Works (2)

Updated: July 5th, 2023 15:58

2003 journal article

Predictive toxicology: Benchmarking molecular descriptors and statistical methods


By: J. Feng n, L. Lurati n, H. Ouyang n, T. Robinson n, Y. Wang n, S. Yuan n, S. Young n

MeSH headings : Drug Design; Drug-Related Side Effects and Adverse Reactions; Models, Statistical; Pharmaceutical Preparations / chemistry; Predictive Value of Tests; Structure-Activity Relationship; Toxicology / methods
TL;DR: Combinations of different chemical descriptors and popular statistical methods were applied to the problem of predictive toxicology, suggesting that certain descriptors work better with specific statistical methods so there is a need for better understanding and for continued methods development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Stable transfection of the bovine NRAMP1 gene into murine RAW264.7 cells: effect on Brucella abortus survival

Infection and Immunity, 69(5), 3110–3119.

By: R. Barthel, J. Feng*, J. Piedrahita*, D. McMurray*, J. Templeton & L. Adams

MeSH headings : 3' Untranslated Regions; Animals; Base Sequence; Brucella abortus / growth & development; Carrier Proteins / genetics; Carrier Proteins / physiology; Cation Transport Proteins; Cattle; Cell Line; Interferon-gamma / pharmacology; Lipopolysaccharides / pharmacology; Macrophages / microbiology; Male; Membrane Proteins / genetics; Membrane Proteins / physiology; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Nitric Oxide / physiology; Transfection; Tumor Necrosis Factor-alpha / physiology
TL;DR: It is demonstrated that the 5′-flanking region of bovineNRAMP1, despite the lack of TATA and CAAT boxes, has a functional promoter capable of driving the expression of a transgene in murine macrophages. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

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