Works (2)
Updated: July 5th, 2023 16:01
2002 article
Pharmacokinetics after intravenous and oral administration of enrofloxacin in sheep
Bermingham, E. C., & Papich, M. G. (2002, July). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 63, pp. 1012–1017.
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Biological Availability; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Cross-Over Studies; Enrofloxacin; Female; Fluoroquinolones; Half-Life; Injections, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics; Sheep / blood; Sheep / metabolism
TL;DR:
Enrofloxacin administered orally to sheep has a prolonged half-life and high oral bioavailability and was sufficient to achieve a plasma concentration of 8 to 10 times the minimum inhibitory concentration of any microorganism with an MIC < or = 0.29 microg/ml.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Pharmacokinetics of enrofloxacin administered intravenously and orally to foals
AMERICAN JOURNAL OF VETERINARY RESEARCH, 61(6), 706–709.
MeSH headings : Administration, Oral; Animals; Animals, Newborn / metabolism; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / metabolism; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Ciprofloxacin / blood; Computer Simulation; Cross-Over Studies; Enrofloxacin; Fluoroquinolones; Half-Life; Horses / metabolism; Injections, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / metabolism; Quinolones / pharmacokinetics; Regression Analysis
TL;DR:
Compared with adult horses given 5 mg of enrofloxacin/kg IV, foals have higher AUC0-infinity, longer t1/2beta, and lower clearance, and computer modeling suggests that 2.5 to 10 mg of dextrose/kg administered every 24 hours would be effective in foals, depending on minimum inhibitory concentration of the pathogen.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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