Characterization of T-lymphocytes in the anterior uvea of eyes with chronic equine recurrent uveitis
Gilger, B. C., Malok, E., Cutter, K. V., Stewart, T., Horohov, D. W., & Allen, J. B. (1999, October 1). Veterinary Immunology and Immunopathology, Vol. 71, pp. 17–28.
author keywords: equine; uveitis; T-lymphocyte; cytokines; immunohistochemistry; QRT-PCR
MeSH headings : Animals; Chronic Disease; Ciliary Body / immunology; Ciliary Body / pathology; Cytokines / biosynthesis; Cytokines / genetics; Horse Diseases / immunology; Horse Diseases / pathology; Horses; Immunoenzyme Techniques / veterinary; Iris / immunology; Iris / pathology; RNA, Messenger / metabolism; Recurrence; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocyte Subsets / immunology; T-Lymphocytes / immunology; Uveitis, Anterior / immunology; Uveitis, Anterior / pathology; Uveitis, Anterior / veterinary
topics (OpenAlex): Toxoplasma gondii Research Studies; melanin and skin pigmentation
TL;DR:
The QRT-PCR results revealed increased transcription of IL-2 and IFNgamma and low IL-4 mRNA expression in eyes with chronic ERU compared to normal eyes, demonstrating a Thelper (Th) 1-like inflammatory response in Eyes with ERU.
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