@article{aoi_hu_lo_selim_olufsen_novak_2012, title={Impaired Cerebral Autoregulation Is Associated with Brain Atrophy and Worse Functional Status in Chronic Ischemic Stroke}, volume={7}, ISSN={["1932-6203"]}, DOI={10.1371/journal.pone.0046794}, abstractNote={Dynamic cerebral autoregulation (dCA) is impaired following stroke. However, the relationship between dCA, brain atrophy, and functional outcomes following stroke remains unclear. In this study, we aimed to determine whether impairment of dCA is associated with atrophy in specific regions or globally, thereby affecting daily functions in stroke patients. We performed a retrospective analysis of 33 subjects with chronic infarctions in the middle cerebral artery territory, and 109 age-matched non-stroke subjects. dCA was assessed via the phase relationship between arterial blood pressure and cerebral blood flow velocity. Brain tissue volumes were quantified from MRI. Functional status was assessed by gait speed, instrumental activities of daily living (IADL), modified Rankin Scale, and NIH Stroke Score. Compared to the non-stroke group, stroke subjects showed degraded dCA bilaterally, and showed gray matter atrophy in the frontal, parietal and temporal lobes ipsilateral to infarct. In stroke subjects, better dCA was associated with less temporal lobe gray matter atrophy on the infracted side ( = 0.029), faster gait speed ( = 0.018) and lower IADL score (0.002). Our results indicate that better dynamic cerebral perfusion regulation is associated with less atrophy and better long-term functional status in older adults with chronic ischemic infarctions.}, number={10}, journal={PLOS ONE}, author={Aoi, Mikio C. and Hu, Kun and Lo, Men-Tzung and Selim, Magdy and Olufsen, Mette S. and Novak, Vera}, year={2012}, month={Oct} }
 @article{aoi_rourke_2011, title={Interspecific and intragenic differences in codon usage bias among vertebrate myosin heavy-chain genes}, volume={73}, number={3-4}, journal={Journal of Molecular Evolution}, author={Aoi, M. C. and Rourke, B. C.}, year={2011}, pages={74–93} }
 @inproceedings{aoi_matzuka_olufsen_2011, title={Toward online, noninvasive, nonlinear assessment of cerebral autoregulation}, DOI={10.1109/iembs.2011.6090671}, abstractNote={Online estimation of cerebral autoregulation (CA) may be advantageous in neurosurgical and neurointensive care units. Data from transcranial Doppler, and continuous arterial blood pressure are readily available at high temporal resolution and may be used to assess CA. There are currently no methods for nonlinear, noninvasive, online assessment of CA. We frame the assessment of CA as a parameter estimation problem, in which we estimate the parameters of a nonlinear mathematical model of CA using the ensemble Kalman filter (EnKF). In this simulation study, we use the EnKF to estimate the parameters of a model of cerebral hemodynamics which predicts intracranial pressure and cerebral blood flow velocity, generated from real patient arterial blood pressure measurements. We examine the flexibility and appropriateness of the EnKF for CA assessment.}, booktitle={2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)}, author={Aoi, M. C. and Matzuka, B. J. and Olufsen, M. S.}, year={2011}, pages={2410–2413} }