Eden Crow Bermingham

Works (2)

Updated: July 5th, 2023 16:01

2002 article

Pharmacokinetics after intravenous and oral administration of enrofloxacin in sheep

Bermingham, E. C., & Papich, M. G. (2002, July). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 63, pp. 1012–1017.

By: E. Bermingham n & M. Papich n 

MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Biological Availability; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Cross-Over Studies; Enrofloxacin; Female; Fluoroquinolones; Half-Life; Injections, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / pharmacokinetics; Sheep / blood; Sheep / metabolism
TL;DR: Enrofloxacin administered orally to sheep has a prolonged half-life and high oral bioavailability and was sufficient to achieve a plasma concentration of 8 to 10 times the minimum inhibitory concentration of any microorganism with an MIC < or = 0.29 microg/ml. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Pharmacokinetics of enrofloxacin administered intravenously and orally to foals

AMERICAN JOURNAL OF VETERINARY RESEARCH, 61(6), 706–709.

By: E. Bermingham n, M. Papich*  & S. Vivrette*

MeSH headings : Administration, Oral; Animals; Animals, Newborn / metabolism; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / metabolism; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Ciprofloxacin / blood; Computer Simulation; Cross-Over Studies; Enrofloxacin; Fluoroquinolones; Half-Life; Horses / metabolism; Injections, Intravenous / veterinary; Quinolones / administration & dosage; Quinolones / blood; Quinolones / metabolism; Quinolones / pharmacokinetics; Regression Analysis
TL;DR: Compared with adult horses given 5 mg of enrofloxacin/kg IV, foals have higher AUC0-infinity, longer t1/2beta, and lower clearance, and computer modeling suggests that 2.5 to 10 mg of dextrose/kg administered every 24 hours would be effective in foals, depending on minimum inhibitory concentration of the pathogen. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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