Joshua Aaron Stern

Works (12)

Updated: July 5th, 2023 15:43

2015 journal article

Impact of the canine double-deletion beta 1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a beta 1-selective beta-blocker

PHARMACOGENETICS AND GENOMICS, 25(9), 427–431.

By: K. Meurs n , J. Stern, Y. Reina-Doreste n, B. Maran*, L. Chdid n, S. Lahmers*, B. Keene n, K. Mealey *

author keywords: beta-adrenergic receptor; atenolol; beta-blocker; canine; polymorphism
MeSH headings : Adrenergic beta-1 Receptor Antagonists / administration & dosage; Adrenergic beta-1 Receptor Antagonists / pharmacology; Animals; Atenolol / administration & dosage; Atenolol / pharmacology; Dogs; Electrocardiography / veterinary; Heart Rate / drug effects; Models, Molecular; Protein Structure, Secondary; Receptors, Adrenergic, beta-1 / chemistry; Receptors, Adrenergic, beta-1 / genetics; Sequence Deletion
TL;DR: The heart rates of the dogs with deletions were lower than those of the control dogs (the average heart rates were significantly lower), and individual genome-based treatment recommendations could impact the management of dogs with heart disease. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 article

Polymorphisms in the canine and feline renin-angiotensin-aldosterone system genes

Meurs, K. M., Chdid, L., Reina-Doreste, Y., & Stern, J. A. (2015, April). ANIMAL GENETICS, Vol. 46, pp. 226–226.

By: K. Meurs n , L. Chdid n, Y. Reina-Doreste n & J. Stern n 

MeSH headings : Animals; Cats; Dogs; Polymorphism, Genetic; Renin-Angiotensin System / genetics; Sequence Analysis, DNA
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Sudden Death Associated with QT Interval Prolongation and KCNQ1 Gene Mutation in a Family of English Springer Spaniels

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(2), 561–568.

By: W. Ware *, Y. Reina-Doreste n, J. Stern n  & K. Meurs n 

author keywords: Long QT Syndrome
MeSH headings : Animals; Arrhythmias, Cardiac / genetics; Arrhythmias, Cardiac / veterinary; Case-Control Studies; Death, Sudden / veterinary; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Genetic Predisposition to Disease; KCNQ1 Potassium Channel / genetics; KCNQ1 Potassium Channel / metabolism; Long QT Syndrome / complications; Long QT Syndrome / genetics; Male; Mutation; Pedigree
TL;DR: This family represents the first documentation in dogs of spontaneous familial QT prolongation, which was associated with a KCNQ1 gene mutation and sudden death, and their phenotypic manifestations of QT interval prolongation and abnormal ECG restitution suggested increased risk for sudden arrhythmic death. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs

Human Genetics, 133(9), 1139–1148.

By: J. Stern n , S. White *, L. Lehmkuhl, Y. Reina-Doreste n, J. Ferguson n, N. Nascone-Yoder n , K. Meurs n 

MeSH headings : Animals; Aortic Stenosis, Subvalvular / genetics; Aortic Stenosis, Subvalvular / pathology; Aortic Stenosis, Subvalvular / veterinary; Base Sequence; Case-Control Studies; Clathrin / antagonists & inhibitors; Clathrin / genetics; Codon / genetics; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Male; Molecular Sequence Data; Monomeric Clathrin Assembly Proteins / chemistry; Monomeric Clathrin Assembly Proteins / genetics; Monomeric Clathrin Assembly Proteins / metabolism; Mutagenesis, Insertional; Pedigree; Phosphatidylinositols / metabolism; Prospective Studies; Protein Conformation; Sequence Analysis, RNA; Sex Factors; Xenopus laevis / embryology
TL;DR: A three-nucleotide exonic insertion in phosphatidylinositol-binding clathrin assembly protein (PICALM) that is associated with the development of SAS in Newfoundlands is identified and the role of PICALM in OFT development may aid in future molecular and genetic investigations into other congenital heart defects of various species. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(5), 534–539.

By: Y. Reina-Doreste n, J. Stern* , B. Keene n, S. Tou n, C. Atkins n, T. DeFrancesco n , M. Ames n, T. Hodge n, K. Meurs n 

MeSH headings : Animals; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cardiotonic Agents / therapeutic use; Case-Control Studies; Cat Diseases / drug therapy; Cat Diseases / mortality; Cats; Female; Heart Failure / drug therapy; Heart Failure / mortality; Heart Failure / veterinary; Male; Pyridazines / therapeutic use; Retrospective Studies
TL;DR: The addition of pimobendan to traditional treatment for CHF may provide a substantial clinical benefit in survival time for HCM-affected cats with CHF and possibly HOCM- affected cats withCHF. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Natural History of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog: A Prospective Study

JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(4), 1214–1220.

By: K. Meurs n , J. Stern n , Y. Reina-Doreste n, A. Spier*, S. Koplitz* & R. Baumwart *

author keywords: Boxer; Holter; Striatin; Sudden death; Ventricular premature complex
MeSH headings : Age Factors; Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Case-Control Studies; Death, Sudden / veterinary; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Genotype; Male; Prospective Studies; Ventricular Premature Complexes / physiopathology; Ventricular Premature Complexes / veterinary
TL;DR: Arrhythmogenic right ventricular cardiomyopathy is a disease of middle age and frequently is associated with the striatin deletion, and the prognosis in many affected dogs is good. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(6), 1437–1440.

By: K. Meurs n , J. Stern n , D. Sisson*, M. Kittleson *, S. Cunningham *, M. Ames n, C. Atkins n, T. DeFrancesco n  ...

author keywords: Boxer; Dilated cardiomyopathy; Mutation; Striatin
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / veterinary; Case-Control Studies; Confidence Intervals; DNA / chemistry; DNA / genetics; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Female; Genotype; Male; Membrane Proteins / genetics; Polymerase Chain Reaction / veterinary; Sequence Deletion / genetics
TL;DR: This study demonstrates an association between DCM in the Boxer dog and the striatin mutation, particularly with the homozygous genotype, and suggests that there is at least 1 other cause of DCm in the boxer dog. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Extent of linkage disequilibrium in large-breed dogs: chromosomal and breed variation

MAMMALIAN GENOME, 24(9-10), 409–415.

By: J. Stern n , S. White * & K. Meurs n 

MeSH headings : Animals; Breeding; Chromosomes, Mammalian / genetics; Dogs / genetics; Female; Genetic Markers; Genome-Wide Association Study; Haplotypes; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide
TL;DR: This is the first reported of SNP-based LD for Newfoundland dogs, the first report based on genome-wide SNPs for Rottweilers, and an almost tenfold improvement in marker density over previous genome- wide studies of LD in Golden Retrievers. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Hybrid cutting balloon dilatation for treatment of cor triatriatum sinister in a cat

JOURNAL OF VETERINARY CARDIOLOGY, 15(3), 205–210.

By: J. Stern n , S. Tou n, P. Barker *, K. Hill *, A. Lodge*, K. Mathews n , B. Keene n

author keywords: Sinistrum; Pulmonary venous anomaly; Feline; Congenital heart disease; Dilatation
MeSH headings : Angioplasty, Balloon, Coronary / methods; Angioplasty, Balloon, Coronary / veterinary; Animals; Cat Diseases / diagnosis; Cat Diseases / therapy; Cats; Cor Triatriatum / diagnosis; Cor Triatriatum / therapy; Cor Triatriatum / veterinary; Echocardiography, Transesophageal / veterinary; Female
TL;DR: Based upon the outcome of this case, balloon dilatation appears to be a viable treatment option for cats affected with cor triatriatum sinister. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Identification of PDE5A:E90K: A Polymorphism in the Canine Phosphodiesterase 5A Gene Affecting Basal cGMP Concentrations of Healthy Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(1), 78–83.

By: J. Stern n , Y. Reina-Doreste n, L. Chdid n & K. Meurs n 

author keywords: Individualized medicine; Pharmacogenomics; Pulmonary hypertension; Sildenafil citrate; Single nucleotide polymorphisms
MeSH headings : Amino Acid Sequence; Animals; Cyclic GMP / metabolism; Cyclic Nucleotide Phosphodiesterases, Type 5 / genetics; Cyclic Nucleotide Phosphodiesterases, Type 5 / metabolism; DNA / chemistry; DNA / genetics; Dogs / genetics; Dogs / metabolism; Molecular Sequence Data; Polymerase Chain Reaction / veterinary; Polymorphism, Single Nucleotide / genetics; Sequence Alignment; Sequence Analysis, DNA
TL;DR: A polymorphism exists in the canine PDE5A gene that is associated with variable circulating cGMP concentrations in healthy dogs and warrants investigation in diseases such as pulmonary hypertension. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Untitled

Journal of the American Veterinary Medical Association, 242(7), 926–928.

By: Y. Doreste, J. Stern & S. Lahmers

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Familial subvalvular aortic stenosis in golden retrievers: inheritance and echocardiographic findings

Journal of Small Animal Practice, 53(4), 213–216.

By: J. Stern, K. Meurs, O. Nelson, S. Lahmers & L. Lehmkuhl

Source: NC State University Libraries
Added: August 6, 2018

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