Works (14)
Updated: July 12th, 2023 12:20
2011 journal article
Tributyltin Synergizes with 20-Hydroxyecdysone to Produce Endocrine Toxicity
TOXICOLOGICAL SCIENCES, 123(1), 71–79.
author keywords: chemical mixtures; models; synergy; invertebrate; ecdysteroid; nuclear receptor; retinoid X receptor; ecdysteroid receptor
MeSH headings : Animals; Cells, Cultured; Daphnia; Dose-Response Relationship, Drug; Drug Synergism; Ecdysterone / metabolism; Ecdysterone / toxicity; Female; Gene Expression / drug effects; Molting / drug effects; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Retinoid X Receptors / genetics; Retinoid X Receptors / metabolism; Signal Transduction; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
TL;DR:
Results demonstrate that xenobiotics, such as tributyltin, can interact with RXR to influence gene expression regulated by the heterodimeric partner to RXR.
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Intracellular Conversion of Environmental Nitrate and Nitrite to Nitric Oxide with Resulting Developmental Toxicity to the Crustacean Daphnia magna
PLoS ONE, 5(8), e12453.
Ed(s): X. Pan
MeSH headings : Animals; Animals, Newborn; Daphnia / cytology; Daphnia / drug effects; Daphnia / growth & development; Daphnia / metabolism; Drosophila / cytology; Drosophila / drug effects; Drosophila / metabolism; Ecdysteroids / metabolism; Ecosystem; Endocrine System / drug effects; Endocrine System / metabolism; Environmental Monitoring; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Female; Intracellular Space / drug effects; Intracellular Space / metabolism; Nitrates / metabolism; Nitrates / toxicity; Nitric Oxide / metabolism; Nitrites / metabolism; Nitrites / toxicity; Reproduction / drug effects; Risk
TL;DR:
Results demonstrate that nitrite elicits developmental and reproductive toxicity at environmentally relevant concentrations due likely to its intracellular conversion to nitric oxide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2010 journal article
Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna)
AQUATIC TOXICOLOGY, 101(2), 351–357.
author keywords: Vitellogenin; Water flea; Biomarker; Ecdysteroids; Estrogens; Endocrine disruption
MeSH headings : Animals; Cadmium / toxicity; Daphnia / drug effects; Daphnia / genetics; Daphnia / metabolism; Ecdysteroids / toxicity; Ecdysterone / toxicity; Environmental Pollutants / toxicity; Estrogens / toxicity; Gene Expression / drug effects; Heterocyclic Compounds / toxicity; Polycyclic Compounds / toxicity; RNA, Messenger / metabolism; Vitellogenins / genetics; Vitellogenins / metabolism; Xenobiotics / toxicity
TL;DR:
Results indicate that ecdysteroids are suppressors of vitellogenin gene expression and that viteLLogenin mRNA levels can be elevated or suppressed in daphnids by xenobiotics that elicit antiecdysteroidal or ecdystersoidal activity, respectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
The screening of chemicals for juvenoid-related endocrine activity using the water flea Daphnia magna
AQUATIC TOXICOLOGY, 74(3), 193–204.
author keywords: endocrine disruptors; screening; juvenoids; sex determination
MeSH headings : Animals; Benzhydryl Compounds; Daphnia / drug effects; Daphnia / metabolism; Ecdysteroids / metabolism; Ecdysteroids / pharmacology; Endocrine System / drug effects; Endpoint Determination / methods; Fatty Acids, Unsaturated / pharmacology; Female; Juvenile Hormones / agonists; Juvenile Hormones / antagonists & inhibitors; Juvenile Hormones / metabolism; Male; Methoprene / pharmacology; Pesticides / toxicity; Phenols / toxicity; Phytol / pharmacology; Pyridines / pharmacology; Reproducibility of Results; Sex Differentiation / drug effects; Toxicity Tests / methods; Tretinoin / pharmacology; United States; United States Environmental Protection Agency
TL;DR:
Results demonstrate that an in vivo assay with a crustacean species customarily employed in toxicity testing can be used to effectively screen chemicals for juvenoid-modulating activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1999 journal article
Isostrength comparison of large-strain (fracture) rheological properties of egg white and whey protein gels
JOURNAL OF FOOD SCIENCE, 64(5), 893–898.
author keywords: gels; rheology; texture; egg white; whey proteins
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 chapter
Intracellular regulation of airway mucin secretion.
In Cilia, mucus and mucociliary interactions (pp. 143–151).
Source: NC State University Libraries
Added: August 6, 2018
1996 article
Histamine stimulates secretion of mucin and activates phospholipase C in airway epithelium: evidence for independent pathways.
American Journal of Respiratory and Critical Care Medicine, Vol. 153, p. A539.
Source: NC State University Libraries
Added: August 6, 2018
1996 article
Nitric oxide: A key signaling molecule regulating airway mucin secretion.
Proceedings of the 9th World Congress on Bronchology & World Congress on Bronchoesophagology., Vol. 9, p. S060.
Source: NC State University Libraries
Added: August 6, 2018
1995 article
Endogenously-generated nitric oxide (NO) may be a key signaling molecule in hypersecretion of mucin by guinea pig tracheal epithelial (GPTE) cells in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 151, p. A337.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
HISTAMINE PROVOKES TURNOVER OF INOSITOL PHOSPHOLIPIDS IN GUINEA-PIG AND HUMAN AIRWAY EPITHELIAL-CELLS VIA AN H-1-RECEPTOR G-PROTEIN-DEPENDENT MECHANISM
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 12(4), 416–424.
MeSH headings : Adult; Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Enzyme Activation; GTP-Binding Proteins / physiology; Gene Expression; Guinea Pigs; Humans; Inositol Phosphates / metabolism; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols / metabolism; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases / metabolism; RNA, Messenger / genetics; Receptors, Histamine H1 / physiology; Signal Transduction; Sodium Fluoride / pharmacology; Virulence Factors, Bordetella / pharmacology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1995 journal article
HYPERSECRETION OF MUCIN IN RESPONSE TO INFLAMMATORY MEDIATORS BY GUINEA-PIG TRACHEAL EPITHELIAL-CELLS IN-VITRO IS BLOCKED BY INHIBITION OF NITRIC-OXIDE SYNTHASE
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 13(5), 526–530.
MeSH headings : Animals; Arginine / analogs & derivatives; Arginine / pharmacology; Cells, Cultured; Enzyme Inhibitors / pharmacology; Guinea Pigs; Histamine / pharmacology; Inflammation Mediators / pharmacology; Mucins / metabolism; Nitric Oxide Synthase / antagonists & inhibitors; Platelet Activating Factor / drug effects; Secretory Rate / drug effects; Superoxides / metabolism; Trachea / metabolism; Tumor Necrosis Factor-alpha / pharmacology; omega-N-Methylarginine
TL;DR:
The results suggest that each of these inflammation-associated mediators provokes airway epithelial mucin secretion via a mechanism involving intracellular production of nitric oxide (NO) as a critical signaling molecule.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1994 journal article
Interactions of oxygen radicals with airway epithelium.
Environmental Health Perspectives. Supplements, 102(11), 85–90.
MeSH headings : Animals; Antioxidants / metabolism; Epithelium / drug effects; Epithelium / physiopathology; Humans; Oxidoreductases / metabolism; Reactive Oxygen Species / pharmacology; Respiratory System / drug effects; Respiratory System / physiopathology
TL;DR:
Reactive oxygen species (ROS) have been implicated in the pathogenesis of numerous disease processes and Respiratory epithelium may be intimately involved in defense against, and pathophysiologic changes invoked by, ROS.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1994 article
Platelet activating factor and histamine activate phospholipase C in airway epithelial cells in vitro via a pertussis toxin sensitive G protein.
American Journal of Respiratory and Critical Care Medicine, Vol. 149, p. A985.
Source: NC State University Libraries
Added: August 6, 2018
1994 article
Reactive oxygen species (ROS) activate phospholipase C in guinea pig and human airway epithelial cells in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 149, p. A315.
Source: NC State University Libraries
Added: August 6, 2018
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