Vickie J. Wilson

author keywords: androgen binding; flutamide; linuron; reproductive malformations; androgen receptor (AR) antagonists

MeSH headings : Abnormalities, Drug-Induced; Androgen Antagonists / toxicity; Animals; COS Cells; Dibutyl Phthalate / toxicity; Dihydrotestosterone / pharmacology; Dose-Response Relationship, Drug; Female; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / pathology; Herbicides / toxicity; Linuron / toxicity; Male; Pregnancy; Rats; Rats, Sprague-Dawley; Transcriptional Activation / drug effects

topics (OpenAlex): Sexual Differentiation and Disorders; Hormonal and reproductive studies; Reproductive Biology and Fertility

TL;DR: The hypothesis that linuron is an AR antagonist both in vivo and in vitro is supported, but it remains to be determined if linuron alters sexual differentiation by additional mechanisms of action. (via Semantic Scholar)

MeSH headings : Animals; Biotransformation; Body Weight / drug effects; Cytosol / drug effects; Cytosol / metabolism; Dose-Response Relationship, Drug; Endosulfan / toxicity; Estradiol / blood; Female; Hydrocarbons, Chlorinated; Insecticides / toxicity; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Male; Mice; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Organ Size / drug effects; Testosterone / pharmacokinetics

topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Effects and risks of endocrine disrupting chemicals; Hormonal and reproductive studies

TL;DR: Results indicate that increases in testosterone biotransformation from endosulfan exposure can result in increases in the elimination of the steroid, however, homeostatic processes apparently compensate for the effect and minimize any consequences on serum hormone levels. (via Semantic Scholar)