Gregory S. Gojanovich

Works (3)

Updated: July 5th, 2023 21:16

2013 journal article

Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris)

Developmental & Comparative Immunology, 41(4), 578–586.

By: G. Gojanovich n, P. Ross n, S. Holmer n, J. Holmes n & P. Hess n 

author keywords: Alleles; Canine; Immunology; Splice variants; Transporter associated with antigen processing
MeSH headings : ATP-Binding Cassette Transporters / genetics; Alleles; Amino Acid Sequence; Animals; Antigen Presentation / genetics; Cell Line; Dogs; Genetic Variation; Histocompatibility Antigens Class I / genetics; Humans; Mice; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic; Protein Isoforms; Wolves / genetics
TL;DR: The promoter and coding regions of the canine TAP1 and TAP2 genes, which encode the homologous subunits forming the TAP heterodimer, are reported, which should prove useful in investigating the association of specific TAP defects or alleles with immunity to intracellular pathogens and cancer in dogs. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

A cell-based MHC stabilization assay for the detection of peptide binding to the canine classical class I molecule, DLA-88

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 150(3-4), 206–212.

By: P. Ross n, J. Holmes n, G. Gojanovich n & P. Hess n 

author keywords: Canine; CD8(+) T lymphocytes; MHC; Peptides/epitopes
MeSH headings : Animals; Biological Assay / methods; Biological Assay / veterinary; CD8-Positive T-Lymphocytes / metabolism; Cell Line, Tumor; Cell Membrane; Dogs / metabolism; Epitopes; Gene Expression Regulation / physiology; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / metabolism; Mice; Protein Binding; Protein Subunits
TL;DR: The potential to use RMA-S cells transfected with canine alleles as a tool for CTL epitope discovery in this species is demonstrated, and the high false positive rate with this analysis ideally requires binding confirmation. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited

TISSUE ANTIGENS, 80(2), 175–183.

By: P. Ross n, A. Buntzman *, B. Vincent *, E. Grover n, G. Gojanovich n, E. Collins *, J. Frelinger*, P. Hess n 

author keywords: breeds; canine; class I genes; major histocompatibility complex; polymorphisms
MeSH headings : Alleles; Amino Acid Sequence; Animals; Breeding; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Dogs / genetics; Dogs / immunology; Gene Frequency; Genetic Loci; Haplotypes; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Homozygote; Models, Molecular; Molecular Sequence Data; Phylogeny; Polymorphism, Genetic; Sequence Alignment
TL;DR: The finding of highly prevalent alleles fulfills an important prerequisite for studying canine CD8+ T-cell responses and represents a significant advance over previous analyses of major histocompatibility complex class I genes. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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