Vickie J. Wilson

Works (2)

Updated: July 5th, 2023 16:03

2000 article

Cellular and Molecular Mechanisms of Action of Linuron: An Antiandrogenic Herbicide that Produces Reproductive Malformations in Male Rats

Lambright, C., Ostby, J., Bobseine, K., Wilson, V., Hotchkiss, A. K., Mann, P. C., & Gray, L. E. (2000, August 1). Toxicological Sciences.

By: C. Lambright*, J. Ostby, K. Bobseine, V. Wilson*, A. Hotchkiss*, P. Mann*, L. Gray

author keywords: androgen binding; flutamide; linuron; reproductive malformations; androgen receptor (AR) antagonists
MeSH headings : Abnormalities, Drug-Induced; Androgen Antagonists / toxicity; Animals; COS Cells; Dibutyl Phthalate / toxicity; Dihydrotestosterone / pharmacology; Dose-Response Relationship, Drug; Female; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / pathology; Herbicides / toxicity; Linuron / toxicity; Male; Pregnancy; Rats; Rats, Sprague-Dawley; Transcriptional Activation / drug effects
topics (OpenAlex): Sexual Differentiation and Disorders; Hormonal and reproductive studies; Reproductive Biology and Fertility
TL;DR: The hypothesis that linuron is an AR antagonist both in vivo and in vitro is supported, but it remains to be determined if linuron alters sexual differentiation by additional mechanisms of action. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 article

Endosulfan Elevates Testosterone Biotransformation and Clearance in CD-1 Mice

Wilson, V. S., & LeBlanc, G. A. (1998, January 1). Toxicology and Applied Pharmacology, Vol. 148, pp. 158–168.

By: V. Wilson n & G. LeBlanc n 

MeSH headings : Animals; Biotransformation; Body Weight / drug effects; Cytosol / drug effects; Cytosol / metabolism; Dose-Response Relationship, Drug; Endosulfan / toxicity; Estradiol / blood; Female; Hydrocarbons, Chlorinated; Insecticides / toxicity; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Male; Mice; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Organ Size / drug effects; Testosterone / pharmacokinetics
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Effects and risks of endocrine disrupting chemicals; Hormonal and reproductive studies
TL;DR: Results indicate that increases in testosterone biotransformation from endosulfan exposure can result in increases in the elimination of the steroid, however, homeostatic processes apparently compensate for the effect and minimize any consequences on serum hormone levels. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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