Barbara Wetmore

Works (1)

Updated: July 5th, 2023 16:02

1999 journal article

Evidence for site-specific bioactivation of alachlor in the olfactory mucosa of the Long-Evans rat

TOXICOLOGICAL SCIENCES, 49(2), 202–212.

By: B. Wetmore n, A. Mitchell, S. Meyer* & M. Genter*

author keywords: mutagenicity; nasal carcinogenicity; cell proliferation; olfactory mucosa; mouse lymphoma assay; alachlor
MeSH headings : Acetamides / metabolism; Animals; Biotransformation; Blotting, Western; Body Weight / drug effects; Cell Division / drug effects; Dose-Response Relationship, Drug; Herbicides / metabolism; Lymphoma / etiology; Male; Mice; Mutagenicity Tests; Mutagens / metabolism; Mutagens / toxicity; Mutation; Olfactory Mucosa / drug effects; Olfactory Mucosa / metabolism; Olfactory Mucosa / pathology; Rats; Rats, Long-Evans; Salmonella typhimurium / genetics; Time Factors
TL;DR: Alachlor was administered i.p. to male Long-Evans rats for up to 28 days at doses that are carcinogenic in chronic studies in order to study olfactory lesion development and alterations in cell proliferation, suggesting that target tissue bioactivation of alachlor results in the formation of one or more mutagenic metabolite(s), which may be critical in alACHlor-induced nasal tumorigenesis. (via Semantic Scholar)
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