The role of multi-modality adjuvant chemotherapy and radiation in women with advanced stage endometrial cancer
GYNECOLOGIC ONCOLOGY, 107(2), 285–291.
By:
A. Secord*, L. Havrilesky*, V. Bae-Jump *, J. Chin*, B. Calingaert*, A. Bland*, T. Rutledge*, A. Berchuck*, D. Clarke-Pearson*, P. Gehrig*
author keywords: endometrial cancer; chemotherapy; radiotherapy
MeSH headings : Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Carcinoma / drug therapy; Carcinoma / pathology; Carcinoma / radiotherapy; Carcinoma / surgery; Chemotherapy, Adjuvant; Cyclophosphamide / administration & dosage; Doxorubicin / administration & dosage; Endometrial Neoplasms / drug therapy; Endometrial Neoplasms / pathology; Endometrial Neoplasms / radiotherapy; Endometrial Neoplasms / surgery; Female; Humans; Hysterectomy; Kaplan-Meier Estimate; Lymph Node Excision; Middle Aged; Neoplasm Staging; North Carolina / epidemiology; Odds Ratio; Ovariectomy; Platinum Compounds / administration & dosage; Proportional Hazards Models; Radiotherapy, Adjuvant; Retrospective Studies; Treatment Outcome
TL;DR:
Combined adjuvant chemotherapy and radiation was associated with improved survival in patients with advanced stage disease compared to either modality alone and future clinical trials are needed to prospectively evaluate multi-modality adjUvant therapy.
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