Hui-qin Wang

MeSH headings : Animals; Blotting, Northern; Carcinoma, Embryonal / metabolism; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Nucleus / metabolism; Enzyme Activation; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Developmental; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 4; MAP Kinase Kinase Kinases / metabolism; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinases / metabolism; Neurons / metabolism; Phosphoprotein Phosphatases / metabolism; Precipitin Tests; Protein Phosphatase 2C; Signal Transduction; Transfection; Tretinoin / metabolism; Tubulin / metabolism

TL;DR: It is demonstrated that activities of MAPK kinase 4 and TAK1, one of the upstream kinases of MKK4, were enhanced in the neurally differentiating cells and suggest that two distinct TAK 1-MKK4-JNK signaling pathways are independently activated at the different intracellular locations and may participate in the regulation of the neural differentiation of P19 cells. (via Semantic Scholar)

author keywords: mirex; skin; 17 beta-estradiol; tumor promotion; endocrine

MeSH headings : Animals; Carcinogens / toxicity; Cell Line; Chlordecone / toxicity; Drug Implants; Estradiol / administration & dosage; Estradiol / pharmacology; Female; Genes, Reporter / drug effects; Insecticides / toxicity; Luciferases / biosynthesis; Male; Mice; Mirex / toxicity; Orchiectomy; Ovariectomy; Radioimmunoassay; Sex Characteristics

TL;DR: Collectively, these studies indicate that E2 is a major ovarian hormone responsible for mirex tumor promotion sensitivity in female mice. (via Semantic Scholar)

MeSH headings : Animals; Arachidonic Acid / metabolism; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cells, Cultured; Cyclooxygenase 2; Cytosol / enzymology; Dinoprostone / metabolism; Enzyme Inhibitors / pharmacology; Inflammation / metabolism; Isoenzymes / antagonists & inhibitors; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratins / genetics; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Phospholipases A / metabolism; Phospholipids / metabolism; Phosphorylation / drug effects; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases / biosynthesis; Protein Isoforms / genetics; Protein Kinase C / antagonists & inhibitors; Protein Kinase C / genetics; Protein Kinase C / metabolism; Protein Kinase C-alpha; Signal Transduction / drug effects; Signal Transduction / physiology; Skin / drug effects; Skin / metabolism; Tetradecanoylphorbol Acetate / pharmacology

TL;DR: It is indicated that epidermal PKC alpha coordinately regulates cPLA(2) activity and COX-2 expression resulting in increased levels of AA and PGE(2), and MEK-dependent and C/EBP beta-independent events. (via Semantic Scholar)