal hydroxylation of lauric acid, an activity specifically associated with induction of P450 4A1, and Western blot analysis using an antibody specific for P450 3A1 showed a dramatic increase in P4504A1. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1988 article

Differences in oxidative dearylation and desulfuration of fenitrothion by cytochrome P-450 isozymes and in the subsequent inhibition of monooxygenase activity

Levi, P. E., Hollingworth, R. M., & Hodgson, E. (1988, November 1). Pesticide Biochemistry and Physiology.

By: P. Levi n, R. Hollingworth* & E. Hodgson n

topics (OpenAlex): Pesticide Exposure and Toxicity; Pesticide and Herbicide Environmental Studies; Environmental Toxicology and Ecotoxicology
TL;DR: Microsomes prepared from mice treated in vivo with organophosphates, such as fenitrothion, have reduced levels of cytochrome P -450 and associated monooxygenase activities Presumably, this reduction is due to destruction of P - 450 caused by the release of active sulfur occurring during desulfuration. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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