Shana Rae Dalton

Works (1)

Updated: July 5th, 2023 16:01

2000 journal article

EGF receptors of hepatocytes from rats treated with phenobarbital are sensitized to down-regulation by phenobarbital in culture

TOXICOLOGY AND APPLIED PHARMACOLOGY, 165(2), 115–126.

By: . Dalton n, R. Jirtle * & S. Meyer n

author keywords: epidermal growth factor receptor; phenobarbital; CYP2B1/2; tumor promotion
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases; Barbiturates / pharmacology; Blotting, Northern; Blotting, Western; Carcinogens / pharmacology; Cells, Cultured; Cytochrome P-450 CYP2B1 / biosynthesis; Cytochrome P-450 Enzyme System / biosynthesis; Down-Regulation / drug effects; Enzyme Induction / drug effects; ErbB Receptors / drug effects; ErbB Receptors / metabolism; Female; Liver / cytology; Liver / drug effects; Liver / metabolism; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / pathology; Male; Phenobarbital / blood; Phenobarbital / pharmacology; Prohibitins; RNA / biosynthesis; RNA / isolation & purification; Rats; Rats, Inbred F344; Sodium-Potassium-Exchanging ATPase / metabolism; Steroid Hydroxylases / biosynthesis
TL;DR: A role for impaired EGFr function in PhB liver tumor promotion due to effects on existing EGFr protein is supported and it is suggested that EGFr down-regulation by PhB in culture is independent of CYP2B1/2 activity but shares mechanistic components involved in its transcriptional activation byPhB. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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