Julie Fisher

Works (1)

Updated: July 5th, 2023 15:47

2011 journal article

Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

CHEMISTRY & BIOLOGY, 18(2), 252–263.

By: M. Dush n, A. McIver n, M. Parr n, D. Young n, J. Fisher n, D. Newman n, P. Sannes n, M. Hauck n, A. Deiters n, N. Nascone-Yoder n 

MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
TL;DR: A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2025) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.