David Glenwood Allen

Works (4)

Updated: July 5th, 2023 16:02

2001 journal article

Analysis of interleukin-8 release from normal human epidermal keratinocytes exposed to aliphatic hydrocarbons: delivery of hydrocarbons to cell cultures via complexation with alpha-cyclodextrin

TOXICOLOGY IN VITRO, 15(6), 663–669.

By: D. Allen n, J. Riviere n & N. Monteiro-Riviere n 

Contributors: D. Allen n, J. Riviere n & N. Monteiro-Riviere n 

author keywords: keratinocyte; cytokine; jet fuel; hydrocarbon; cyclodextrin
MeSH headings : Cells, Cultured; Cyclodextrins / chemistry; Dose-Response Relationship, Drug; Drug Carriers / chemistry; Humans; Hydrocarbons / chemistry; Hydrocarbons / toxicity; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Kerosene / toxicity; Solubility; alpha-Cyclodextrins
TL;DR: These studies demonstrate that the etiology of proinflammatory cytokine expression due to jet fuel exposure may be due in large part to the aliphatic hydrocarbon components and provide additional evidence that hydrocarbons can be successfully delivered to cells in culture by encapsulating them in cyclodextrin inclusion complexes. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2001 journal article

Cytokine induction as a measure of cutaneous toxicity in primary and immortalized porcine keratinocytes exposed to jet fuels, and their relationship to normal human epidermal keratinocytes

TOXICOLOGY LETTERS, 119(3), 209–217.

By: D. Allen n, J. Riviere n & N. Monteiro-Riviere n 

Contributors: D. Allen n, J. Riviere n & N. Monteiro-Riviere n 

author keywords: immortalized keratinocyte; cytokine; jet fuel; toxicity
MeSH headings : Analysis of Variance; Animals; Biomarkers; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Female; Fuel Oils / toxicity; Humans; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / metabolism; RNA, Messenger / isolation & purification; Swine; Tumor Necrosis Factor-alpha / biosynthesis
TL;DR: The results suggest that porcine keratinocytes are susceptible to jet fuel toxicity, however, the responses of immortalized cells may vary from those of PKC and NHEK necessitating cautious interpretation of such data. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2000 journal article

Identification of early biomarkers of inflammation produced by keratinocytes exposed to jet fuels Jet A, JP-8, and JP-8(100)

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 14(5), 231–237.

By: D. Allen n, J. Riviere n & N. Monteiro-Riviere n 

Contributors: D. Allen n, J. Riviere n & N. Monteiro-Riviere n 

author keywords: epidermal keratinocyte; cytokine; jet fuel; biomarkers; inflammation
TL;DR: It is demonstrated that jet fuels induce the production and release of proinflammatory cytokines in NHEK and thus create the potential for chronic inflammation, which may contribute to the development or progression of disease states in the skin. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

1999 journal article

Alteration of cytokeratin expression following transdermal lidocaine hydrochloride iontophoresis

PHARMACEUTICAL RESEARCH, 16(9), 1487–1490.

By: D. Allen n & N. Monteiro-Riviere n 

Contributors: D. Allen n & N. Monteiro-Riviere n 

author keywords: iontophoresis; lidocaine; pig skin; cytokeratins
MeSH headings : Administration, Cutaneous; Anesthetics, Local / pharmacology; Animals; Cell Nucleus; Cytoskeleton / metabolism; Epidermis / chemistry; Epidermis / drug effects; Epidermis / metabolism; Female; Immunohistochemistry; Iontophoresis; Keratin-10; Keratins / analysis; Keratins / biosynthesis; Lidocaine / pharmacology; Swine
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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