Works (20)

Updated: July 5th, 2023 16:03

2011 journal article

Investigation of lifted jet flames stabilization mechanism using RANS simulations

FIRE SAFETY JOURNAL, 46(5), 254–261.

By: W. Wang n & T. Echekki n

Contributors: W. Wang n & T. Echekki n

author keywords: Lift-off; Stability; CFX; EDM; RANS; Triple flames
TL;DR: The simulation results show that the EDM model reproduces a mean partially-premixed flame structure at the leading edge of the lifted flame, with very good predictions of the lift-off height for lifted flames without co-flow. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2002 review

Boronic acid-based sensors

[Review of ]. CURRENT ORGANIC CHEMISTRY, 6(14), 1285–1317.

By: W. Wang*, X. Gao* & B. Wang*

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

A new OsO4-mediated carbon-carbon bond cleavage reaction leading to the formation of anthraquinone

Chemistry Letters, (1), 48–49.

By: S. Gao, W. Wang & B. Wang

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Building fluorescent sensors for carbohydrates using template-directed polymerizations

BIOORGANIC CHEMISTRY, 29(5), 308–320.

By: S. Gao n, W. Wang & B. Wang

author keywords: fluorescence; chemical sensor; boronic acid; molecular imprinting; polymerization; saccharides
MeSH headings : Biosensing Techniques / methods; Boronic Acids / chemistry; Carbohydrates / analysis; Carbohydrates / chemistry; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Glucose / chemistry; Molecular Structure; Polymers / chemical synthesis; Polymers / chemistry; Spectrometry, Fluorescence
TL;DR: A fluorescent monomer is designed and synthesized that allows for the preparation of fluorescent sensors of cis diols using molecular imprinting methods and showed significant fluorescence intensity enhancement upon binding with the template carbohydrate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

The development of photometric sensors for boronic acids

BIOORGANIC CHEMISTRY, 29(5), 259–270.

By: G. Springsteen n, C. Ballard n, S. Gao n, W. Wang n & B. Wang n

author keywords: boron; boronic acid; sensor; diethanolamine; PET
MeSH headings : Azo Compounds / chemical synthesis; Azo Compounds / chemistry; Biosensing Techniques; Boronic Acids / analysis; Boronic Acids / chemical synthesis; Boronic Acids / chemistry; Electrons; Equipment Design; Esters / chemical synthesis; Evaluation Studies as Topic; Molecular Structure; Organometallic Compounds / chemical synthesis; Organometallic Compounds / chemistry; Oxidation-Reduction; Photochemistry; Photometry / methods
TL;DR: The design and synthesis of a series of photometric chemosensors for phenylboronic acid using diethanolamine as the recognition moiety is reported, demonstrating that sensors based on several different designs can be used for the detection of boronic acids. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 article

A coumarin-based prodrug strategy to improve the oral absorption of RGD peptidomimetics

Wang, W., Camenisch, G., Sane, D. C., Zhang, H. J., Hugger, E., Wheeler, G. L., … Wang, B. H. (2000, March 1). JOURNAL OF CONTROLLED RELEASE, Vol. 65, pp. 245–251.

By: W. Wang n, G. Camenisch*, D. Sane*, H. Zhang n, E. Hugger*, G. Wheeler*, R. Borchardt*, B. Wang n

author keywords: coumarin; fibrinogen; drug delivery; platelet; membrane permeability
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacokinetics; Anticoagulants / pharmacology; Biotransformation; Cell Line; Chemical Phenomena; Chemistry, Physical; Coumarins / administration & dosage; Coumarins / pharmacokinetics; Coumarins / pharmacology; Dogs; Half-Life; Humans; Mouth Mucosa / cytology; Mouth Mucosa / metabolism; Oligopeptides / pharmacokinetics; Platelet Aggregation Inhibitors / pharmacokinetics; Platelet Aggregation Inhibitors / pharmacology; Prodrugs; Receptors, Immunologic / metabolism; Tirofiban; Tyrosine / analogs & derivatives; Tyrosine / pharmacokinetics; Tyrosine / pharmacology
TL;DR: Several coumarin-based cyclic prodrugs of RGD analogs are synthesized, which have the two most polar functional groups, a carboxyl and an amino group, masked as an ester and an amide, respectively, and have higher membrane interaction potentials. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

A facilitated cyclic ether formation and its potential application in solid-phase peptide and organic synthesis

Chemical & Pharmaceutical Bulletin, 48(2), 238–244.

By: D. Shan, A. Zheng, C. Ballard, W. Wang, R. Borchardt & B. Wang

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Orally active peptidomimetic RGD analogs that are glycoprotein IIb/IIIa antagonists

Current Medicinal Chemistry, 7(4), 437–453.

By: W. Wang, R. Borchardt & B. Wang

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

The first fluorescent sensor for boronic and boric acids with sensitivity at sub-micromolar concentrations

Chemical Communications (Cambridge, England), (14), 1283–1284.

By: W. Wang, G. Springsteen, S. Gao & B. Wang

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Building fluorescent sensors by template polymerization: The preparation of a fluorescent sensor for D-Fructose

ORGANIC LETTERS, 1(8), 1209–1212.

By: W. Wang n, S. Gao n & B. Wang n

MeSH headings : Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Fructose / analysis; Polymers; Spectrometry, Fluorescence
TL;DR: A fluorescent monomer is designed and synthesized which allows for the preparation of fluorescent sensors of cis diols using molecular imprinting methods and was used for the Preparation of sensitive fluorescent sensors for D-fructose. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Building fluorescent sensors by template polymerization: The preparation of a fluorescent sensor for L-tryptophan

BIOORGANIC CHEMISTRY, 27(6), 463–476.

By: Y. Liao n, W. Wang n & B. Wang n

TL;DR: A new way of making polymeric fluorescent sensors using template polymerization or molecular imprinting techniques is studied, which does not require the de novo design of the complementary binding site and does not rely on any specific structural features of the template molecule or prior knowledge of its three-dimensional structure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

PHARMACEUTICAL RESEARCH, 16(1), 7–15.

By: O. Gudmundsson*, G. Pauletti*, W. Wang n, D. Shan n, H. Zhang n, B. Wang n, R. Borchardt*

author keywords: esterase-sensitive prodrugs; peptide delivery; opioid peptides; Caco-2 cells; membrane permeability; chemical and enzymatic stability
MeSH headings : Animals; Caco-2 Cells; Cell Membrane Permeability; Coumaric Acids / metabolism; Endorphins / metabolism; Enzyme Stability; Humans; Male; Molecular Sequence Data; Peptide Hydrolases / metabolism; Peptides, Cyclic / metabolism; Prodrugs; Rats; Rats, Sprague-Dawley
TL;DR: The cell permeation characteristics and the chemical and enzymatic stability of coumarinic acid-based cyclic pro-drugs were evaluated andcyclic prodrugs exhibited significantly greater stability against peptidase metabolism than did [Leu5]-enkephalin and DADLE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Prodrug approaches to the improved delivery of peptide drugs

Current Pharmaceutical Design, 5(4), 265–287.

By: W. Wang, J. Jiang, C. Ballard & B. Wang

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Synthesis and evaluation of novel coumarin-based esterase- sensitive cyclic prodrugs of peptidomimetic RGD analogs with improved membrane permeability

Chemical & Pharmaceutical Bulletin, 47(1), 90–95.

By: B. Wang, W. Wang, G. Camenisch, J. Elmo, H. Zhang & R. Borchardt

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers

JOURNAL OF PEPTIDE RESEARCH, 53(4), 370–382.

By: B. Wang n, K. Nimkar*, W. Wang n, H. Zhang*, D. Shan, O. Gudmundsson*, S. Gangwar*, T. Siahaan*, R. Borchardt*

author keywords: membrane transport; opioid peptide; physicochemical properties; prodrugs
MeSH headings : Amino Acid Sequence; Cell Membrane Permeability / drug effects; Chemical Phenomena; Chemistry, Physical; Coumaric Acids / chemistry; Enkephalin, Leucine / chemistry; Enkephalin, Leucine / pharmacology; Enkephalin, Leucine-2-Alanine / chemistry; Enkephalin, Leucine-2-Alanine / pharmacology; Esterases / metabolism; Membranes, Artificial; Models, Biological; Opioid Peptides / chemical synthesis; Opioid Peptides / chemistry; Opioid Peptides / metabolism; Peptides, Cyclic / chemical synthesis; Peptides, Cyclic / chemistry; Peptides, Cyclic / metabolism; Permeability; Phenylpropionates / chemistry; Prodrugs / chemical synthesis; Prodrugs / chemistry; Prodrugs / metabolism; Prodrugs / pharmacology; Structure-Activity Relationship
TL;DR: The enhanced cellular permeation of the cyclic prodrugs is apparently due to the alteration of their lipophilicity and hydrogen bonding potential, but not their molecular sizes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Two new improved approaches to the synthesis of coumarin-based prodrugs

TETRAHEDRON, 55(14), 4237–4254.

By: A. Zheng, W. Wang*, H. Zhang & B. Wang*

author keywords: hydrogenation; photochemistry; coumarin; isomerization
TL;DR: Two new approaches to the synthesis of coumarin-based, esterase-sensitive prodrugs are described, one of which is a photochemical approach taking advantage of the photoisomerization of cinnamic acid and its derivatives and the other through the catalytic hydrogenation of a triple bond. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

A comparison of the bioconversion rates and the Caco-2 cell permeation characteristics of coumarin-based cyclic prodrugs and methylester-based linear prodrugs of RGD peptidomimetics

PHARMACEUTICAL RESEARCH, 15(8), 1174–1181.

By: G. Camenisch*, W. Wang n, B. Wang n & R. Borchardt*

author keywords: esterase-sensitive prodrugs; peptidomimetic; chemical and enzymatic stability; Caco-2 cells; membrane permeability; drug delivery
MeSH headings : Animals; Caco-2 Cells; Coumarins / chemistry; Coumarins / pharmacokinetics; Drug Stability; Esters; Humans; Male; Molecular Mimicry; Oligopeptides / chemistry; Oligopeptides / pharmacokinetics; Permeability; Prodrugs / pharmacokinetics; Rats; Rats, Sprague-Dawley
TL;DR: The coumarin-based cyclic prodrugs 3a and 3b were chemically less stable, but metabolically more stable, than the methylester-based linear prodrug's, which were chemically more stable to chemical hydrolysis and more stable in biological media containing esterase activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Coumarin-based prodrugs. Part 3: Structural effects on the release kinetics of esterase-sensitive prodrugs of amines

BIOORGANIC & MEDICINAL CHEMISTRY, 6(4), 417–426.

By: B. Wang n, H. Zhang n, A. Zheng n & W. Wang n

author keywords: prodrug; coumarin; coumarinic acid; esterase; structural effect
MeSH headings : Amines / chemistry; Amines / metabolism; Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Coumarins / chemistry; Coumarins / metabolism; Esterases / metabolism; Half-Life; Kinetics; Liver / enzymology; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pharmaceutic Aids / chemistry; Pharmaceutic Aids / metabolism; Prodrugs / chemistry; Prodrugs / metabolism; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Swine
TL;DR: To study the structural effects on the release kinetics of a coumarin-based esterase-sensitive prodrug system, two series of compounds with varying structural features of the ester 'trigger' part and the amine 'drug' part were synthesized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Coupled electron-hole dynamics at the Si/SiO2 interface

PHYSICAL REVIEW LETTERS, 81(19), 4224–4227.

Source: Web Of Science
Added: August 6, 2018

1998 journal article

Enantioselective polymeric transporters for tryptophan, phenylalanine, and histidine prepared using molecular imprinting techniques

BIOORGANIC CHEMISTRY, 26(6), 309–322.

By: Y. Liao n, W. Wang n & B. Wang n

TL;DR: Polymeric molecular transporters prepared using molecular imprinting techniques with D -tryptophan, D -phenylalanine, and D -histidine as the templates were found to be able to transport the template amino acids across a hydrophobic chloroform layer in a U-tube at rates that were 1.34- to 3.8-fold higher than the transport of their L -enantiomers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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