Works (2)

Updated: July 5th, 2023 16:03

2000 journal article

Cellular and molecular mechanisms of action of linuron: An antiandrogenic herbicide that produces reproductive malformations in male rats


By: C. Lambright*, J. Ostby, K. Bobseine, V. Wilson*, A. Hotchkiss*, P. Mann*, L. Gray

author keywords: androgen binding; flutamide; linuron; reproductive malformations; androgen receptor (AR) antagonists
MeSH headings : Abnormalities, Drug-Induced; Androgen Antagonists / toxicity; Animals; COS Cells; Dibutyl Phthalate / toxicity; Dihydrotestosterone / pharmacology; Dose-Response Relationship, Drug; Female; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / pathology; Herbicides / toxicity; Linuron / toxicity; Male; Pregnancy; Rats; Rats, Sprague-Dawley; Transcriptional Activation / drug effects
TL;DR: The hypothesis that linuron is an AR antagonist both in vivo and in vitro is supported, but it remains to be determined if linuron alters sexual differentiation by additional mechanisms of action. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Endosulfan elevates testosterone biotransformation and clearance in CD-1 mice


By: V. Wilson n & G. LeBlanc n

MeSH headings : Animals; Biotransformation; Body Weight / drug effects; Cytosol / drug effects; Cytosol / metabolism; Dose-Response Relationship, Drug; Endosulfan / toxicity; Estradiol / blood; Female; Hydrocarbons, Chlorinated; Insecticides / toxicity; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Male; Mice; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Organ Size / drug effects; Testosterone / pharmacokinetics
TL;DR: Results indicate that increases in testosterone biotransformation from endosulfan exposure can result in increases in the elimination of the steroid, however, homeostatic processes apparently compensate for the effect and minimize any consequences on serum hormone levels. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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