John Saathoff

Works (2)

Updated: July 5th, 2023 15:46

2012 article

Lack of Hydroxylated Fullerene Toxicity After Intravenous Administration to Female Sprague-Dawley Rats

Monteiro-Riviere, N. A., Linder, K. E., Inman, A. O., Saathoff, J. G., Xia, X.-R., & Riviere, J. E. (2012, April 1). Journal of Toxicology and Environmental Health, Vol. 75, pp. 367–373.

By: N. Monteiro-Riviere n , K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n

Contributors: N. Monteiro-Riviere n , K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n

MeSH headings : Animals; Blood Chemical Analysis; Drug Administration Schedule; Female; Fullerenes / administration & dosage; Fullerenes / chemistry; Fullerenes / toxicity; Injections, Intravenous; Liver / drug effects; Lymphocytes / drug effects; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / toxicity; Rats; Rats, Sprague-Dawley; Thymus Gland / drug effects; Toxicity Tests, Acute; Urinalysis
topics (OpenAlex): Fullerene Chemistry and Applications; Anesthesia and Neurotoxicity Research; Nanoparticles: synthesis and applications
TL;DR: These experiments suggest that this fullerol was well tolerated after iv administration to rats, and no clinically significant chemistry changes were observed after treatment. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 article

In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells

Saathoff, J. G., Inman, A. O., Xia, X. R., Riviere, J. E., & Monteiro-Riviere, N. A. (2011, September 23). Toxicology in Vitro, Vol. 25, pp. 2105–2112.

By: J. Saathoff n, A. Inman n, X. Xia n, J. Riviere n & N. Monteiro-Riviere n 

Contributors: J. Saathoff n, A. Inman n, X. Xia n, J. Riviere n & N. Monteiro-Riviere n 

author keywords: Hydroxylated fullerenes; Fullerenes; Cytotoxicity; Skin cells; Keratinocytes; Nanoparticles
MeSH headings : Biological Transport; Cell Survival; Cells, Cultured; Fullerenes / chemistry; Fullerenes / metabolism; Fullerenes / toxicity; Humans; Hydroxylation; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Microscopy, Electron, Transmission; Photoelectron Spectroscopy; Spectrometry, Fluorescence
topics (OpenAlex): Fullerene Chemistry and Applications; Graphene and Nanomaterials Applications; Anesthesia and Neurotoxicity Research
TL;DR: Results suggest that different hydroxylation of fullerenes caused no cytotoxicity or inflammation up to 8.55 μg/ml, and suggest that extrapolation across similar NP will be dependent upon surface chemistry and concentration which may affect the degree of agglomeration and thus biological effects. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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